Association of State Legislation of Human Papillomavirus Vaccination with Vaccine Uptake Among Adolescents in the United States

We assessed the association of state legislation with adolescent human papillomavirus (HPV) vaccination rates in states that legislated information dissemination or administration of HPV vaccination. Using insurance claims, we calculated monthly HPV vaccination rates (November 2009–December 2017) among adolescents in states that passed HPV vaccination legislation during that period: Missouri (July 2010), Kentucky (February 2012), Indiana (March 2013), Oregon (June 2013). We used segmented regression to estimate levels and trends of HPV vaccination rates, comparing pre-legislation to post-legislation segments, adjusting for seasonal vaccination patterns and changes to the vaccination recommendation among males during the study period. Indiana’s legislation allowed pharmacists to administer HPV vaccination; legislation in Kentucky, Missouri, and Oregon included provisions HPV and cervical cancer education. No statistically significant increases in HPV vaccination levels or trends were observed in the post-legislation segments among adolescents overall; however, a significant post-legislation increase in vaccination trends was observed among boys in Missouri (β = 0.16, p = 0.03). Evidence for a positive impact of legislation on HPV vaccination rates is limited. The scarcity of policies that directly facilitate or promote HPV vaccination, and the breadth of exemptions to school vaccination requirements, may limit the effectiveness of these policies. Continuing efforts to introduce and pass legislation that directly facilitates HPV vaccination, combined with promoting existing evidence-based interventions, can provide opportunities to identify the most effective strategies to increase adolescent HPV vaccination rates

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors

Hydrotransport plugging study. FY 1980-1981 progress report

Large-particle hydrotransport flow phenomena are analyzed. These include particle suspension mechanisms, relative in situ slip between phases, and shear between separated solid/liquid flow regions. These phenomena are related to the mechanistic force balance modeling approach to predicting nominal and minimum horizontal pipeline transport conditions. Results of four series of tests in a 35 m-long, 0.165 m-diameter plexiglass pipeline are presented. These tests were designed to investigate isolated flow phenomena related to lower limits of operation of large-particle transport. They included measurements of the particle size dependence and flow geometry dependence on interfacial friction factors, initiation of plug flow motion, and plugging tendencies of flow through upward-turning elbows. Numerous flow phenomena and parameter dependencies are included in analysis of predictions made using the force balance modeling approach. Comparisons with data are made where possible and a step-by-step solution procedure is presented. Results show agreement with some data sets and disagreement with others. Most available data, however, are neither extensive enough nor accurate enough to form complete conclusions as to the minimum operating conditions predicted with the force balance modeling approach. Additional data from a systematic experimental program in a once-through pipeline system are necessary to further verify the modeling approach. Amore » limited qualitative analysis of methods proposed to unplug large particle pipelines is presented. Methods assessed include pulsed air injection, vibration augmentation, friction reducing surfactant injection, and mechanical or hydraulic boring machinery. Advantages and disadvantages of each method are assessed qualitatively. Laboratory and field testing are required to determine applications.« l

Hydrotransport plugging study. FY 1980-1981 progress report

Large-particle hydrotransport flow phenomena are analyzed. These include particle suspension mechanisms, relative in situ slip between phases, and shear between separated solid/liquid flow regions. These phenomena are related to the mechanistic force balance modeling approach to predicting nominal and minimum horizontal pipeline transport conditions. Results of four series of tests in a 35 m-long, 0.165 m-diameter plexiglass pipeline are presented. These tests were designed to investigate isolated flow phenomena related to lower limits of operation of large-particle transport. They included measurements of the particle size dependence and flow geometry dependence on interfacial friction factors, initiation of plug flow motion, and plugging tendencies of flow through upward-turning elbows. Numerous flow phenomena and parameter dependencies are included in analysis of predictions made using the force balance modeling approach. Comparisons with data are made where possible and a step-by-step solution procedure is presented. Results show agreement with some data sets and disagreement with others. Most available data, however, are neither extensive enough nor accurate enough to form complete conclusions as to the minimum operating conditions predicted with the force balance modeling approach. Additional data from a systematic experimental program in a once-through pipeline system are necessary to further verify the modeling approach. A limited qualitative analysis of methods proposed to unplug large particle pipelines is presented. Methods assessed include pulsed air injection, vibration augmentation, friction reducing surfactant injection, and mechanical or hydraulic boring machinery. Advantages and disadvantages of each method are assessed qualitatively. Laboratory and field testing are required to determine applications

The founding of a nonprofit organization as a teaching/learning experience: A case study in service learning.

The present case study describes how the founding, by faculty, of a nonprofit organization has aided marketing instructors (and instructors of other disciplines) in teaching students to understand and apply marketing (and other business) theories in a “real-world” environment. To that end, the case study is organized as follows. First, it offers a short discussion on the pros and cons of working with for-profit versus nonprofit organizations to add value to the learning experience for students. Second, it describes the benefits and drawbacks instructors and/or students have experienced from starting their own nonprofit organization as a teaching or learning tool to help translate marketing theory into marketing application

Disability and health status: ethnic differences among women in the United States

STUDY OBJECTIVES—There are few data describing disability and health status for ethnic groups. The disablement process involves social influences, which may include minority status. Cross sectional data were examined to investigate the relation of ethnicity to disability.
DESIGN—A stratified random digit dialled sample of women aged 40 and older. Disability and health status were measured as functional and activity limitations, work disability, and days of poor physical and mental health.
SETTING—United States.
PARTICIPANTS—Women interviewed by telephone included 774 white, 749 African-American, 660 Hispanic, and 739 Native American women.
MAIN RESULTS—The prevalence of disability was higher among minority women when classified by general health status, and the need for personal care assistance. There was a striking excess of work disability: 3.5% of white women compared with 7.1% to 10.3% for minority women. The differences were reduced when adjusted for other risk factors and socioeconomic status. White and minority women reported more similar disability when it was defined by poor mental and physical health days.
CONCLUSIONS—Disability is correlated with social and demographic characteristics as well as medical diagnoses. Ethnicity also is associated with disability and may be part of a social context for disablement. Future research should concentrate on the temporal sequence of disability. Consistent definitions of disability will facilitate this research.


Keywords: women's health; health status; disability; minority group

Community Alliances and Participatory Action Research as a mechanism for re-politicising social action for students in Higher Education

Evidence from the UN World Youth Report (2015) suggests that young people, while increasingly disengaged with formal political processes, are motivated by cause-related social action. Higher Education (HE), through research and partnership, provides ideal learning spaces to explore cause-related social action. However, as HE partnership opportunities continue to be reframed under a narrative of employability and one-off participation, there is a risk that these experiences miss an opportunity to critically engage young people with issues at a socio-political level. This research paper considers the potential of participatory action research (PAR) as a pedagogical mechanism for re-politicising social action for students in a UK HE context. The project explores the experiences of 160 undergraduate students, working in partnership with 400 young children, aged 2-10 years, to investigate and co-construct their views and action concerning causes represented by local community organisations. Findings suggest that using participatory, youth-action approaches students shifted their self-identified positions from a non-social orientated approach to establishing them as advocates for causes and children’s voices. We argue that PAR, as a learning experience, and service-learning pedagogy open up an alternative experience of social action through an educational context with engagement and consideration of social issues. In conclusion, we call for new alliances between HE, young people, and community organisations, to produce, through enquiry, critical knowledge aimed at social transformation, which can open-up authentic democratic spaces within the learning communities in HE and its networks