197 research outputs found
Simulations of the Micro-Bunching Instability for SOLEIL and KARA Using Two Different VFP Solver Codes
The longitudinal dynamics of a bunched electron beam is an important aspect in the study of existing and the development of new electron storage rings. The dynamics depend on different beam parameters as well as on the interaction of the beam with its surroundings. A well established method for calculating the resulting dynamics is to numerically solve the Vlasov-Fokker-Planck equation. Depending on the chosen parameters and the considered wakefields and impedances, different effects can be studied. One common application is the investigation of the longitudinal micro-wave and micro-bunching instabilities. The latter occurs for short electron bunches due to self-interaction with their own emitted coherent synchrotron radiation (CSR). In this contribution, two different VFP solvers are used to simulate the longitudinal dynamics with a focus on the micro-bunching instability at the Soleil synchrotron and the KIT storage ring KARA (Karlsruhe Research Accelerator)
Regina Lectures on Fat Points
These notes are a record of lectures given in the Workshop on Connections
Between Algebra and Geometry at the University of Regina, May 29--June 1, 2012.
The lectures were meant as an introduction to current research problems related
to fat points for an audience that was not expected to have much background in
commutative algebra or algebraic geometry (although sections 8 and 9 of these
notes demand somewhat more background than earlier sections).Comment: 32 pages, 3 figure
Coproducing Knowledge of the Implementation of Complex Digital Health Interventions for Adults with Acquired Brain Injury and their Communication Partners: Protocol for a Mixed Methods Study.
BACKGROUND: The Social Brain Toolkit, conceived and developed in partnership with stakeholders, is a novel suite of web-based communication interventions for people with brain injury and their communication partners. To support effective implementation, the developers of the Social Brain Toolkit have collaborated with people with brain injury, communication partners, clinicians, and individuals with digital health implementation experience to coproduce new implementation knowledge. In recognition of the equal value of experiential and academic knowledge, both types of knowledge are included in this study protocol, with input from stakeholder coauthors. OBJECTIVE: This study aims to collaborate with stakeholders to prioritize theoretically based implementation targets for the Social Brain Toolkit, understand the nature of these priorities, and develop targeted implementation strategies to address these priorities, in order to support the Social Brain Toolkit's implementation. METHODS: Theoretically underpinned by the Nonadoption, Abandonment, Scale-up, Spread, and Sustainability (NASSS) framework of digital health implementation, a maximum variation sample (N=35) of stakeholders coproduced knowledge of the implementation of the Social Brain Toolkit. People with brain injury (n=10), communication partners (n=11), and clinicians (n=5) participated in an initial web-based prioritization survey based on the NASSS framework. Survey completion was facilitated by plain English explanations and accessible captioned videos developed through 3 rounds of piloting. A speech-language pathologist also assisted stakeholders with brain injury to participate in the survey via video teleconference. Participants subsequently elaborated on their identified priorities via 7 web-based focus groups, in which researchers and stakeholders exchanged stakeholder perspectives and research evidence from a concurrent systematic review. Stakeholders were supported to engage in focus groups through the use of visual supports and plain English explanations. Additionally, individuals with experience in digital health implementation (n=9) responded to the prioritization survey questions via individual interview. The results will be deductively analyzed in relation to the NASSS framework in a coauthorship process with people with brain injury, communication partners, and clinicians. RESULTS: Ethical approval was received from the University of Technology Sydney Health and Medical Research Ethics Committee (ETH20-5466) on December 15, 2020. Data were collected from April 13 to November 18, 2021. Data analysis is currently underway, with results expected for publication in mid-2022. CONCLUSIONS: In this study, researchers supported individuals with living experience of acquired brain injury, of communicating with or clinically supporting someone post injury, and of digital health implementation, to directly access and leverage the latest implementation research evidence and theory. With this support, stakeholders were able to prioritize implementation research targets, develop targeted implementation solutions, and coauthor and publish new implementation findings. The results will be used to optimize the implementation of 3 real-world, evidence-based interventions and thus improve the outcomes of people with brain injury and their communication partners. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/35080
LUNEX5 : A FEL PROJECT TOWARDS THE FIFTH GENERATION IN FRANCE
ISBN978-3-95450-117-5 - http://accelconf.web.cern.ch/AccelConf/FEL2011/papers/tupa09.pdfInternational audienc
TRH: Pathophysiologic and clinical implications
Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin. ACTH and GH may increase in response to exogenous TRH in pituitary ACTH and GH hypersecretion syndromes and in some extrapituitary diseases.
