Magnetic structure and phase diagram of TmB4

Magnetic structure of single crystalline TmB4 has been studied by magnetization, magnetoresistivity and specific heat measurements. A complex phase diagram with different antiferromagnetic (AF) phases was observed below TN1 = 11.7 K. Besides the plateau at half-saturated magnetization (1/2 MS), also plateaus at 1/9, 1/8 and 1/7 of MS were observed as function of applied magnetic field B//c. From additional neutron scattering experiments on TmB4, we suppose that those plateaus arise from a stripe structure which appears to be coherent domain boundaries between AF ordered blocks of 7 or 9 lattice constants. The received results suggest that the frustration among the Tm3+ magnetic ions, which maps to a geometrically frustrated Shastry-Sutherland lattice lead to strong competition between AF and ferromagnetic (FM) order. Thus, stripe structures in intermediate field appear to be the best way to minimize the magnetostatic energy against other magnetic interactions between the Tm ions combined with very strong Ising anisotropy.Comment: 4 pages, 4 figures, conference contribution - CSMAG 0

MANAGEMENT DECISION-MAKING IN THE TRANSFORMATION OF HIGHER EDUCATION

The main directions of the transformation of higher education in the Russian Federation. Clarifications on the role of leadership in the management decision-making in higher education. The formation of a broad group of larger competitive at the national level, regional universities and their focus on quality training of specialists in demand on the regional labor market. Obtained problem management decision-making, strategy development and their relationship with the state policy in the sphere of higher education

MANAGEMENT DECISION-MAKING IN THE TRANSFORMATION OF HIGHER EDUCATION

The main directions of the transformation of higher education in the Russian Federation. Clarifications on the role of leadership in the management decision-making in higher education. The formation of a broad group of larger competitive at the national level, regional universities and their focus on quality training of specialists in demand on the regional labor market. Obtained problem management decision-making, strategy development and their relationship with the state policy in the sphere of higher education

Development of a New Dosage Form of Herbal Medicinal Products

The «cut-and-pressed granules» dosage form was developed to improve the technological properties of cut and powdered herbal substances in order to compensate for their insufficient flowability, as well as to facilitate dosing, reduce the contamination of the production equipment with dust and contamination of water extracts with dietary fibers. Based on the results of the information research the authors chose an optimal technology for the production of cut-and-pressed granules from some types of herbal substances (Rose hips, Bearberry leaf, Thyme herb, Melissa herb, Oregano herb, Motherwort grass, Matricaria flower). The authors standardised the new dosage form, developed the list of test parameters, test methods, and regulatory requirements for the quality of medicinal products based on the technological features of the new dosage form. Cut-and-pressed granules should not be produced from herbal substances that contain essential oils and coumarins, as it was demonstrated that the content of these compounds may decrease in the process of wet granulation. To determine whether it is possible to produce cut-and-pressed granules from a particular type of raw material, it is necessary to conduct comparative experimental studies confirming that the quality of aqueous extracts obtained from powdered herbal substances in sachets is comparable to that of tinctures or decoctions obtained from cut-and-pressed granules packed in sachets. The materials of the study were used to draft the general chapter OFS.1.4.1.0022.15 «Cut-and-pressed granules». This dosage form is not described in any foreign pharmacopoeias

The role of the state in the financing sources’ formation of industrial enterprises’ innovative activities

Currently, the external conditions for the functioning of industrial enterprises are formed in such a way that the achievement of their goals is seen impossible without the implementation of innovative activities. Due to the high cost of innovations, as well as the need to conduct these processes on an ongoing basis, industrial enterprises lack their own funds to finance innovation activities. The state is interested in the innovative development of industrial enterprises. This is one of the reasons why it participates in the formation of their funding sources. The article substantiates the need for state support, as well as analyzes the options for its provision by type of financing sources. For each type of sources, options for providing large-scale support, implying a large coverage area, as well as point-directed support, are also highlighted

«Ten Questions a Hundred Famous Russian People» as Format Student Television Broadcasting

The article is devoted to the problems of designing television broadcasting for students NWIM RANEPA by example implementation of the television project «Ten questions a hundred famous Russian people». This media product has its own unique. It is created from beginning to the end by the students themselves, studying in the field of training “Journalism” NWIM RANEPA. The authors of the article comprehensively analyzed all technological and creative aspects of this project. In their opinion, the project «Ten questions a hundred famous Russian people» became an experimental platform where the most brave decisions and approaches in studying autobiographies of famous people were tested, where students can engage in self-directed practice activities and mastering of various television specialties: cameraman, producer, TV presenter, editor, sound engineer, screenwriter, correspondent, editor. Therefore the project harmonically joined in the educational process to carry out educational and enlightening functions

