Modular Frobenius manifolds and their invariant flows

The space of Frobenius manifolds has a natural involutive symmetry on it: there exists a map $I$ which send a Frobenius manifold to another Frobenius manifold. Also, from a Frobenius manifold one may construct a so-called almost dual Frobenius manifold which satisfies almost all of the axioms of a Frobenius manifold. The action of $I$ on the almost dual manifolds is studied, and the action of $I$ on objects such as periods, twisted periods and flows is studied. A distinguished class of Frobenius manifolds sit at the fixed point of this involutive symmetry, and this is made manifest in certain modular properties of the various structures. In particular, up to a simple reciprocal transformation, for this class of modular Frobenius manifolds, the flows are invariant under the action of $I\,.

Assessing the potential for reopening a building stone quarry : Newbigging Sandstone Quarry, Fife

Newbigging Sandstone Quarry in Fife is one of a number of former quarries in the Burntisland- Aberdour district which exploited the pale-coloured Grange Sandstone from Lower Carboniferous rocks. The quarry supplied building stone from the late 19th century, working intermittently from 1914 until closure in 1937, and again when reopened in the 1970s to the 1990s. The stone was primarily used locally and to supply the nearby markets in the Scottish Central Belt. Historical evidence indicates that prior to sandstone extraction, the area was dominated by largescale quarrying and mining of limestone, and substantial sandstone quarrying is likely to have begun after the arrival of the main railway line in 1890. It is probable that removal of the sandstone was directly associated with limestone exploitation, and that the quarried sandstone was effectively a by-product of limestone production. Sandstone extraction was probably viable due to the existing limestone quarry infrastructure (workforce, equipment, transportation) and the high demand for building stone in Central Scotland in the late 19th century. The geology within Newbigging Sandstone Quarry is dominated by thick-bedded uniform sandstone with a wide joint spacing, well-suited for obtaining large blocks. However, a mudstone (shale) band is likely to be present within a few metres of the principal (north) face of the quarry, around which the sandstone bed thickness and quality is likely to decrease. The mudstone bed forms a plane sloping at a shallow angle to the north, so that expansion of the quarry in this direction is likely to encounter a considerable volume of poor quality stone. Additionally, an east-west trending fault is present approximately 100 metres north of the quarry face, which is also likely to be associated with poor quality (fractured) stone

Case management training needs to support vocational rehabilitation for case managers and general practitioners: a survey study

<b>Background</b><p></p> The use of the biopsychosocial model of health and case management for effective vocational rehabilitation (VR) has been confirmed for many health conditions. While Case and Condition Managers (CCMPs) use this approach in their everyday work, little is known about their views on training needs. A review of the training curriculum for General Practitioners’ (GPs) revealed little training in VR and the biopsychosocial model of care. This study aims to identify Case and Condition Managers and GPs perceptions of their training needs in relation to employability and VR.<p></p> <b>Methods</b><p></p> 80 Case and Condition Managers and 304 GPs working in NHS Lanarkshire, providing a comparison group, were invited to participate in this study. A self-completion questionnaire was developed and circulated for online completion with a second round of hardcopy questionnaires distributed.<p></p> <b>Results</b><p></p> In total 45 responses were obtained from CCMPs, 5 from occupational health nurses (62% response rate) and 60 from GPs (20% response rate). CCMPs and the nursing group expressed a need for training but to a lesser extent than GP’s. The GP responses demonstrated a need for high levels of training in case/condition management, the biopsychosocial model, legal and ethical issues associated with employment and VR, and management training.<p></p> <b>Conclusions</b><p></p> This survey confirms a need for further training of CCMPs and that respondent GPs in one health board are not fully equipped to deal with patients employability and vocational needs. GPs also reported a lack of understanding about the role of Case and Condition managers. Training for these professional groups and others involved in multidisciplinary VR could improve competencies and mutual understanding among those advising patients on return-to-work

Draft genome sequence of the Streptococcus pneumoniae Avery strain A66

We have used HiSeq 2000 technology to generate a draft genome sequence of Streptococcus pneumoniae strain A66. This is a common study strain used in investigations of pneumococcal bacterium-host interactions and was used in the seminal genetic studies of Avery et al

Diagnosis of an anaerobic pond treating temperate domestic wastewater: An alternative sludge strategy for small works

