Nonequilibrium phase transition in a non integrable zero-range process

The present work is an endeavour to determine analytically features of the stationary measure of a non-integrable zero-range process, and to investigate the possible existence of phase transitions for such a nonequilibrium model. The rates defining the model do not satisfy the constraints necessary for the stationary measure to be a product measure. Even in the absence of a drive, detailed balance with respect to this measure is violated. Analytical and numerical investigations on the complete graph demonstrate the existence of a first-order phase transition between a fluid phase and a condensed phase, where a single site has macroscopic occupation. The transition is sudden from an imbalanced fluid where both species have densities larger than the critical density, to a critical neutral fluid and an imbalanced condensate

Nonequilibrium statistical mechanics of shear flow: invariant quantities and current relations

In modeling nonequilibrium systems one usually starts with a definition of the microscopic dynamics, e.g., in terms of transition rates, and then derives the resulting macroscopic behavior. We address the inverse question for a class of steady state systems, namely complex fluids under continuous shear flow: how does an externally imposed shear current affect the microscopic dynamics of the fluid? The answer can be formulated in the form of invariant quantities, exact relations for the transition rates in the nonequilibrium steady state, as discussed in a recent letter [A. Baule and R. M. L. Evans, Phys. Rev. Lett. 101, 240601 (2008)]. Here, we present a more pedagogical account of the invariant quantities and the theory underlying them, known as the nonequilibrium counterpart to detailed balance (NCDB). Furthermore, we investigate the relationship between the transition rates and the shear current in the steady state. We show that a fluctuation relation of the Gallavotti-Cohen type holds for systems satisfying NCDB.Comment: 24 pages, 11 figure

Anxious/depressed symptoms are related to microstructural maturation of white matter in typically developing youths

AbstractThere are multiple recent reports of an association between anxious/depressed (A/D) symptomatology and the rate of cerebral cortical thickness maturation in typically developing youths. We investigated the degree to which anxious/depressed symptoms are tied to age-related microstructural changes in cerebral fiber pathways. The participants were part of the NIH MRI Study of Normal Brain Development. Child Behavior Checklist A/D scores and diffusion imaging were available for 175 youths (84 males, 91 females; 241 magnetic resonance imagings) at up to three visits. The participants ranged from 5.7 to 18.4 years of age at the time of the scan. Alignment of fractional anisotropy data was implemented using FSL/Tract-Based Spatial Statistics, and linear mixed model regression was carried out using SPSS. Child Behavior Checklist A/D was associated with the rate of microstructural development in several white matter pathways, including the bilateral anterior thalamic radiation, bilateral inferior longitudinal fasciculus, left superior longitudinal fasciculus, and right cingulum. Across these pathways, greater age-related fractional anisotropy increases were observed at lower levels of A/D. The results suggest that subclinical A/D symptoms are associated with the rate of microstructural development within several white matter pathways that have been implicated in affect regulation, as well as mood and anxiety psychopathology.</jats:p

Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis

Human adenovirus type 5 infection causes the disruption of structures in the cell nucleus termed promyelocytic leukaemia (PML) protein nuclear domains or ND10, which contain the PML protein as a critical component. This disruption is achieved through the action of the viral E4 Orf3 protein, which forms track-like nuclear structures that associate with the PML protein. This association is mediated by a direct interaction of Orf3 with a specific PML isoform, PMLII. We show here that the Orf3 interaction properties of PMLII are conferred by a 40 aa residue segment of the unique C-terminal domain of the protein. This segment was sufficient to confer interaction on a heterologous protein. The analysis was informed by prior application of a bioinformatic tool for the prediction of potential protein interaction sites within unstructured protein sequences (predictors of naturally disordered region analysis; PONDR). This tool predicted three potential molecular recognition elements (MoRE) within the C-terminal domain of PMLII, one of which was found to form the core of the Orf3 interaction site, thus demonstrating the utility of this approach. The sequence of the mapped Orf3-binding site on PML protein was found to be relatively poorly conserved across other species; however, the overall organization of MoREs within unstructured sequence was retained, suggesting the potential for conservation of functional interactions

Energy and pressure densities of a hot quark-gluon plasma

We calculate the energy and hydrostatic pressure densities of a hot quark-gluon plasma in thermal equilibrium through diagrammatic analyses of the statistical average, $\langle \Theta_{\mu \nu} \rangle$, of the energy-momentum-tensor operator $\Theta_{\mu \nu}$. To leading order at high temperature, the energy density of the long wave length modes is consistently extracted by applying the hard-thermal-loop resummation scheme to the operator-inserted no-leg thermal amplitudes $\langle \Theta_{\mu \nu} \rangle$. We find that, for the long wave length gluons, the energy density, being positive, is tremendously enhanced as compared to the noninteracting case, while, for the quarks, no noticeable deviation from the noninteracting case is found.Comment: 33 pages. Figures are not include

Young Children’s Ability to Describe Intermediate Clothing Placement

Children’s ability to adequately describe clothing placement is essential to evaluating their allegations of sexual abuse. Intermediate clothing placement (partially removed clothing) may be difficult for young children to describe, requiring more detailed explanations to indicate the location of clothing (e.g., the clothes were pulled down to the knees). The current study investigated 172 3- to 6-year-olds’ descriptions of clothing placement when responding to commonly used questions (yes/no, forced-choice, open-choice, where), as well as children’s on-off response tendencies when describing intermediate placement (i.e., labeling the clothing as fully on or off). Results revealed that where questions were superior in eliciting intermediate descriptions, even for the youngest children. Children sometimes exhibited tendencies to describe intermediate placements as “on” or “off,” which varied by question-type and clothing placement. The implications of the findings for interviewing young children about sexual abuse are discussed

