Dosimetric impact of gastrointestinal air column in radiation treatment of pancreatic cancer

OBJECTIVE: Dosimetric evaluation of air column in gastrointestinal (GI) structures in intensity modulated radiation therapy (IMRT) of pancreatic cancer. METHODS: Nine sequential patients were retrospectively chosen for dosimetric analysis of air column in the GI apparatus in pancreatic cancer using cone beam CT (CBCT). The four-dimensional CT (4DCT) was used for target and organs at risk (OARs) and non-coplanar IMRT was used for treatment. Once a week, these patients underwent CBCT for air filling, isocentre verification and dose calculations retrospectively. RESULTS: Abdominal air column variation was as great as ±80% between weekly CBCT and 4DCT. Even with such a large air column in the treatment path for pancreatic cancer, changes in anteroposterior dimension were minimal (2.8%). Using IMRT, variations in air column did not correlate dosimetrically with large changes in target volume. An average dosimetric deviation of mere -3.3% and a maximum of -5.5% was observed. CONCLUSION: CBCT revealed large air column in GI structures; however, its impact is minimal for target coverage. Because of the inherent advantage of segmentation in IMRT, where only a small fraction of a given beam passes through the air column, this technique might have an advantage over 3DCRT in treating upper GI malignancies where the daily air column can have significant impact. Advances in knowledge: Radiation treatment of pancreatic cancer has significant challenges due to positioning, imaging of soft tissues and variability of air column in bowels. The dosimetric impact of variable air column is retrospectively studied using CBCT. Even though, the volume of air column changes by ± 80%, its dosimetric impact in IMRT is minimum

Discrete Symmetries in Covariant LQG

We study time-reversal and parity ---on the physical manifold and in internal space--- in covariant loop gravity. We consider a minor modification of the Holst action which makes it transform coherently under such transformations. The classical theory is not affected but the quantum theory is slightly different. In particular, the simplicity constraints are slightly modified and this restricts orientation flips in a spinfoam to occur only across degenerate regions, thus reducing the sources of potential divergences.Comment: 8 pages, v2: Minor change

Rapid sea level rise in the aftermath of a Neoproterozoic snowball Earth

Earth’s most severe climate changes occurred during global-scale “snowball Earth” glaciations, which profoundly altered the planet’s atmosphere, oceans, and biosphere. Extreme rates of glacioeustatic sea level rise are predicted by the snowball Earth hypothesis, but supporting geologic evidence has been lacking. We use paleohydraulic analysis of wave ripples and tidal laminae in the Elatina Formation, Australia—deposited after the Marinoan glaciation ~635 million years ago—to show that water depths of 9 to 16 meters remained nearly constant for ~100 years throughout 27 meters of sediment accumulation. This accumulation rate was too great to have been accommodated by subsidence and instead indicates an extraordinarily rapid rate of sea level rise (0.2 to 0.27 meters per year). Our results substantiate a fundamental prediction of snowball Earth models of rapid deglaciation during the early transition to a supergreenhouse climate

Reduced dimensionality spin-orbit dynamics of CH3 + HCl reversible arrow CH4 Cl on ab initio surfaces

A reduced dimensionality quantum scattering method is extended to the study of spin-orbit nonadiabatic transitions in the CH3 + HCl reversible arrow CH4 + Cl(P-2(J)) reaction. Three two-dimensional potential energy surfaces are developed by fitting a 29 parameter double-Morse function to CCSD(T)/IB//MP2/cc-pV(T+d)Z-dk ab initio data; interaction between surfaces is described by geometry-dependent spin-orbit coupling functions fit to MCSCF/cc-pV(T+d)Z-dk ab initio data. Spectator modes are treated adiabatically via inclusion of curvilinear projected frequencies. The total scattering wave function is expanded in a vibronic basis set and close-coupled equations are solved via R-matrix propagation. Ground state thermal rate constants for forward and reverse reactions agree well with experiment. Multi-surface reaction probabilities, integral cross sections, and initial-state selected branching ratios all highlight the importance of vibrational energy in mediating nonadiabatic transition. Electronically excited state dynamics are seen to play a small but significant role as consistent with experimental conclusions. (C) 2011 American Institute of Physics. [doi:10.1063/1.3592732

OH species, U ions, and CO/CO2 in thermally annealed metamict zircon (ZrSiO4)

Metamict zircon crystals have been thermally annealed between 500 and 1800 K and analyzed\ud using infrared and optical spectroscopy in the spectral region of 1400–7000 cm–1. Recrystallization\ud and dehydroxylation via complex proton/OH diffusion, redistribution, and incorporations of additional\ud hydrogen-related species within the crystal structure of zircon occur at temperatures above 700 K\ud in partially metamict zircon and above 1200 K in heavily amorphized material. Thermally induced\ud changes in O-H stretching spectra are different between E || c and E ⊥ c in weakly metamict zircon. The\ud O-H stretching band near 3342 cm–1 (with E ⊥ c) in an untreated sample shifts to 3277 cm–1 at 1200 K,\ud where the frequency of O-H stretching bands with E || c increases. Conversions of hydrogen-related\ud species were observed and extra OH bands were found at temperatures between 1200 and 1600 K. A\ud dramatic change of OH spectra was recorded between 1600 and 1800 K in partially metamict crystals,\ud resulting in additional absorption features (near 3098 and 2998 cm–1 along E ⊥ c). U4+ and U5+ related\ud spectra are also affected by high-temperature annealing. For highly metamict zircon, the U4+ band\ud near 4830 cm–1 shows an increase in intensity above 1200 K. Additional IR bands at 2146 and 2344\ud cm–1 appear in the spectra of metamict zircon annealed at high temperatures. Their frequencies are\ud consistent with stretching vibrations of CO and CO2

Nano-porosity in GaSb induced by swift heavy ion irradiation

Nano-porous structures form in GaSb after ion irradiation with 185 MeV Au ions. The porous layer formation is governed by the dominant electronic energy loss at this energy regime. The porous layer morphology differs significantly from that previously reported for low-energy, ion-irradiated GaSb. Prior to the onset of porosity, positron annihilation lifetime spectroscopy indicates the formation of small vacancy clusters in single ion impacts, while transmission electron microscopy reveals fragmentation of the GaSb into nanocrystallites embedded in an amorphous matrix. Following this fragmentation process, macroscopic porosity forms, presumably within the amorphous phase.The authors thank the Australian Research Council for support and the staff at the ANU Heavy Ion Accelerator Facility for their continued technical assistance. R.C.E. acknowledges the support from the Office of Basic Energy Sciences of the U.S. DOE (Grant No. DE-FG02-97ER45656)

Radio Astronomy

Contains report on one research project.National Aeronautics and Space Administration (Grant NGL 22-009-016)National Science Foundation (Grant GP-14854)National Science Foundation (Grant GP-13056

Radio Astronomy

Contains reports on three research projects.National Aeronautics and Space Administration (Grant NGL 22-009-016)National Science Foundation (Grant GP-8415)Joint Services Electronics Programs (U. S. Army, U.S. Navy, and U. S. Air Force) under Contract DA 28-043-AMC-02536(E