Feedback-Based Channel Frequency Optimization in Superchannels

Superchannels leverage the flexibility of elastic optical networks and pave the way to higher capacity channels in space division multiplexing (SDM) networks. A superchannel consists of subchannels to which continuous spectral grid slots are assigned. To guarantee superchannel operation, we need to account for soft failures, e.g., laser drifts causing interference between subchannels, wavelength-dependent performance variations, and filter misalignments affecting the edge subchannels. This is achieved by reserving spectral guardband between subchannels or by employing a lower modulation format. We propose a process that dynamically retunes the subchannel transmitter (TX) lasers to compensate for soft failures during operation and optimizes the total capacity or the minimum subchannel quality of transmission (QoT) performance. We use an iterative stochastic subgradient method that at each iteration probes the network and leverages monitoring information, particularly subchannels signal-to-noise ratio (SNR) values, to optimize the TX frequencies. Our results indicate that our proposed method always approaches the optima found with an exhaustive search technique, unsuitable for operating networks, irrespective of the subchannel number, modulation format, roll-off factor, filters bandwidth, and starting frequencies. Considering a four-subchannel superchannel, the proposed method achieves 2.47 dB and 3.73 dB improvements for a typical soft failure of +/- 2 GHz subchannel frequency drifts around the optimum, for the two examined objectives

Recent Trends and Considerations for High Speed Data in Chips and System Interconnects

This paper discusses key issues related to the design of large processing volume chip architectures and high speed system interconnects. Design methodologies and techniques are discussed, where recent trends and considerations are highlighted

Taburan, kepelbagaian dan sepsis kelawar di tiga kawasan habitat vegetasi di hutan Sukau, Sandakan , Sabah

This research was carried out with the aim to record and compare information on the diversity, distribution and abundance of bat species at three different habitats of Sukau Rainforest. These were the primary forest, oil palm plantation and village area. Sampling was conducted for six days at each habitat using three mist net and a sweep net. A total of248 individuals of 15 species were caught in this study. Results showed that the village area has the highest bat diversity (H'=1.9) followed by primary forest (H'=I.4). The oil palm plantation area recorded the lowest diversity (H'=O.9). The presence of Sungai Kinabatangan nearby, the close proximity of Gua Keruak, the presence of human settlements and the mixed vegetation were identified to contribute to the high diversity at the village area. It was expected that the primary forest area has higher bat diversity as compared to the oil palm plantation area due to the abundance of food available for bats at this forest and the presence of undisturbed roosting sites. In contrast, the lower diversity recorded at the oil palm plantation was probably because of the less abundance of food available for bats particularly nocturnal insects which is the main diet of Microchiropterans. However, the occurrence of Megachiropterans was high at the oil palm plantation area which is probably because of the presence of oil palm fruits. It can be concluded from this study that there is a difference in terms of bat diversity and this maybe correlated with variation of the vegetations whereby suitability and availability of food and roosting sites play an important role

The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (>= 60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P = 0.0025), shorter leukemia-free survival (P = 0.026) and higher cumulative incidence of relapse (P = 0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P = 0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML

Experimental demonstration of advanced service management in SDN/NFV Fronthaul Networks deploying ARoF and PoF

We demonstrate two advanced services deployed in a novel SDN/NFV optical fronthaul network combining analog radio over fiber (ARoF) and power over fiber (PoF); vertical service management for virtual content delivery networks (vCDNs), and user mobility and remote optical power management for femto cells

The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature

Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their role in acute myeloid leukemia (AML) is mostly unknown.We have examined the expression of the lncRNA HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) in 241 AML patients. We have correlated HOTAIRM1 expression with a miRNA expression profile. We have also analyzed the prognostic value of HOTAIRM1 expression in 215 intermediate-risk AML (IR-AML) patients.The lowest expression level was observed in acute promyelocytic leukemia (P < 0.001) and the highest in t(6;9) AML (P = 0.005). In 215 IR-AML patients, high HOTAIRM1 expression was independently associated with shorter overall survival (OR:2.04;P = 0.001), shorter leukemia-free survival (OR:2.56; P < 0.001) and a higher cumulative incidence of relapse (OR:1.67; P = 0.046). Moreover, HOTAIRM1 maintained its independent prognostic value within the favorable molecular subgroup (OR: 3.43; P = 0.009). Interestingly, HOTAIRM1 was overexpressed in NPM1-mutated AML (P < 0.001) and within this group retained its prognostic value (OR: 2.21; P = 0.01). Moreover, HOTAIRM1 expression was associated with a specific 33-microRNA signature that included miR-196b (P < 0.001). miR-196b is located in the HOX genomic region and has previously been reported to have an independent prognostic value in AML. miR-196b and HOTAIRM1 in combination as a prognostic factor can classify patients as high-, intermediate-, or low-risk (5-year OS: 24% vs 42% vs 70%; P = 0.004).Determination of HOTAIRM1 level at diagnosis provided relevant prognostic information in IR-AML and allowed refinement of risk stratification based on common molecular markers. The prognostic information provided by HOTAIRM1 was strengthened when combined with miR-196b expression. Furthermore, HOTAIRM1 correlated with a 33-miRNA signature

Electron capture at relativistic energies

Available from British Library Document Supply Centre- DSC:D72468/87 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Algebraic methods for finite linear cellular automata

SIGLEAvailable from British Library Document Supply Centre-DSC:DXN010811 / BLDSC - British Library Document Supply CentreGBUnited Kingdo