Comparison study on the properties of the CaP coatings formed by RF-magnetron sputtering of the Mg- and Sr-substituted ß-tricalcium phosphate and hydroxyapatite

This article describes the influence of Mg and Sr substitutions in the structure of -tricalcium phosphate and hydroxyapatite powder targets on the deposition rate of coatings formed via RF-magnetron sputtering and their properties. It was revealed that even low doses of ionic substitutions in -tricalcium phosphate significantly affect deposition rate, morphology and physico-chemical properties of respective coatings. Similar doses of these substitutions in hydroxyapatite are not enough to influence the deposition rate, but they affect coating properties

Composite biphase coatings formed by hybrid technology for biomedical applications

Calcium-phosphate (CaP) coatings were formed via combining methods of microarc oxidation (MAO) and radiofrequency magnetron sputtering (RFMS). SEM, XPS, XRD and nanoindentation methods were used to study physico-chemical and mechanical properties of the coatings. It was revealed that the upper CaP layer changes the morphology of the coatings at the microscale and increases the Ca/P ratio of biphasic coatings

Influence of magnesium and strontium substitutions in the structure of hydroxyapatite lattice on the deposition rate and properties of the CaP coatings formed via RF-sputtering of the powder targets

This work is dedicated to studying of the properties of the calcium phosphate (CaP) coatings deposited on Ti substrates by radio-frequency magnetron sputtering (RFMS) of three hydroxyapatite-based powder targets: pure hydroxyapatite (HA), Mg-substituted HA (Mg-HA, Mg = 0.93 ± 0.13 at.%) and Sr-substituted HA (Sr-HA, Sr ∼ 0.47 at.%). The influence of ionic substitutions in the structure of the sputtered targets on the surface morphology, physicochemical properties of the coatings and their wettability were studied. It is revealed that Mg and Sr ionic substitutions in the crystal lattice of HA at these concentrations don't affect deposition rate, however, it influences morphology, wettability and elemental and phase composition of deposited coatings

Modification of PCL scaffolds by reactive magnetron sputtering: a possibility for modulating macrophage responses

Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ε-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity

Modification of the Ceramic Implant Surfaces from Zirconia by the Magnetron Sputtering of Different Calcium Phosphate Targets: A Comparative Study

In this study, thin calcium phosphate (Ca-P) coatings were deposited on zirconia substrates by radiofrequency (RF) magnetron sputtering using different calcium phosphate targets (calcium phosphate tribasic (CPT), hydroxyapatite (HA), calcium phosphate monobasic, calcium phosphate dibasic dehydrate (DCPD) and calcium pyrophosphate (CPP) powders). The sputtering of calcium phosphate monobasic and DCPD powders was carried out without an inert gas in the self-sustaining plasma mode. The physico-chemical, mechanical and biological properties of the coatings were investigated. Cell adhesion on the coatings was examined using mesenchymal stem cells (MSCs). The CPT coating exhibited the best cell adherence among all the samples, including the uncoated zirconia substrate. The cells were spread uniformly over the surfaces of all samples