An anaerobic pond (AP) for treatment of temperate domestic wastewater has been studied as a small works sludge management strategy to challenge existing practice which comprises solids separation followed by open sludge storage, for up to 90 days. During the study, effluent temperature ranged between 0.1 °C and 21.1 °C. Soluble COD production was noted in the AP at effluent temperatures typically greater than 10 °C and was coincident with an increase in effluent volatile fatty acids (VFA) concentration, which is indicative of anaerobic degradation. Analysis from ports sited along the AP's length, demonstrated VFA to be primarily formed nearest the inlet where most solids deposition initially incurred, and confirmed the anaerobic reduction of sludge within this chamber. Importantly, the sludge accumulation rate was 0.06 m3 capita−1 y−1 which is in the range of APs operated at higher temperatures and suggests a de-sludge interval of 2.3–3.8 years, up to 10 times longer than current practice for small works. Coincident with the solids deposition profile, biogas production was predominantly noted in the initial AP section, though biogas production increased further along the AP's length following start-up. A statistically significant increase in mean biogas production of greater than an order of magnitude was measured between winters (t(n=19) = 5.52, P < 0.001) demonstrating continued acclimation. The maximum methane yield recorded was 2630 mgCH4 PE−1 d−1, approximately fifty times greater than estimated from sludge storage (57 mgCH4 PE−1 d−1). Anaerobic ponds at small works can therefore enable sludge reduction and longer sludge holding times than present thus offsetting tanker demand whilst reducing fugitive methane emissions currently associated with sludge storage, and based on the enhanced yield noted, could provide a viable opportunity for local energy generation

Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60

The S. pombe Rad60 protein is required for the repair of DNA double strand breaks, recovery from replication arrest, and is essential for cell viability. It has two SUMO-like domains (SLDs) at its C-terminus, an SXS motif and three sequences that have been proposed to be SUMO-binding motifs (SBMs). SMB1 is located in the middle of the protein, SBM2 is in SLD1 and SBM3 is at the C-terminus of SLD2. We have probed the functions of the two SUMO-like domains, SLD1 and SLD2, and the putative SBMs. SLD1 is essential for viability, while SLD2 is not. rad60-SLD2Δ cells are sensitive to DNA damaging agents and hydroxyurea. Neither ubiquitin nor SUMO can replace SLD1 or SLD2. Cells in which either SBM1 or SBM2 has been mutated are viable and are wild type for response to MMS and HU. In contrast mutation of SBM3 results in significant sensitivity to MMS and HU. These results indicate that the lethality resulting from deletion of SLD1 is not due to loss of SBM2, but that mutation of SBM3 produces a more severe phenotype than does deletion of SLD2. Using chemical denaturation studies, FPLC and dynamic light scattering we show this is likely due to the destabilisation of SLD2. Thus we propose that the region corresponding to the putative SBM3 forms part of the hydrophobic core of SLD2 and is not a SUMO-interacting motif. Over-expression of Hus5, which is the SUMO conjugating enzyme and known to interact with Rad60, does not rescue rad60-SLD2Δ, implying that as well as having a role in the sumoylation process as previously described [1], Rad60 has a Hus5-independent function

Development of sustainable georesources for the built environment in the United Kingdom

The character of the UK’s built heritage has been largely determined by the country’s diverse geology. Indigenous natural stone forms a major component of the nation’s pre-1919 building stock. Stone has been used traditionally for roofing, roads, pavements, bridges, engineering works, and all forms of walling. Today it is mostly employed as thin panel cladding to concrete frameworks in modern construction and is now increasingly being used in large volumes for new city streetscapes.This paper outlines the material requirements for the repair and maintenance of the stone-built heritage and illustrates a range of initiatives across the UK aimed at safeguarding and redeveloping indigenous resources. The importance, particularly for the repair and conservation sector, of selecting appropriate replacement stone is being recognized by architectural and conservation professionals and by local authority officials. There is also increasing recognition of the importance to the economy of the local character of the built environment in terms of its value to tourism and to architectural, historical, and cultural identity. The paper also examines the historical sources of information on stone in the UK and offers recommendations for databasing and disseminating stone resource information. This may assist the redevelopment of a healthy indigenous stone industry and ensure that the unique built heritage character of the UK is maintained and enhanced