Developmental milestones of the autonomic nervous system revealed via longitudinal monitoring of fetal heart rate variability - Fig 2

<p><b>Developmental course of gMSE(3) (a, b) and skewness (c, d) in the linear mixed model.</b> (a) unclassified datasets: SoI {1–2} χ² = 11,81; p<0.001, SoI {2–3} χ² = 10.04; p = 0.0013; (b) fetal active sleep SoI {1–2} χ² = 6.7, p = 0.0096, SoI {2–3} χ² = 12.17, p<0.001; (c) unclassified datasets: SoI {1–2} χ² = 70.31, p<0.0001, SoI {2–3} χ² = 21.29, p<0.001, SoI {3–4} χ² = 3.16, p = 0.076; (d) fetal active sleep: SoI {1–2} χ² = 35.50, p<0.0001, SoI {2–3} χ² = 21.13, p<0.0001. x–Segment of Interest {< 27 WGA; 27–30 WGA; 31–35 WGA;>35 WGA}; completed weeks of GA; y–Estimator in [bit_norm] Significant (p<0.05) contrasts are marked by *, trends (p<0.10) by +. Results for ‘fetal quiescence’ are not shown because they did not reach significant levels (gMSE(3): SoI {2–3}, χ² = 3.41; p = 0.07).</p

Contrast analysis of fHRV parameters between pregnancy segments of interest.

<p>Contrast analysis of fHRV parameters between pregnancy segments of interest.</p

Developmental milestones of the autonomic nervous system revealed via longitudinal monitoring of fetal heart rate variability - Fig 1

<p><b>Developmental course of ACTAMP20 (a-c) and SDNN (d-f) in the linear mixed model.</b> (a, d) unclassified datasets, (b, e) fetal active sleep, (c, f) fetal quiescence. x–Segment of Interest {< 27 WGA; 27–30 WGA; 31–35 WGA; >35 WGA}; completed weeks of GA; y–Estimator in [ms] units. Numerical data see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200799#pone.0200799.t002" target="_blank">Table 2</a>. Significant (p<0.05) contrasts are marked by *, trends (p<0.10) by +.</p

Developmental course of pNN5 in the linear mixed model.

<p>(a) unclassified datasets, (b) fetal active sleep, (c) fetal quiescence. x–Segment of Interest {< 27 WGA; 27–30 WGA; 31–35 WGA; >35 WGA}; completed weeks of GA; y–Estimator in [%]. Numerical data see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200799#pone.0200799.t002" target="_blank">Table 2</a>. Significant (p<0.05) contrasts are marked by *, trends (p<0.10) by +.</p

Fetal state of activity.

<p>Fetal state of activity.</p