Rules for transition rates in nonequilibrium steady states

Just as transition rates in a canonical ensemble must respect the principle of detailed balance, constraints exist on transition rates in driven steady states. I derive those constraints, by maximum information-entropy inference, and apply them to the steady states of driven diffusion and a sheared lattice fluid. The resulting ensemble can potentially explain nonequilibrium phase behaviour and, for steady shear, gives rise to stress-mediated long-range interactions.Comment: 4 pages. To appear in Physical Review Letter

Detailed balance has a counterpart in non-equilibrium steady states

When modelling driven steady states of matter, it is common practice either to choose transition rates arbitrarily, or to assume that the principle of detailed balance remains valid away from equilibrium. Neither of those practices is theoretically well founded. Hypothesising ergodicity constrains the transition rates in driven steady states to respect relations analogous to, but different from the equilibrium principle of detailed balance. The constraints arise from demanding that the design of any model system contains no information extraneous to the microscopic laws of motion and the macroscopic observables. This prevents over-description of the non-equilibrium reservoir, and implies that not all stochastic equations of motion are equally valid. The resulting recipe for transition rates has many features in common with equilibrium statistical mechanics.Comment: Replaced with minor revisions to introduction and conclusions. Accepted for publication in Journal of Physics

Force dependent fragility in RNA hairpins

We apply Kramers theory to investigate the dissociation of multiple bonds under mechanical force and interpret experimental results for the unfolding/refolding force distributions of an RNA hairpin pulled at different loading rates using laser tweezers. We identify two different kinetic regimes depending on the range of forces explored during the unfolding and refolding process. The present approach extends the range of validity of the two-states approximation by providing a theoretical framework to reconstruct free-energy landscapes and identify force-induced structural changes in molecular transition states using single molecule pulling experiments. The method should be applicable to RNA hairpins with multiple kinetic barriers.Comment: Latex file, 4 pages+3 figure

Work probability distribution in single molecule experiments

We derive and solve a differential equation satisfied by the probability distribution of the work done on a single biomolecule in a mechanical unzipping experiment. The unzipping is described as a thermally activated escape process in an energy landscape. The Jarzynski equality is recovered as an identity, independent of the pulling protocol. This approach allows one to evaluate easily, by numerical integration, the work distribution, once a few parameters of the energy landscape are known.Comment: To appear on EP

The Nature of the Compact/Symmetric Near-IR Continuum Source in 4C 40.36

Using NICMOS on HST, we have imaged the emission-line nebulae and the line-free continuum in 4C 40.36, a ultra-steep spectrum FR II radio galaxy at z=2.269. The line-free continuum was found to be extremely compact and symmetric while the emission-line nebulae seen in H-alpha+[N II] show very clumpy structures spreading almost linearly over 16 kpc. However, this linear structure is clearly misaligned from the radio axis. The SED of the line-free continuum is very flat, suggesting that if the continuum emission is produced by a single source, it is likely to be a young bursting stellar population or scattered AGN light. However, because of the lack of a line-free optical image with a comparable spatial resolution, we cannot exclude the possibility that the observed SED is a composite of a young blue population and an old red population.Comment: 4 pages, 2 figures; to appear in the proceedings of "The Hy-Redshift Universe: Galaxy Formation and Evolution at High Redshift", eds. A.J.Bunker and W. J. M. van Breuge

An exactly solvable dissipative transport model

We introduce a class of one-dimensional lattice models in which a quantity, that may be thought of as an energy, is either transported from one site to a neighbouring one, or locally dissipated. Transport is controlled by a continuous bias parameter q, which allows us to study symmetric as well as asymmetric cases. We derive sufficient conditions for the factorization of the N-body stationary distribution and give an explicit solution for the latter, before briefly discussing physically relevant situations.Comment: 7 pages, 1 figure, submitted to J. Phys.

Representations of p-brane topological charge algebras

The known extended algebras associated with p-branes are shown to be generated as topological charge algebras of the standard p-brane actions. A representation of the charges in terms of superspace forms is constructed. The charges are shown to be the same in standard/extended superspace formulations of the action.Comment: 22 pages. Typos fixed, refs added. Minor additions to comments sectio

Ecosystem Approach to Small Scale Tropical Marine Fisheries

This is a 4-page brochure about a WorldFish led project. Throughout the world, poor fisheries management contributes to resource degradation, poverty, and food insecurity. This European Union project on an Ecosystem Approach to Small-scale Tropical Marine Fisheries is led by WorldFish and implemented in collaboration with national partners in Asia (Southeastern)-Indonesia; the Asia (Southeastern)-Philippines; the Solomon Islands and Tanzania. The overall objective is to use an ecosystem approach to fisheries management (EAFM) to improve governance of small-scale fisheries (SSF). The EAFM puts sustainability and equitability at the forefront of fisheries governance which enhances their contribution to poverty reduction.Specific objectives are to: 1. Assess existing institutional arrangements and identify opportunities for an EAFM to improve integrated SSF management; 2. Develop EAFM strategies and actions suitable for developing country contexts; 3. Strengthen the capacity of local fishery stakeholders and government agencies to collaborate and work within an EAFM. The project is taking a participatory and gender sensitive approach, both core philosophies of WorldFish. Representatives of all relevant stakeholder groups are involved in this action research project

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV

Protein microbicides containing neutralizing antibodies and antiviral lectins may help to reduce the rate of infection with human immunodeficiency virus (HIV) if it is possible to manufacture the components in large quantities at a cost affordable in HIV‐endemic regions such as sub‐Saharan Africa. We expressed the antiviral lectin griffithsin (GRFT), which shows potent neutralizing activity against HIV, in the endosperm of transgenic rice plants (Oryza sativa), to determine whether rice can be used to produce inexpensive GRFT as a microbicide ingredient. The yield of (OS)GRFT in the best‐performing plants was 223 μg/g dry seed weight. We also established a one‐step purification protocol, achieving a recovery of 74% and a purity of 80%, which potentially could be developed into a larger‐scale process to facilitate inexpensive downstream processing. (OS)GRFT bound to HIV glycans with similar efficiency to GRFT produced in Escherichia coli. Whole‐cell assays using purified (OS)GRFT and infectivity assays using crude extracts of transgenic rice endosperm confirmed that both crude and pure (OS)GRFT showed potent activity against HIV and the crude extracts were not toxic towards human cell lines, suggesting they could be administered as a microbicide with only minimal processing. A freedom‐to‐operate analysis confirmed that GRFT produced in rice is suitable for commercial development, and an economic evaluation suggested that 1.8 kg/ha of pure GRFT could be produced from rice seeds. Our data therefore indicate that rice could be developed as an inexpensive production platform for GRFT as a microbicide component