Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study

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The role of magnesium in the endothelial dysfunction caused by global ischemia followed by reperfusion: in vitro study of canine coronary arteries

Objective-To study the role of magnesium in the endothelial dysfunction of canine coronary arteries caused by cardiopulmonary bypass (CPB) global ischemia followed by reperfusion. Design-Segments of canine coronary arteries were suspended in organ chambers to measure isometric contraction by prostaglandin F-2alpha, and relaxed by acetylcholine (ACh), sodium fluoride (NaF), calcium ionophore (A(23187)) and sodium nitroprusside (SNP) in crescent concentrations. The investigation protocol had groups with six dogs: CONTROL group (without CPB), CPB group (105 min of CPB without aortic cross-clamping), ISCH group (45 min of CPB with aortic cross-clamping), ISCH/REP group (45 min of aortic cross-clamping followed by 60 min of reperfusion). The coronary relaxations were evaluated with (phase I), without (phase II) and restored magnesium (phase III) to the organ bath. Results-The presence of magnesium in the organ bath was associated with the greater relaxation in response to agonists of the nitric oxide production. The removal of magnesium from the organ bath was associated with the reduction in the intensity of vessel relaxation. The magnesium restoration to the organ bath was associated with the additional reduction in the intensity of relaxation with the exception of NaF that allowed reacquisition of the relaxation observed in the presence of magnesium. Conclusion-This in vitro study demonstrates that magnesium ion favorably influences the nitric oxide production by the coronary endothelium, attenuating the endothelial dysfunction caused by global ischemia followed by reperfusion.37528829

The impacts of asynchronous classes during the acclimatizing and upskilling periods in health work immersion 1 to the career decision-making in the aspects of interest and skill of grade 12 senior high school students in De La Salle Medical and Health Sciences Institute

The K-12 curriculum has administered the specialized Work Immersion subject to promote expertise and occupational growth. However, due to COVID-19, online learning systems were implemented which may hinder the students’ career decision-making given its inaccessibility to resources and expertise. With that, the descriptive study investigated the impacts of asynchronous classes during the Acclimatizing and Upskilling periods of Health Work Immersion (HWI) 1 upon the career decision-making (CD-M) in the aspects of interest and skill. The researchers adapted concepts from credible sources to form a 9-point quantitative survey indicating the CD-M difficulties. A total of 348 respondents was garnered with an equal allocation of 58 grade 12 students per enlisted college for upskilling. The results showcased that the CD-M difficulties mean score for interest was 4.591 while for skill was 4.878; both had low standard deviations. Among the CD-M difficulties levels, the larger fraction of the respondents accumulated moderate to salient difficulties with 321 students (moderate) and 14 students (salient) upon interest while 309 students (moderate) and 30 students (salient) upon skill. Overall, moderate CD-M difficulties were interpreted for interest and skill; hence, the students will require some attention from career counselors as impacted by the asynchronous classes in HWI 1