The biology and behaviour of a free-living population of black rats (Rattus rattus)

A population of wild Rattus rattus living in the roofs of the laboratory buildings was studied by supplying food every evening and watching the behaviour of the animals at the feeding place. Some observations were also made on caged animals. The rats were predominantly of the black rattus variety but white-bellied greys appeared now and then. In breeding tests the grey colour behaved as though determined by a single recessive gene. The study covered two periods of approximately 9 months each, separated by an interval of 3 months during which a reduced quantity of food was provided and the rat population underwent a major decline. During the two periods of richer feeding the population first increased and then stabilized at a level where the animals remained in good condition and there was no starvation. In the first 9-month period, stabilization was achieved by emigration of young adults who colonized neighbouring buildings. Towards the end of the second period, stabilization was achieved by limitation of breeding. The rats accepted a wide variety of foods, including meat, and a number of instances of predation were seen. Small vertebrates as well as insects were killed and eaten. Small pieces of food were usually eaten in situ but large bits were taken up to the nests in the roof. Such differential treatment in relation to size may be a factor of some importance in the evolution of hoarding. The rats visiting the feeding place formed a unit with a definite social structure. A single dominant male and never more than one, was always present and in certain circumstances a linear male hierarchy was formed. There were usually two or three mutually tolerant top ranking females who were subordinate to the top male but dominant to all other members of the group. Within the group attacks were directed downwards in the social scale. An attacked subordinate either fled or appeased and serious fights therefore did not develop. The most essential component of the appease. ment appeared to be a mouth to mouth contact which may be derived from the infantile pattern of 'mouth suckling'. Appeasement permitted superior rats to maintain their status without the necessity of carrying attacks on subordinates to the point where actual hurt was inflicted. A group territory round the feeding place was defended against interlopers. Both sexes took part in chasing out intruders but since males showed inhibition in attacking females, the exclusion of strange females was due principally to the activities of the home females. The point at which pursuit of an intruder stopped was regarded as the territorial boundary. This was also the limit beyond which a group member would not allow himself to be chased but it was not a prison wall. When agonistic tendencies were not aroused the animals no longer always I turned back at the boundary and foraging beyond its limits allowed them to become familiar with an area larger than the territory. Although intruders were normally driven out, it was occasionally possible for a particularly determined animal of either sex to force its way in and ultimately become a member of the group. The patterns of behaviour seen are described, particularly those concerned with hostile encounters and with mating. Scent marking with urine drip trails was not seen but adults of both sexes marked by rubbing the cheeks and ventral surface on branches. The circumstances in which tooth gnashing was heard suggest that this behaviour is not a form of threat but a response to unfamiliar auditory or visual stimuli. There was some evidence that it functioned as an alarm signal within the group. Pilo-erection and a gait or posture with the hind legs much extended ('stegosauring') are considered to function as threats. Pilo-erection occurred in situations where there was little to suggest conflict and is considered to represent a form of threat which has undergone emancipation. Various forms of displacement and ambivalent behaviour were seen. Rapid vibration of the tail occurred in thwarting situations, either during mating or when a defeated opponent suddenly vanished. There was no evidence that it acted as a signal. The common form of amicable behaviour was social grooming. Another amicable action was sitting together with the bodies in contact. Animals reared in cages remained shy and wary and even hand reared young developed the usual alarm responses to movement and noises. Females had their first litters at ages of 3 to 5 months. For first litters gestation periods were 21 to 22 days but in females that were simultaneously lactating they ranged from 23 to 29 days. Eight was the commonest litter number and ten the highest recorded. At birth the tail is very much shorter than the body but has outstripped it by the time the youngster emerges from the nest. This was found to be the result of a period of extremely rapid tail growth immediately preceding emergence. In Rattus norvegicus the peak in tail growth rate was found to be later and less striking. The difference is interpreted as related to the importance of the tail in climbing in the more arboreal R. rattus. During the second week of life an edge response (retreat from a declivity) and a clinging response made their appearance: these have the function of preventing accidental falls from a nest situated above ground level. Mouth suckling was seen only during a period of a few days towards the end of lactation. Play developed within a few days of emergence from the nest: locomotor and fighting play were the common types. Older animals occasionally joined in play with the young. In problem solving tests, first solutions were not insightful but once a solution had been found, the successful technique was at once adopted and subsequently perfected. There was no evidence of learning by imitation but the rats did learn from each other's behaviour that food could be obtained at a certain location and thus the solution of a problem by one rat accelerated its independent solution by others. The reasons for the differences between the behaviour of the free living population and the caged animals studied by other authors are discussed

Anarchy and conservatism in physiological evolution : inaugural lecture delivered at Rhodes University

Inaugural lecture delivered at Rhodes UniversityRhodes University Libraries (Digitisation

Cardiovascular complications of conventional and targeted adjuvant breast cancer therapy

Adjuvant therapy has improved the survival of women with early breast cancer (BC). Meta-analyses suggest that anthracycline-based regimens reduced the annual BC death rate by ∼40% in women below the age of 50 and 20% in older women. Novel agents designed to modulate abnormal growth factor signaling in and around the BC cell further increase patients' chances of survival. However, both conventional chemotherapeutic agents as well as some of the novel signaling inhibitors can induce important cardiovascular side-effects, potentially attenuating the progress made in recent years. The mechanism of cancer drug-induced cardiovascular complications varies greatly with some compounds inducing irreversible myocardial cell damage, while others lead to temporary cell dysfunction. The challenge of the future will be to prospectively discriminate between irreversible damage which can lead to progressive cardiovascular disease and reversible cardiovascular dysfunctions without further prognostic implications. Since adjuvant therapy for BC is potentially curative, emphasis must be placed on finding treatments combining maximum efficacy with the minimum of long-term side-effects in order to achieve survival with preserved quality of lif