The pathophysiological implications of extrahypothalamic TRH in humans are essentially unknown.
The TSH response to TRH is nowadays widely used as a diganostic amplifier in thyroid diseases being suppressed in borderline and overt hyperthyroid states and increased in primary thyroid failure. In hypothyroid states of hypothalamic origin, TSH increases in response to exogenous TRH often with a delayed and/or exaggerated time course.
But in patients with pituitary tumors and suprasellar extension TSH may also respond to TRH despite secondary hypothyroidism. This TSH increase may indicate a suprasellar cause for the secondary hypothyroidism, probably due to portal vessel occlusion. The TSH released in these cases is shown to be biologically inactive
A NEW SCHEME FOR ELECTRO-OPTIC SAMPLING AT RECORD REPETITION RATES: PRINCIPLE AND APPLICATION TO THE FIRST (TURN-BY-TURN) RECORDINGS OF THz CSR BURSTS AT SOLEIL
Abstract The microbunching instability is an ubiquitous problem in storage rings at high current density. However, the involved fast time-scales hampered the possibility to make direct real-time recordings of theses structures. When the structures occur at a cm scale, recent works at UVSOR [1], revealed that direct recording of the coherent synchrotron radiation (CSR) electric field with ultra-high speed electronics (17 ps) provides extremely precious informations on the microbunching dynamics. However, when CSR occurs at THz frequencies (and is thus out of reach of electronics), the problem remained largely open. Here we present a new opto-electronic strategy that enabled to record series of successive electric field pulses shapes with picosecond resolution (including carrier and envelope), every 12 ns, over a total duration of several milliseconds. We also present the first experimental results obtained with this method at Synchrotron SOLEIL, above the microbunching instability threshold. The method can be applied to the detection of ps electric fields in other situations where high repetition rate is also an issue
High repetition-rate electro-optic sampling: Recent studies using photonic time-stretch
Single-shot electro-optic sampling (EOS) is a powerful characterization tool for monitoring the shape of electron bunches, and coherent synchrotron radiation pulses. For reaching high acquisition rates, an efficient possibility consists to associate classic EOS systems with the so-called photonic time-stretch technique [1]. We present recent results obtained at SOLEIL and ANKA using this strategy. In particular, we show how a high sensitivity variant of photonic time stretch [2] EOS enabled to monitor the CSR pulses emitted by short electron bunches at SOLEIL [3]. We could thus confirm in a very direct way the theories predicting an interplay between two physical processes. Below a critical bunch charge, we observe a train of identical THz pulses stemming from the shortness of the electron bunches. Above this threshold, CSR emission is dominated by drifting structures appearing through spontaneous self-organization. We also consider the association of time-stretch and EOS for recording electron bunch near fields at high repetition rate. We present preliminary results obtained at ANKA, aiming at recording the electron bunch shape evolution during the microbunching instability
Progress of the LUNEX5 Project
http://accelconf.web.cern.ch/AccelConf/FEL2013/papers/wepso05.pdfInternational audienceLUNEX5 (free electron Laser Using a New accelerator for the Exploitation of X-ray radiation of 5th generation) aims at investigating the production of short, intense, and coherent pulses in the soft X-ray region. A 400 MeV superconducting linear accelerator and a laser wakefield accelerator (LWFA), will feed a single Free Electron Laser line with High order Harmonic in Gas and Echo Enable Harmonic Generation seeding. After the Conceptual Design Report (CDR), R&D has been launched on specific magnetic elements (cryo-ready 3 m long in-vacuum undulator, a variable strong permanent magnet quadrupoles), on diagnostics (Smith-Purcell, electro-optics). In recent transport studies of a LWFA based on more realistic beam parameters (1 % energy spread, 1 μm beam size and 1 mrad divergence) than the ones assumed in the CDR, a longitudinal and transverse manipulation enables to provide theoretical amplification. A test experiment is under preparation. It is noted in this context that among the French scientific community's interest in experiments at operating FELs is increasing
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