A lower global lung ultrasound score is associated with higher likelihood of successful extubation in invasively ventilated COVID-19 patients

Lung ultrasound (LUS) can be used to assess loss of aeration, which is associated with outcome in patients with coronavirus disease 2019 (COVID-19) presenting to the emergency department. We hypothesized that LUS scores are associated with outcome in critically ill COVID-19 patients receiving invasive ventilation. This retrospective international multicenter study evaluated patients with COVID-19-related acute respiratory distress syndrome (ARDS) with at least one LUS study within 5 days after invasive mechanical ventilation initiation. The global LUS score was calculated by summing the 12 regional scores (range 0-36). Pleural line abnormalities and subpleural consolidations were also scored. The outcomes were successful liberation from the ventilator and intensive care mortality within 28 days, analyzed with multistate, competing risk proportional hazard models. One hundred thirty-seven patients with COVID-19-related ARDS were included in our study. The global LUS score was associated with successful liberation from mechanical ventilation (hazard ratio [HR]: 0.91 95% confidence interval [CI] 0.87-0.96; P = 0.0007) independently of the ARDS severity, but not with 28 days mortality (HR: 1.03; 95% CI 0.97-1.08; P = 0.36). Subpleural consolidation and pleural line abnormalities did not add to the prognostic value of the global LUS score. Examinations within 24 hours of intubation showed no prognostic value. To conclude, a lower global LUS score 24 hours after invasive ventilation initiation is associated with increased probability of liberation from the mechanical ventilator COVID-19 ARDS patients, independently of the ARDS severity.Pathogenesis and treatment of chronic pulmonary disease

Etude expérimentale d'assemblages squelette-Argile. Apport à la compréhension du comportement physique des sols

* INRA, Centre de Recherche d'Orléans, URD, Ardon 45160 Olivet (FRA) Diffusion du document : INRA, Centre de Recherche d'Orléans, URD, Ardon 45160 Olivet (FRA) Diplôme : Dr. d'Universit

Biology and ecology of the accidentally introduced bleak, Alburnus alburnus (Actinopterygii: Cypriniformes: Cyprinidae), in Keddara Dam Lake, Algeria

Background. In this study, we present the results concerning the growth, reproduction, and trophic activities of bleak, Alburnus alburnus (Linnaeus, 1758), a cyprinid fish recently introduced to Algeria. We need to show that this species is adapted to local conditions. We have also characterized the biological activity of the bleak and the impact of environmental parameters on this activity. Materials and methods. The fish sampling was carried out monthly from May 2008 through February 2012 in Keddara Dam Lake, from a single sampling station located in the proximity of the dam. We studied the biometric parameters of the fish, their length–weight relation, growth parameters, the reproductive and trophic activities, as well as the physical and chemical properties of the water.  The data collected were processed and interpreted using selected biological indices. The climatic data were obtained from the Algerian National Office of Meteorology. The statistical analysis was performed using the R program. Results. The length–weight relation of bleak represented positive allometry. The females grew less rapidly than males between 2–3 years of age. Beyond this age, females grew faster. The condition factor of females and males indicated that environmental conditions were unstable and varied between poor and good. The sex ratio was in favour of females. The reproduction activity was relatively spread over time. During the year there were many phases of sexual maturation and several spawning periods (3–4), which started from the end of January and lasted until the end of July. The last late spawning was between November and December. The sexual rest period was observed between August and September. The hepatosomatic index, in both sexes, showed no great differences. Also, the viscerosomatic index was stable. However, the repletion index was steadily increasing throughout the year. The RDA analysis  analysis allows characterizing the biological activity of the bleak and the impact of environmental parameters. Conclusion. We have characterized the biological and ecological variability of Alburnus alburnus in its new biotope and the relation of this species to the environmental parameters. This study brings new evidence for the adaptive potential of exotic species introduced in North Africa

Slow-release clomipramine acute poisoning with radio-opaque gastric bezoar

SCOPUS: no.jinfo:eu-repo/semantics/publishe

Experimental studies and computational exploration on the 2-amino-5-(2-methoxyphenyl)-1,3,4-thiadiazole as novel corrosion inhibitor for mild steel in acidic environment

International audienceIn the present research, a new 1,3,4-thiadiazole derivative, namely the 2-amino-5-(2-methoxyphenyl)-1,3,4-thiadiazole (5-AMT) was synthesized and investigated as corrosion inhibitor for mild steel (M-steel) in molar hydrochloric acid medium. The experimental studies such as weight loss, potentiodynamic polarization (PDP), Linear polarization resistance (LPR) technique and electrochemical impedance spectroscopy (EIS) were performed in order to evaluate the corrosion protection performance of the tested compound. Based on the experimental outcomes, a protection degree of approximately 98 % was achieved exploiting 5 × 10−4 M of 5-AMT after 1 h of immersion at temperature 303 K. Additionally, PDP study highlighted that the investigated 1,3,4-thiadiazole is of mixed-kind inhibitor. Thermodynamic data from adsorption isotherms and activation energies were determined and discussed. It was shown that the adsorption of 5-AMT molecules fits Langmuir isotherm model. Furthermore, in order to characterize the M-steel surface and to comprehend the adsorption mechanism of 5-AMT, XPS analyses were accomplished. Computational studies by DFT and MD simulation were also conducted to correlate the protection properties and quantum chemical parameters of the investigated inhibitor