Complex Interplay of Evolutionary Forces in the ladybird Homeobox Genes of Drosophila melanogaster

Tandemly arranged paralogous genes lbe and lbl are members of the Drosophila NK homeobox family. We analyzed population samples of Drosophila melanogaster from Africa, Europe, North and South America, and single strains of D. sechellia, D. simulans, and D. yakuba within two linked regions encompassing partial sequences of lbe and lbl. The evolution of lbe and lbl is highly constrained due to their important regulatory functions. Despite this, a variety of forces have shaped the patterns of variation in lb genes: recombination, intragenic gene conversion and natural selection strongly influence background variation created by linkage disequilibrium and dimorphic haplotype structure. The two genes exhibited similar levels of nucleotide diversity and positive selection was detected in the noncoding regions of both genes. However, synonymous variability was significantly higher for lbe: no nonsynonymous changes were observed in this gene. We argue that balancing selection impacts some synonymous sites of the lbe gene. Stability of mRNA secondary structure was significantly different between the lbe (but not lbl) haplotype groups and may represent a driving force of balancing selection in epistatically interacting synonymous sites. Balancing selection on synonymous sites may be the first, or one of a few such observations, in Drosophila. In contrast, recurrent positive selection on lbl at the protein level influenced evolution at three codon sites. Transcription factor binding-site profiles were different for lbe and lbl, suggesting that their developmental functions are not redundant. Combined with our previous results on nucleotide variation in esterase and other homeobox genes, these results suggest that interplay of balancing and directional selection may be a general feature of molecular evolution in Drosophila and other eukaryote genomes

Integral Analysis of RCA of Irkutsk Region Companies

The financial position of a company depends on its liquidity, or otherwise, on how soon the funds invested in the assets turn into real money. The growth of non-payments complicates the company’s rhythmic activities (purchase of raw materials, payment of labor and other expenses generated from revenue) and leads to an increase in accounts receivable. At the same time, excessive diversion of funds to production stocks, work in progress, finished products, etc. leads to the deadening of resources and inefficient use of working capital. Successful solution of the problem of working capital optimization can significantly increase the financial stability of the company, refinance and repay the debt, and significantly facilitate debt restructuring. Therefore, effective management of the company’s working capital is the key to increasing the turnover of property and sales volumes. It involves not only the search for and attraction of additional sources of financing, but also their rational placement in the current assets of the company. The article presents the author’s model of analyzing the profitability of working capital. The article reveals the influence of factors affecting the profitability of working capital and author’s methodical approach to his calculations (method # 2 integral factor analysis, developed by Filatov E.A.). The article presents the author’s analytical, systematic statistical analysis of key performance indicators reveal the influence to change the profitability of working capital of the companies in the Irkutsk region of the Russian Federation

Methodology of profiling network operations in software for distributed information systems

Network operations take up large amounts of resources in distributed systems and in this case, existing profilers can correctly construct the execution tree of the program code and correctly identify the runtime, so you need other methods that will allow finding bottlenecks in the. The article discusses various approaches on the time efficiency assessment software, and based on a new method for profiling distributed systems, also an example of its use on a system built with agent technology-relational mapping. As a demonstration of the proposed method there’s presented an example of the system, built using the technology of agent-relational mapping that performs network operations in distributed transactions. Thus showing that for the ease of using this technology we have to pay with lots of operations to monitor network transactions

Methodology of profiling network operations in software for distributed information systems

Network operations take up large amounts of resources in distributed systems and in this case, existing profilers can correctly construct the execution tree of the program code and correctly identify the runtime, so you need other methods that will allow finding bottlenecks in the. The article discusses various approaches on the time efficiency assessment software, and based on a new method for profiling distributed systems, also an example of its use on a system built with agent technology-relational mapping. As a demonstration of the proposed method there’s presented an example of the system, built using the technology of agent-relational mapping that performs network operations in distributed transactions. Thus showing that for the ease of using this technology we have to pay with lots of operations to monitor network transactions

Electrical Conductivity of Melts Containing Rare-Earth Halides. II. MCl-PrCl3 (M = Li, Rb, Cs)

International audienceThe specific conductivity of molten LiCl-PrCl3, RbCl-PrCl3, and CsCl-PrCl3 was measured from the liquidus temperature up to similar to 1180 K by a conventional ac technique. The molar conductivity Lambda was calculated by using literature data on the densities of the binary systems. In all cases, it was found that the plot ln Lambda vs. 1/T is not a straight line. Thereby the activation energy of the conductivity does not remain constant but reduces with increasing temperature. In the specific and molar conductivity isotherms, strong deviations from additivity are observed with maxima in a range 35-45 mol. % PrCl3. The results conform to the idea of dominating octahedral local coordination of Pr3+ ions over the entire concentration range

Determination of the Degree of Crystallinity of Poly(2-methyl-2-oxazoline)

A new method for purification of 2-methyl-2-oxazoline using citric acid was developed and living cationic ring-opening polymerization of 2-methyl-2-oxazoline was carried out. Polymerization was conducted in acetonitrile using benzyl chloride—boron trifluoride etherate initiating system. According to DSC data, the temperature range of melting of the crystalline phase of the resulting polymer was 95–180 °C. According to small-angle X-ray scattering and wide-angle X-ray diffraction data, the degree of crystallinity of the polymer was 12%. Upon cooling of the polymer melt, the polymer became amorphous. Using thermogravimetric analysis, it was found that the thermal destruction of poly(2-methyl-2-oxazoline) started above 209 °C

Curing of Epoxy Resin DER-331 by Hexakis(4-acetamidophenoxy)cyclotriphosphazene and Properties of the Prepared Composition

The method of optical wedge revealed that the optimum temperature for compatibility of hexakis(4-acetamidophenoxy)cyclotriphosphazene (ACP) and DER-331 epoxy resin is in the range of 220–260 °C. The interdiffusion time of components at these temperatures is about 30 min. The TGA and differential scanning calorimetry (DSC) methods revealed the curing temperature of 280 °С for this composition. IR spectroscopy confirmed that the reaction between the resin and ACP is completed within 10 min. According to the DSC data, a glass transition temperature of 130 °С was estimated for the cured resin. Combustion test UL-94 demonstrated that the obtained material can be assigned to the fireproof category of V-0. Burning droplets were not formed during the burning. The coke formed during the combustion of samples possessed a dense and porous structure. The shape of pores is closed, while their size is in the range of 0.2–200 µm

Spin transparency mode in the NICA collider

The NICA collider can operate with polarized light ions in two modes. At the Preferred Spin mode (PS mode) the periodic spin motion along the closed orbit is unique, i.e. the static magnetic lattice determines a single stable orientation of the beam polarization at any collider's place. At the Spin Transparency mode (ST mode) any spin direction repeats every particle turn along the closed orbit, i.e. the colliders magnetic lattice is transparent to the spin. ST mode allows one to use a completely new approach to carry out experiments with polarized ions at high precision level. The features of ion polarization control in the ST mode are discussed. The schemes of polarization control in the NICA collider in the ST mode are presented