8 research outputs found
Postinfectious Rhabdomyolysis in a 5-Year-Old Boy When to Look a Little Deeper
We report on a 5-year-old boy with recurrent severe postinfectious
rhabdomyolysis who, after systematic stepwise evaluation, was found to
have the adult form of carnitine palmityl transferase II (CPT II)
deficiency directly by blood mutation analysis. Timely diagnosis of CPT
II deficiency in this case prevented further potentially devastating
episodes of rhabdomyolysis by avoiding triggering factors. Conclusion
Although most cases of rhabdomyolysis are nonrecurrent and benign, a
metabolic myopathy, such as CPT II deficiency, should be suspected in
children with episodic muscle necrosis and paroxysmal myoglobinuria
Effect of sodium valproate monotherapy on serum uric acid concentrations in ambulatory epileptic children: A prospective long-term study
Purpose: Hyperuricemia has been shown to be related to cardiovascular
morbidity and mortality. There is controversial data about the effect of
sodium valproate (VPA) monotherapy on serum uric acid concentrations.
The purpose of this study was to investigate by a long-term, prospective
method, whether treatment with VPA monotherapy may alter serum uric acid
concentrations and liver function tests in ambulatory epileptic
children.
Material and methods: Serum uric acid concentrations were determined in
28 ambulatory epileptic children before and at 6, 12 and 24 months of
VPA monotherapy. Serum concentrations of biochemical markers of liver
and renal function, such as alanine aminotransferase (ALT), aspartate
aminotransferase (AST), lactate dehydrogenase (LDH),
gamma-glutamyltransferase (gamma-GT) and creatinine (Cr) were also
measured before and at 6, 12 and 24 months of VPA monotherapy. Serum VPA
concentrations remained within the therapeutic range (50-100 mg/L)
during the period of study.
Results: No statistically significant changes in serum Uric acid
concentrations were found at 6, 12 or 24 months of treatment. Serum ALT
concentrations were significantly increased at 6 and 12 months of
treatment, AST concentrations at 6 and 12 months of treatment and LDH
concentrations at 12 months of treatment.
Conclusions: VPA monotherapy does not have a significant effect on serum
uric acid concentrations in ambulatory epileptic children. Further
studies are needed to definitively address whether it would be useful
for physicians to routinely check for elevated serum uric acid levels in
children treated with VPA. (C) 2006 European Paediatric Neurology
Society. Published by Elsevier Ltd. All rights reserved