Clustering of i-dropout galaxies at z=6 in GOODS and the UDF

We measured the angular clustering at z~6 from a large sample of i-dropout galaxies (293 with z<27.5 from GOODS and 95 with z<29.0 from the UDF). Our largest and most complete subsample (having L>0.5L*) shows the presence of clustering at 94% significance. For this sample we derive a (co-moving) correlation length of r_0=4.5^{+2.1}_{-3.2} h_{72}^{-1} Mpc and bias b=4.1^{+1.5}_{-2.6}, using an accurate model for the redshift distribution. No clustering could be detected in the much deeper but significantly smaller UDF, yielding b<4.4 (1 sigma). We compare our findings to Lyman break galaxies at z=3-5 at a fixed luminosity. Our best estimate of the bias parameter implies that i-dropouts are hosted by dark matter halos having masses of ~10^11 M_sun, similar to that of V-dropouts at z~5. We evaluate a recent claim that at z>5 star formation might have occurred more efficiently compared to that at z=3-4. This may provide an explanation for the very mild evolution observed in the UV luminosity density between z=6 and z=3. Although our results are consistent with such a scenario, the errors are too large to find conclusive evidence for this.Comment: minor changes to match published versio

Optical to mid-IR observations of Lyman-alpha galaxies at redshift 5 in the HUDF: a young and low mass population

High redshift galaxies selected on the basis of their strong Lyman-alpha emission tend to be young ages and small physical sizes. We show this by analyzing the spectral energy distribution (SED) of 9 Lyman-alpha emitting (LAE) galaxies at 4.0 < z < 5.7 n the Hubble Ultra Deep Field (HUDF). Rest-frame UV to optical 700A < lambda < 7500A luminosities, or upper limits, are used to constrain old stellar populations. We derive best fit, as well as maximally massive and maximally old, properties of all 9 objects. We show that these faint and distant objects are all very young, being most likely only a few millions years old, and not massive, the mass in stars being ~10^6-10^8 M_sun. Deep Spitzer Infrared Array Camera (IRAC) observations of these objects, even in cases where objects were not detected, were crucial in constraining the masses of these objects. The space density of these objects, ~1.25x10^-4 Mpc^-3 is comparable to previously reported space density of LAEs at moderate to high redshifts. These Lyman-alpha galaxies show modest star formation rates of ~8 M_sun yr^-1, which is nevertheless strong enough to have allowed these galaxies to assemble their stellar mass in less than a few x10^6 years. These sources appear to have small physical sizes, usually smaller than 1 Kpc, and are also rather concentrated. They are likely to be some of the least massive and youngest high redshift galaxies observed to date.Comment: 27 pages. Accepted. To appear in The Astrophysical Journa

On the autonomous detection of coronal mass ejections in heliospheric imager data

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95523/1/jgra21843.pd

Vitamin D in the general population of young adults with autism in the Faroe Islands

Vitamin D deficiency has been proposed as a possible risk factor for developing autism spectrum disorder (ASD). 25-Hydroxyvitamin D3 (25(OH)D3) levels were examined in a cross-sectional population-based study in the Faroe Islands. The case group consisting of a total population cohort of 40 individuals with ASD (aged 15–24 years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and their 77 parents, and also significantly lower than 40 healthy age and gender matched comparisons. There was a trend for males having lower 25(OH)D3 than females. Effects of age, month/season of birth, IQ, various subcategories of ASD and Autism Diagnostic Observation Schedule score were also investigated, however, no association was found. The very low 25(OH)D3 in the ASD group suggests some underlying pathogenic mechanism

BBC2 and world cinema

© Edinburgh University Press. This article examines the origins of BBC2's reputation as a purveyor of films from around the world, exploring the significance and impact of the strand World Cinema (1965-74) and assessing the range and diversity of its offer. Foreign-language titles had been broadcast by the Corporation since before the Second World War, due partly to their ready availability at a time when Hollywood films were 'off limits', given the hostility of American (and British) film companies towards the new rival medium of television. During this early period, however, these continental films were not popular, undoubtedly due to the fact that subtitles were very difficult to read on small, low-definition television screens. BBC2, with its commitment to minority tastes and interests and its use of both the higher-definition 625-line UHF system and colour, was perfectly placed to revive and foster interest in world cinema. For those who urged broadcasters to adopt and maintain an enlightened film policy, World Cinema became exemplary, as a rare exception to the general rules in early television of editing for content or length, block buying (the practice of buying the rights to a mixed package of films in order to acquire certain gems) and haphazard scheduling. For a generation of cinephiles, World Cinema was a formative and educative experience. Particular attention is paid here to the first five years of World Cinema, which saw the strand give attention to a variety of 'New Waves' and relay experiences from behind the Iron Curtain and further afield

Attentional Processing in C57BL/6J Mice Exposed to Developmental Vitamin D Deficiency

Epidemiological evidence suggests that Developmental Vitamin D (DVD) deficiency is associated with an increased risk of schizophrenia. DVD deficiency in mice is associated with altered behaviour, however there has been no detailed investigation of cognitive behaviours in DVD-deficient mice. The aim of this study was to determine the effect of DVD deficiency on a range of cognitive tasks assessing attentional processing in C57BL/6J mice. DVD deficiency was established by feeding female C57BL/6J mice a vitamin D-deficient diet from four weeks of age. After six weeks on the diet, vitamin D-deficient and control females were mated with vitamin D-normal males and upon birth of the pups, all dams were returned to a diet containing vitamin D. The adult offspring were tested on a range of cognitive behavioural tests, including the five-choice serial reaction task (5C-SRT) and five-choice continuous performance test (5C-CPT), as well as latent inhibition using a fear conditioning paradigm. DVD deficiency was not associated with altered attentional performance on the 5C-SRT. In the 5C-CPT DVD-deficient male mice exhibited an impairment in inhibiting repetitive responses by making more perseverative responses, with no changes in premature or false alarm responding. DVD deficiency did not affect the acquisition or retention of cued fear conditioning, nor did it affect the expression of latent inhibition using a fear conditioning paradigm. DVD-deficient mice exhibited no major impairments in any of the cognitive domains tested. However, impairments in perseverative responding in DVD-deficient mice may indicate that these animals have specific alterations in systems governing compulsive or reward-seeking behaviour

Mycobacterium tuberculosis pks12 Produces a Novel Polyketide Presented by CD1c to T Cells

CD1c-mediated T cells are activated by a mycobacterial phospholipid antigen whose carbohydrate structure precisely corresponds to mammalian mannosyl β-1-phosphodolichol (MPD), but contains an unusual lipid moiety. Here, we show that this T cell antigen is a member of a family of branched, alkane lipids that vary in length (C30-34) and are produced by medically important mycobacteria such as M. tuberculosis and M. bovis Bacille-Calmette-Guerin. The alkane moiety distinguished these mycobacterial lipid antigens from mammalian MPDs and was necessary for activation of CD1c-restricted T cells, but could not be accounted for by any known lipid biosynthetic pathway. Metabolic labeling and mass spectrometric analyses suggested a mechanism for elongating lipids using alternating C2 and C3 units, rather than C5 isopentenyl pyrophosphate. Inspection of the M. tuberculosis genome identified one candidate gene, pks12, which was predicted to encode the largest protein in M. tuberculosis, consisting of 12 catalytic domains that correspond to key steps in the proposed pathway. Genetic deletion and complementation showed that Pks12 was necessary for antigen production, but did not affect synthesis of true isoprenols. These studies establish the genetic and enzymatic basis for a previously unknown type of polyketide, designated mycoketide, which contains a lipidic pathogen-associated molecular pattern