Remarks on the emerging regulation methods of emerging nanotechnologies

Regulation of emerging issues needs new forms of governance. This new governance includes soft law approach, dialogues, public engagement, frames of research set by firms and ethics in forms of codes of conduct among other things and, in interaction with the recent dynamics of nanotechnologies, it integrates into a `governance landscape´. This article first summarises and assesses the forms of and reasons for the turn to governance at different issues. Then it interprets both the frame jointly set by DuPont and EDF as well as the NanoCode recommendation worked out by the EC. Reflecting on some views that identify this recent development in the emerging regulation of nanotechnologies as a step in direction toward innovation governance in this field it expresses both the endorsement of this view and some doubts that may invite to paint a bit more differentiated picture of the recent dynamic. ``The regulatory challenge is´´ (...) ``to ensure that society can benefit from novel applications of nanotechnology, whilst a high level of protection of health, safety and the environment is maintained.´´ (Commission 2008, P. 4

FEBS Open Bio seeks an Editor-in-Chief

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Protein-peptide based assay for the characterization of human blood coagulation factor XIII-A isopeptidase activity

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The Effect of Pharmacist-Led Intervention on Surgical Antibacterial Prophylaxis (SAP) at an Orthopedic Unit

Perioperative antibiotic use is a common reason for antibiotic misuse. Evidence suggests that adherence to SAP guidelines may improve outcomes. The purpose of this study was to analyze the impact of pharmacist-led antibiotic stewardship interventions on SAP guideline compliance. The study was conducted at an Orthopedic Department of a tertiary care medical center. SAP compliance and antibiotic exposure in the pre-intervention and intervention period was compared using chi-square, Fisher exact, and Mann-Whitney tests, as appropriate. Prophylactic antibiotic use in orthopedic joint arthroplasties (overall guideline adherence: agent, dose, frequency, duration), clinical outcomes (length of stay-LOS, number of surgical site infections-SSIs), antibiotic exposure and direct antibiotic costs were compared between pre-intervention and intervention periods. Significant improvement in mean SAP duration (by 42.9%, 4.08 +/- 2.08 vs. 2.08 +/- 1.90 days, p < 0.001), and overall guideline adherence regarding antibiotic use (by 56.2%, from 2% to 58.2%, p < 0.001) were observed. A significant decrease was observed in antibiotic exposure in SAP (by 41%, from 6.07 +/- 0.05 to 3.58 +/- 4.33 DDD/patient, p < 0.001), average prophylactic antibiotic cost (by 54.8%, 9278.79 +/- 6094.29 vs. 3598.16 +/- 3354.55 HUF/patient), and mean LOS (by 37.2%, from 11.22 +/- 6.96 to 7.62 +/- 3.02 days, p < 0.001); and a slight decrease in the number of confirmed SSIs was found between the two periods (by 1.8%, from 3% to 1.2%, p = 0.21). Continuous presence of the clinical pharmacist led to significant improvement in SAP guideline adherence, which was accompanied by decreased antibiotic exposure and cost

An involucrin-like protein in hepatocytes serves as a substrate for tissue transglutaminase during apoptosis

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90 éves a Magyar Tudományos Akadémia Ökológiai Kutatóközpont Balatoni Limnológiai Intézete

The Lake Balaton Institute of Limnology of the Ecological Research Centre of the Hungarian Academy of Arts and Sciences is 90 years old. The Balaton Limnology Institute of the Hungarian Academy of Arts and Sciences celebrated the 90th anniversary of its opening on the 8th of September, 2017, in Tihany, where László Fésüs, chairman of the Biology Section of the Hungarian Academy of Sciences greeted the event with the address printed here. The institute, originally called "The Hungarian Biology Research Institute" was the very first independent research institution in Hungary, established and opened in 1927 by the famous politician Kúnó Klébelsberg who is also highly respected for developing university campuses and many new elementary schools. During nine decades the institute attracted leading life scientists from Hungary as well as abroad, its research areas covered the major trends in biology including broad topics in botany, zoology, molecular biology, neurobiology and has had a crucial role saving Lake Balaton from ecological catastrophes