Проблемное обучение в дистанционном формате как метод формирования клинического мышления обучающихся ординатуры медицинского вуза

Introduction. The paper examines the problem of the formation of clinical thinking of a medical specialist in a remote format, identifies ways and means of its solution.Purpose setting. It is important to reveal a contradiction between the development of professional medical skills in practice and the lack of direct contact with the patient in remote interaction, where students of medical universities face the problem of the impossibility of contact with the patient, which, in turn, complicates the formation of their clinical thinking and, in the future, negatively affects the work of the doctor.Methodology and methods of the study. Experimental work is being carried out to study the practical application of problem-based learning techniques in the distance format of residency students in the formation of their clinical thinking. The pedagogical conditions associated with the use of problem-based learning methods in the formation of clinical thinking of students in residency are substantiated and proposed. 54 first-year resident doctors in various clinical specialties participated in the study as respondents. The study was conducted in November 2021 during the period of study in the discipline «Pedagogy».Results. As a result of the work carried out, conclusions are drawn that the practical application of problem-based learning techniques, as a method of forming clinical thinking in distance learning, has a certain educational effect. In a remote format, this technique transfers students in residency from listeners of subject material to active participants in educational work, allowing them to form clinical thinking in conditions of limited communication with patients.Conclusion. In the course of experimental work, it was found out that the distance learning format during the pandemic gave many resident doctors the opportunity to become part of the practical level of healthcare, having the possibility to combine study and work.Введение. В работе исследуется проблема формирования клинического мышления медицинского специалиста в дистанционном формате, определяются пути и способы решения.Постановка задачи. Важно выявить противоречие, которое находится между отработкой профессиональных медицинских навыков на практике и отсутствием прямого контакта с пациентом в дистанционном взаимодействием, где обучающиеся медицинских вузов сталкиваются с проблемой невозможности контакта с пациентом, что, в свою очередь, затрудняет формирование у них клинического мышления и в дальнейшем негативно сказывается на работе врача.Методика и методология исследования. Проводится опытно-экспериментальная работа по изучению практического применения методик проблемного обучения в дистанционном формате обучающихся ординатуры при формировании у них клинического мышления. Обосновываются и предлагаются педагогические условия, связанные с применением методов проблемного обучения в формировании клинического мышления обучающихся в ординатуре. В качестве респондентов в исследовании приняло участие 54 врача-ординатора первого года обучения по различным клиническим специальностям. Исследование проводилось в ноябре 2021 г. в период обучения дисциплине «Педагогика».Результаты. В результате проведенной работы делаются выводы о том, что практическое применение методик проблемного обучения как метода формирования клинического мышления в условиях дистанционного обучения имеет определенный образовательный эффект. В дистанционном формате эта методика переводит обучающихся в ординатуре из слушателей предметного материала в активных участников учебной работы, позволяя формировать клиническое мышление в условиях ограниченного общения с пациентами.Выводы. В ходе опытно-экспериментальной работы выяснено, что дистанционный формат обучения в период пандемии дал многим врачам-ординаторам возможность стать частью практического звена здравоохранения, получив возможность совмещения учебы и работы

RET Rearrangements in Lung Adenocarcinoma and Radiation

Background:RET rearrangement, a hallmark of radiation-induced thyroid cancer, has been reported to occur in 1% of lung adenocarcinoma patients. Patients with this rearrangement tend to be younger and never smokers, raising a possibility of other causes, such as radiation. We hypothesized that RET chromosomal rearrangement may represent a genetic mechanism of radiation-induced lung cancer.Methods:Two hundred forty-five consecutive primary lung adenocarcinomas without history of radiation and 38 lung adenocarcinoma patients with a history of therapeutic radiation for breast carcinoma or mediastinal Hodkgin lymphoma were tested for RET rearrangement by fluorescence in situ hybridization. Human lung adenocarcinoma cells (201T) were subjected to γ radiation and tested for RET gene fusions by reverse transcriptase-polymerase chain reaction and Southern blot hybridization.Results:We identified one case with RET rearrangement in the group without history of radiation (1 of 240; 0.4%) and two cases in the group with history of radiation (2 of 37; 5.4%; P=0.0436). Both these patients were women, who were former smokers with a history of breast carcinoma treated with surgery and radiation. Furthermore, we found that RET fusions could be directly induced in 201T human lung cells by exposure to 1 Gy of γ radiation. All fusions identified were between RET and KIF5B genes, and no RET fusions to CCDC6 or NCOA4 genes, characteristic for thyroid cancer, were identified in the irradiated lung cells.Conclusion:RET fusions may represent a genetic mechanism of radiation-induced lung adenocarcinoma