Information content of spatially distributed ground-based measurements for hydrologic-parameter calibration in mixed rain-snow mountain headwaters

Parameters in hydrologic models used in mixed rain-snow regions are often uncertain to calibrate and overfitted on streamflow. To contribute addressing these challenges, we used an algorithm that assesses modeling performances through time (Dynamic Identifiability Analysis) to quantify the information content of spatially distributed ground-based measurements for identifying optimal parameter values in the Precipitation Runoff Modeling System (PRMS) model. Including spatially distributed ground-based measurements in Identifiability Analysis allowed us to unambiguously estimate more parameter values than only using streamflow (seven parameters instead of two out of a pool of thirty-three). Peaks in information gain were obtained when using dew-point temperature to identify precipitation phase-partitioning parameters. Multi-attribute identifiability analysis also yielded optimal parameter values that were temporally less variable than those estimated using streamflow alone. Overall, identifying parameter values using ground-based measurements improved the simulation of key drivers of the surface-water budget, such as air temperature and precipitation-phase partitioning. However, parameters simulating surface-to-subsurface mass fluxes like snow accumulation and melt or evapotranspiration were poorly identified by any attribute and so emerged as key sources of predictive uncertainty for this distributed-parameter hydrologic model. This work demonstrates the value of expanded ground-based measurements for identifying parameters in distributed-parameter hydrologic models and so diagnosing their conceptual uncertainty across the water budget

Qualidade do solo em áreas de plantio convencional sob latossolos do cerrado.

O cultivo convencional envolve o revolvimento e pulverização do solo, aplicação de corretivos e fertilizantes e exposição das partículas de solo. Este cultivo pode alterar a estrutura do solo, o que reflete no índice de qualidade do solo. Assim, o objetivo do presente estudo foi estabelecer índices que expressam a qualidade do solo em áreas de manejo com cultivo convencional em Latossolos sob Cerrado, através da avaliação de atributos físicos e químicos dos solos

Gamma-hydroxybutyrate (GHB) for prevention and treatment of alcohol withdrawal

This is the protocol for a review and there is no abstract. The objectives are as follows: To evaluate the efficacy and safety of GHB in prevention and treatment of the AWS, more specifically • to compare the efficacy of GHB with placebo or other drugs; • to identify the most effective GHB dosage and schedules; • to estimate the incidence of side effects; • to carry out a risk-benefit analysis

The QARMAv2 Family of Tweakable Block Ciphers

We introduce the QARMAv2 family of tweakable block ciphers. It is a redesign of QARMA (from FSE 2017) to improve its security bounds and allow for longer tweaks, while keeping similar latency and area. The wider tweak input caters to both specific use cases and the design of modes of operation with higher security bounds. This is achieved through new key and tweak schedules, revised S-Box and linear layer choices, and a more comprehensive security analysis. QARMAv2 offers competitive latency and area in fully unrolled hardware implementations. Some of our results may be of independent interest. These include: new MILP models of certain classes of diffusion matrices; the comparative analysis of a full reflection cipher against an iterative half-cipher; our boomerang attack framework; and an improved approach to doubling the width of a block cipher

Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System.

Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical outcomes have been associated with decreased expansion and persistence of adoptively transferred CAR T cells, antigen-negative relapses, and impairment by an immunosuppressive tumor microenvironment. Improvements in CAR T cell design are required to enhance clinical efficacy, as well as broaden the applicability of this technology. Here, we demonstrate that interleukin-18 (IL-18)-secreting CAR T cells exhibit enhanced in vivo expansion and persistence and significantly increase long-term survival in syngeneic mouse models of both hematological and solid malignancies. In addition, we demonstrate that IL-18-secreting CAR T cells are capable of modulating the tumor microenvironment, as well as enhancing an effective endogenous anti-tumor immune response. IL-18-secreting CAR T cells represent a promising strategy to enhance the clinical outcomes of adoptive T cell therapy

relation between ribosomal rna genes and the dna satellites of phaseolus coccineus

The main band DNA of Phaseolus coccineus has a buoyant density of 1.692 g/ml. In roots, shoots, integuments and suspensors there is a DNA satellite with a buoyant density of 1.700 g/ml. The satellite of the roots, shoots and integuments represents approximately 28.2 %, 29.4 % and 34.7 % respectively of the total DNA. In suspensors, where polyteny occurs, besides the 1.700 g/ml satellite there is a second one at 1.696 g/ml. They represent about 32.9 % and 13.1 % of the total DNA. H3-25S and H3-18S ribosomal RNA of Phaseolus coccineus were hybridized separately with DNA of shoots from CsCl gradient fractions. In both hybridizations the peak of labelling coincides with the position of the DNA satellite with a buoyant density of 1.700 g/ml. Thus the genes for 25S and 18S are mainly located in this DNA component. Hybridization experiments at saturation inputs of H3-25S ribosomal RNA with DNA of shoots, integuments, roots and suspensors give saturation values of 0.72 %, 0.64 %, 0.51 % and 0.42 % respectively. The lower saturation value in the suspensors may indicate an underreplication of ribosomal genes in this tissue. This is partly cancelled out by the amplification in another DNA: that of the second satellite at 1.696 g/ml which does not seem to be part of the ribosomal DNA

Pushing Time-Domain Diffuse Optics to Its Ultimate Limits: New Large-Area Detector and Operation Modality

Large area single-photon detectors enhance light harvesting capability beyond state-ofthe-art provided that pile-up distortion is corrected. We test a 10 × 10 mm2 SiPM-based detector and study the possibility to work beyond singe-photon statistics