Cancer drugs and the heart: importance and management

Progress in the detection and treatment of cancer has led to an impressive reduction in both mortality and morbidity. Due to their mechanism of action, however, conventional chemotherapeutics and some of the newer anti-cancer signaling inhibitors carry a substantial risk of cardiovascular side effects that include cardiac dysfunction and heart failure, arterial hypertension, vasospastic and thromboembolic ischaemia, dysrhythmia, and QT prolongation. While some of these side effects are irreversible and cause progressive cardiovascular disease, others induce only temporary dysfunction with no apparent long-term sequelae for the patient. The challenge for the cardiovascular specialist is to balance the need for life-saving cancer treatment with the assessment of risk from cancer drug-associated cardiovascular side effects to prevent long-term damage. This review discusses concepts for timely diagnosis, intervention, and surveillance of cancer patients undergoing treatment, and provides approaches to clinical uncertaintie

A collection of Phacochoerus aethiopicus teeth from the Kalkbank middle stone age site, central Transvaal

Main ArticleA Middle Stone Age site at Kalkbank, near Pietersburg in the northern Transvaal, has recently been excavated for the Archaeological Survey by R. Mason: a description of the site and the archaeological findings is shortly to be published (Mason, in press). In addition to the cultural material, animal remains are abundant; the present paper deals with the Suid material which has been found at Kalkbank. This consists of a large collection of teeth, almost all isolated, comprising (apart from much damaged fragments) 53 reasonably complete third, 29 second and 10 first molars, together with 29 upper and 25 lower canines and a single last milk molar. As will be shown later, this material is all referable to the extinct Phacochoerus aethiopicus (Pallas). It constitutes the best collection of material of this species from a single locality that is at present available for study, and therefore adds something to our knowledge of the characteristics of the dentition of this species.The South African Council for Scientific and Industrial Researc

Movement patterns and athletic performance of leopards in the Okavango Delta

Although leopards are the most widespread of all the big cats and are known for their adaptability, they are elusive and little is known in detail about their movement and hunting energetics. We used high-resolution GPS/IMU (inertial measurement unit) collars to record position, activity and the first high-speed movement data on four male leopards in the Okavango Delta, an area with high habitat diversity and habitat fragmentation. Leopards in this study were generally active and conducted more runs during the night, with peaks in activity and number of runs in the morning and evening twilight. Runs were generally short (less than 100 m) and relatively slow (maximum speed 5.3 m s−1, mean of individual medians) compared to other large predators. Average daily travel distance was 11 km and maximum daily travel distance was 29 km. No direct correlation was found between average daily temperature and travel distance or between season and travel distance. Total daily energy requirements based on locomotor cost and basal metabolic rate varied little between individuals and over time. This study provides novel insights into movement patterns and athletic performance of leopards through quantitative high-resolution measurement of the locomotor, energetic, spatial and temporal movement characteristics. The results are unbiased by methodological and observational limitations characteristic of previous studies and demonstrate the utility of applying new technologies to field studies of elusive nocturnal species

Comparative Morphology of the Penis and Clitoris in Four Species of Moles (Talpidae).

The penile and clitoral anatomy of four species of Talpid moles (broad-footed, star-nosed, hairy-tailed, and Japanese shrew moles) were investigated to define penile and clitoral anatomy and to examine the relationship of the clitoral anatomy with the presence or absence of ovotestes. The ovotestis contains ovarian tissue and glandular tissue resembling fetal testicular tissue and can produce androgens. The ovotestis is present in star-nosed and hairy-tailed moles, but not in broad-footed and Japanese shrew moles. Using histology, three-dimensional reconstruction, and morphometric analysis, sexual dimorphism was examined with regard to a nine feature masculine trait score that included perineal appendage length (prepuce), anogenital distance, and presence/absence of bone. The presence/absence of ovotestes was discordant in all four mole species for sex differentiation features. For many sex differentiation features, discordance with ovotestes was observed in at least one mole species. The degree of concordance with ovotestes was highest for hairy-tailed moles and lowest for broad-footed moles. In relationship to phylogenetic clade, sex differentiation features also did not correlate with the similarity/divergence of the features and presence/absence of ovotestes. Hairy-tailed and Japanese shrew moles reside in separated clades, but they exhibit a high degree of congruence. Broad-footed and hairy-tailed moles reside within the same clade but had one of the lowest correlations in features and presence/absence of ovotestes. Thus, phylogenetic affinity and the presence/absence of ovotestes are poor predictors for most sex differentiation features within mole external genitalia

Diagnosis of occult tuberculosis in hematological malignancy by enumeration of antigen-specific T cells.

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Land Grant Application- Ewer, Jonathan (Vassalborough)

Land grant application submitted to the Maine Land Office for Jonathan Ewer for service in the Revolutionary War.https://digitalmaine.com/revolutionary_war_me_land_office/1313/thumbnail.jp