RECENT ADVANCES IN THE APPLICATION OF HIGH DOSES OF ATORVASTATIN IN PATIENTS WITH CORONARY HEART DISEASE

The results of the recently completed clinical studies on the efficacy of atorvastatin in high doses are presented. In these studies high dose atorvastatin therapy was used in patients with acute coronary syndrome, chronic coronary heart disease, and percutaneous coronary interventions. Studies completed in Russia and devoted to efficacy of the high dose atorvastatin therapy are discussed specially

Prospects of controlling the propagation of high power THz radiation by passive optical elements including 3D printed

Different types of optical elements for controlling high power THz radiation were studied. Controlling was performed utilizing amplitude modulation of the electric field and effective spatial modulation of the complex dielectric susceptibility in the volume of the THz filter. We make a comparison of attenuation efficiency of various options of 3D printed filters when ABS filament is mixed with perovskite microparticles. Another type of filter was obtained by the deposition of magnetic particles in the presence of an external magnetic field in a transparent polymer matrix. Industrial isotropic cut-off filters based on layered meta structures have also been investigated. A comparison is made of the efficiency of attenuation of linearly polarized THz radiation with homemade band-pass polarizers obtained by etching copper from a flexible polyimide substrate and industrial filters. Filters and polarizers created using 3D printing, or by deposition of polymer matrix with magnetic particles under external field, are attractive cost effective elements

Development of electrochemical sensor based on aptamer specific to lung cancer tumor marker

Electrochemical aptasensor is a sensor based on an indicator electrode covered with a layer of an aptamer that is able to bind target molecules with high specificity. In this work, DNA-aptamer LC-2108 specific to lung cancer tumor marker was immobilized onto the surface of golden screen-printed and disc electrodes. The electrodes were studied by conventional electrochemical methods–cyclic voltammetry and electrochemical impedance spectroscopy. The current increase and electron transfer resistance decrease were registered. It seems as if the aptamer presence facilitated the electron transfer through the electrode-solution boundary. As the possible reasons of such an unusual electrochemical behavior we proposed the unordinary or irregular structure of the aptamer layer on the Au surface or the specific electrochemical properties of the aptamer itself

Political Assessment of the October Revolution of 1917 as an Initial Stage in the Formation of the Personality Cult of Stalin in the Era of Proletarian Dictatorship

The question of the starting point of the ascent of I.V. Stalin to unified authority is still the key in the historiography of the October Revolution of 1917, which had a great influence on the formation of I.V. Stalin as a politician. The revolution has fostered in him a sense of purpose, a will to win, a desire not to overturn a political opponent. His role in the uprising is very modest. But from the speech to the speech on the pages of the Soviet mass media, Stalin more and more clearly emphasized his closeness to the leader of the revolution — V.I. Lenin, which was important for creating the image of one of the leaders of the armed uprising. Thus, the ascent to individual power began even before 1921, when Stalin became Secretary-General of the RCP (B)

Application of Risk Assessment Methodology for Substantiation of Measures Complex on Provision of Safe Functioning of Mobile Laboratories of Specialized Anti-Epidemic Teams

A set of risk assessment methods was used for substantiation of safe functioning of mobile laboratories (ML) of specialized anti-epidemic teams (SAET). The utilized methods were borrowed from diverse spheres of activity and recommended for evaluation of biological hazard and risk associated with work with pathogenic biological agents. The obtained data represent the basis for biorisk management in SAET` ML functioning