Increased Oxidative Burden Associated with Traffic Component of Ambient Particulate Matter at Roadside and Urban Background Schools Sites in London

As the incidence of respiratory and allergic symptoms has been reported to be increased in children attending schools in close proximity to busy roads, it was hypothesised that PM from roadside schools would display enhanced oxidative potential (OP). Two consecutive one-week air quality monitoring campaigns were conducted at seven school sampling sites, reflecting roadside and urban background in London. Chemical characteristics of size fractionated particulate matter (PM) samples were related to the capacity to drive biological oxidation reactions in a synthetic respiratory tract lining fluid. Contrary to hypothesised contrasts in particulate OP between school site types, no robust size-fractionated differences in OP were identified due high temporal variability in concentrations of PM components over the one-week sampling campaigns. For OP assessed both by ascorbate (OPAA m−3) and glutathione (OPGSH m−3) depletion, the highest OP per cubic metre of air was in the largest size fraction, PM1.9–10.2. However, when expressed per unit mass of particles OPAA µg−1 showed no significant dependence upon particle size, while OPGSH µg−1 had a tendency to increase with increasing particle size, paralleling increased concentrations of Fe, Ba and Cu. The two OP metrics were not significantly correlated with one another, suggesting that the glutathione and ascorbate depletion assays respond to different components of the particles. Ascorbate depletion per unit mass did not show the same dependence as for GSH and it is possible that other trace metals (Zn, Ni, V) or organic components which are enriched in the finer particle fractions, or the greater surface area of smaller particles, counter-balance the redox activity of Fe, Ba and Cu in the coarse particles. Further work with longer-term sampling and a larger suite of analytes is advised in order to better elucidate the determinants of oxidative potential, and to fuller explore the contrasts between site types.\ud \u

X-ray Emission from Optically Selected Radio-Intermediate and Radio-Loud Quasars

We present the results of an investigation into the X-ray properties of radio-intermediate and radio-loud quasars (RIQs and RLQs, respectively). We combine large, modern optical (e.g., SDSS) and radio (e.g., FIRST) surveys with archival X-ray data from Chandra, XMM-Newton, and ROSAT to generate an optically selected sample that includes 188 RIQs and 603 RLQs. This sample is constructed independently of X-ray properties but has a high X-ray detection rate (85%); it provides broad and dense coverage of the l-z plane, including at high redshifts (22% of objects have z=2-5), and it extends to high radio-loudness values (33% of objects have R*=3-5, using logarithmic units). We measure the "excess" X-ray luminosity of RIQs and RLQs relative to radio-quiet quasars (RQQs) as a function of radio loudness and luminosity, and parameterize the X-ray luminosity of RIQs and RLQs both as a function of optical/UV luminosity and also as a joint function of optical/UV and radio luminosity. RIQs are only modestly X-ray bright relative to RQQs; it is only at high values of radio-loudness (R*>3.5) and radio luminosity that RLQs become strongly X-ray bright. We find no evidence for evolution in the X-ray properties of RIQs and RLQs with redshift (implying jet-linked IC/CMB emission does not contribute substantially to the nuclear X-ray continuum). Finally, we consider a model in which the nuclear X-ray emission contains both disk/corona-linked and jet-linked components and demonstrate that the X-ray jet-linked emission is likely beamed but to a lesser degree than applies to the radio jet. This model is used to investigate the increasing dominance of jet-linked X-ray emission at low inclinations.Comment: Accepted to ApJ; 42 pages, 21 figures, 10 tables; version with full-res figures at http://www.astro.lsa.umich.edu/~mbrendan/rlqx.htm

Stable isotope analysis provides new information on winter habitat use of declining avian migrants that is relevant to their conservation

Winter habitat use and the magnitude of migratory connectivity are important parameters when assessing drivers of the marked declines in avian migrants. Such information is unavailable for most species. We use a stable isotope approach to assess these factors for three declining African-Eurasian migrants whose winter ecology is poorly known: wood warbler Phylloscopus sibilatrix, house martin Delichon urbicum and common swift Apus apus. Spatially segregated breeding wood warbler populations (sampled across a 800 km transect), house martins and common swifts (sampled across a 3,500 km transect) exhibited statistically identical intra-specific carbon and nitrogen isotope ratios in winter grown feathers. Such patterns are compatible with a high degree of migratory connectivity, but could arise if species use isotopically similar resources at different locations. Wood warbler carbon isotope ratios are more depleted than typical for African-Eurasian migrants and are compatible with use of moist lowland forest. The very limited variance in these ratios indicates specialisation on isotopically restricted resources, which may drive the similarity in wood warbler populations' stable isotope ratios and increase susceptibility to environmental change within its wintering grounds. House martins were previously considered to primarily use moist montane forest during the winter, but this seems unlikely given the enriched nature of their carbon isotope ratios. House martins use a narrower isotopic range of resources than the common swift, indicative of increased specialisation or a relatively limited wintering range; both factors could increase house martins' vulnerability to environmental change. The marked variance in isotope ratios within each common swift population contributes to the lack of population specific signatures and indicates that the species is less vulnerable to environmental change in sub-Saharan Africa than our other focal species. Our findings demonstrate how stable isotope research can contribute to understanding avian migrants' winter ecology and conservation status