11 research outputs found
Empowering the next generation : how the young ESDPPP Community is nurturing young paediatricians and pharmacology experts
Impact of jasmonic acid on lignification in the hemp hypocotyl
info:eu-repo/semantics/publishe
S152: COMBINATORY THERAPY OF ASCIMINIB AND PONATINIB WAS EFFECTIVE IN THE TREATMENT OF BLAST PHASE CML CDX MODEL
Collaboration in neonatal and paediatric clinical pharmacology : creating a peer-based mentoring platform in a pan-European clinical trial network
Collaboration in neonatal and paediatric clinical pharmacology : involving medical students within (inter)national clinical trial networks
Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo
Early impact of severe acute respiratory syndrome coronavirus 2 on pediatric clinical research : a Pan-European and Canadian snapshot in time
Objective To capture the early effects of the coronavirus disease 2019 (COVID-19) pandemic on pediatric clinical research.
Study design Pediatric clinical research networks from 20 countries and 50 of their affiliated research sites completed two surveys over one month from early May to early June 2020. Networks liaised with their affiliated sites and contributed to the interpretation of results through pan-European group discussions. Based on first detection dates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), countries formed 1 early detecting and 1 late detecting cluster. We tested the hypothesis that this clustering influenced clinical research.
Results Research sites were first impacted by the pandemic in mid-March 2020 (March 16 +/- 10 days, the same date as lockdown initiation; P = .99). From first impact up until early June, site initiation and feasibility analysis processes were affected for >50% of the sites. Staff were redirected to COVID-19 research for 44% of the sites, and 75.5% of sites were involved in pediatric COVID-19 research (only 6.3% reported COVID-19 cases in their other pediatric trials). Mitigation strategies were used differently between the early and late detecting country clusters and between countries with and without a pediatric COVID-19 research taskforce. Positive effects include the development of teleworking capacities.
Conclusions Through this collaborative effort from pediatric research networks, we found that pediatric trials were affected and conducted with a range of unequally applied mitigations across countries during the pandemic. The global impact might be greater than captured. In a context where clinical research is increasingly multinational, this report reveals the importance of collaboration between national networks