Maša Mlinarič - Forma v gibanju

Mrežno ali geometrijsko naravnani prostor slikovnega polja in njegov »podaljšek« v razširjeno sliko – v slikarski objekt (B. Riley, V. Richter, D. Jejčič), se v povezovalnem študijskem procesu formira najprej kot izkušnja z risbo in nato kot slikarska izkušnja. Oboje se ob izpitu nato vzporedno artikulira v znanju, s široko oporo likovne teorije (V. Vasarelly- Op Art in entnografska povezava z tradicionalnimi vezeninami), s področjem umetnostne zgodovine ter z drugimi povezavami, kot je prostorsko oblikovanje ali področje glasbe (P. Mondrian-»Bugi Wugi«) ali skozi signalistično poezijo (Zagoričnik-»West Est«), ki se nato kot refleksija izgovarja kot priprava v učnih načrtih

Novel Water-Soluble Amphotericin B‑PEG Conjugates with Low Toxicity and Potent <i>in Vivo</i> Efficacy

Systemic fungal infections are an increasingly prevalent health problem, especially among immunocompromised patients. Antifungal drug development lags far behind in comparison to other types of antimicrobial drugs. Current commercially available antifungals are limited by their insufficient potency, side effects, drug–drug interactions, developing drug-resistance, and narrow formulation options. Here, we report the preparation and evaluation of two novel PEG amide conjugates of amphotericin B (AMB (<b>1</b>)): AB1 (<b>4</b>) and AM2 (<b>5</b>). These compounds are nonlabile, they are prepared in only two and three synthetic steps, respectively, and they show antifungal activity against a wide range of clinical fungal isolates. Their toxicity is significantly lower, and their water solubility is up to 5000-fold higher than that of AMB (<b>1</b>). <i>In vivo</i> efficacy studies in a mouse model of systemic candidiasis showed that AM2 (<b>5</b>) successfully cured all the mice at concentrations above 3.5 mg/kg body weight. In conclusion, these properties make AB1 (<b>4</b>) and AM2 (<b>5</b>) promising candidates for clinical use