Idiopathic Synovial Osteochondromatosis of the Hip: Radiographic and MR Appearances in 15 Patients

[Objective] To evaluate the radiographic and MR appearance of idiopathic synovial osteochondromatosis of the hip. [Materials and Methods]Radiographs and MR images of 15 patients with idiopathic synovial osteochondromatosis of the hip were assessed. The former were analysed in terms of the presence of 1) juxta-articular calcified and/ or ossified bodies, 2) osteophytes, 3) bone erosion, 4) juxta-articular osteopenia, and 5) joint space narrowing, while for the latter, analysis focused on 1) the configuration of intra-articular bodies, 2) bone erosion, 3) synovial thickening, 4) conglomeration of intra-articular bodies, and 5) extra-articular extension. [Results]At hip radiography, juxta-articular calcified and/ or ossified bodies were seen in 12 of the 15 patients (80%), bone erosion in eight (53%), osteophytes in seven (47%), juxta-articular osteopenia in five (33%) and joint space narrowing in five (33%). In eight patients (53%), MR imaging depicted intra-articular bodies of focal low signal intensity at all pulse sequences, and areas of iso-intensity at T1WI and hyperintensity at T2WI. In three (20%), intra-articular bodies of focal low signal intensity and areas of hyperintensity at all pulse sequences were observed, with areas of iso-intensity at T1WI and hyperintensity at T2WI, while in four (27%), intra-articular bodies of only focal low signal intensity at all pulse sequences were apparent. Synovial thickening was present in 13 patients (87%), bone erosion in 11 (73%), conglomeration of the intra-articular bodies in 11 (73%), and an extra-articular herniation sac in six (40%). [Conclusion]The most common radiographic finding of synovial osteochondromatosis of the hip was the presence of juxta-articular calcified and/ or ossified bodies. MR imaging depicted intra-articular bodies of focal low signal intensity at all pulse sequences, with areas of iso-intensity at T1WI and hyperintensity at T2WI. In addition, the presence of an extra-articular herniation sac was not uncommon.ope

In vitro Antibacterial and Morphological Effects of the Urushiol Component of the Sap of the Korean lacquer tree (Rhus vernicifera Stokes) on Helicobacter pylori

Eradication regimens for Helicobacter pylori infection have some side effects, compliance problems, relapses, and antibiotic resistance. Therefore, alternative anti-H. pylori or supportive antimicrobial agents with fewer disadvantages are necessary for the treatment of H. pylori. We investigated the pH-(5.0, 6.0, 7.0, 8.0, 9.0, and 10.0) and concentration (0.032, 0.064, 0.128, 0.256, 0.514, and 1.024 mg/mL)-dependent antibacterial activity of crude urushiol extract from the sap of the Korean lacquer tree (Rhus vernicifera Stokes) against 3 strains (NCTC11637, 69, and 219) of H. pylori by the agar dilution method. In addition, the serial (before incubation, 3, 6, and 10 min after incubation) morphological effects of urushiol on H. pylori were examined by electron microscopy. All strains survived only within pH 6.0-9.0. The minimal inhibitory concentrations of the extract against strains ranged from 0.064 mg/mL to 0.256 mg/mL. Urushiol caused mainly separation of the membrane, vacuolization, and lysis of H. pylori. Interestingly, these changes were observed within 10 min following incubation with the 1×minimal inhibitory concentrations of urushiol. The results of this work suggest that urushiol has potential as a rapid therapeutic against H. pylori infection by disrupting the bacterial cell membrane

Granular Cell Tumors of the Abdominal Wall

Granular cell tumors (GCT) are found in virtually any body site, including the tongue, skin, subcutaneous tissue, breast, rectum and vulva. However, they are rarely seen in the abdominal wall. We report here on a rare case of GCT in the rectus muscle of the abdominal wall. A 44-year-old woman presented with a non-tender, hard mass in the right lower abdominal wall. Upon microscopic examination, the tumor was found to comprise of large polygonal cells with an abundant eosinophilic granular cytoplasm and round to oval nuclei. Upon immunohistochemical staining, the large cells showed S-100 and CD68 positive granular aggregates in the cytoplasm. Many lysosomes of variable size were observed in the cytoplasm

Fimasartan versus perindopril with and without diuretics in the treatment of elderly patients with essential hypertension (Fimasartan in the Senior Subjects (FITNESS)): study protocol for a randomized controlled trial

Background Hypertension is an important risk factor for cardiovascular disease, even in the elderly. Fimasartan is a new non-peptide angiotensin II receptor blocker with a selective type I receptor blocking effect. The objective of this study is to confirm the safety and the non-inferiority of the blood pressure–lowering effect of fimasartan compared with those of perindopril, which has been proven safe and effective in elderly patients with hypertension. Methods This is a randomized, double-blind, active-controlled, two-parallel group, optional-titration, multicenter, phase 3 study comparing the efficacy and safety of fimasartan and perindopril arginine. The study population consists of individuals 70 years old or older with essential hypertension. The primary outcome will be a change in sitting systolic blood pressure from baseline after the administration of the investigational product for 8 weeks. The secondary outcomes will be a change in sitting diastolic blood pressure from baseline and changes in sitting systolic blood pressure and diastolic blood pressure from baseline after the administration of the investigational product for 4, 16, and 24 weeks. The sample size will be 119 subjects for each group to confer enough power to test for the primary outcome. Discussion Research to confirm the efficacy and safety of a new medicine compared with those of previously proven anti-hypertensive drugs is beneficial to guide physicians in the selection of therapeutic agents. If it is confirmed that the new drug is not inferior to the existing drug, the drug will be considered as an option in the treatment of hypertension in elderly patients. Trial registration ClinicalTrials.gov Identifier: NCT03246555, registered on July 25, 2017.The study is funded by Boryung Pharmaceutical Co., Ltd. The company was involved in all stages of the study conduct and design. Boryung also took responsibility for all costs associated with the development and publishing of the manuscript

Consumer Acceptance Analysis of the Home Energy Management System

The purpose of this paper is to study consumer acceptance of the Home Energy Management System, which is the next generation electronic management system that the Korean government plans to implement in households. The Home Energy Management System is a critical device in maximizing the efficiency of electric energy consumption for each household by using a smart grid. Because it can visualize real-time price information on the electricity, households can easily monitor and control the amount of electricity consumption. With this feature, the Home Energy Management System can contribute to consumers’ total energy savings. This is a major reason why the Korean government wishes to implement it nationwide. Since the Home Energy Management System is a product that applies new technology that has not yet been directly encountered by consumers, there may be a difference in the level of public perception of the Home Energy Management System. Therefore, the impact of consumers’ awareness of the Home Energy Management System on their intention to use is important. To do this, the Technology Acceptance Model is utilized in this study. Traditional research on the Technology Acceptance Model includes awareness of usefulness and ease of use as well as intention to use. In contrast, in this research, an extended Technology Acceptance Model with four additional factors—economic benefit, social contribution, environmental responsibility, and innovativeness—that may affect the consumer’s awareness of usefulness and ease of use, is proposed. To collect the data, the survey was conducted with 287 respondents. As a result, the proposed model proved to be suitable in explaining the intention to use with a 70.3% explanation power. It is found that economic benefit (0.231) and innovativeness (0.259) impact on usefulness of the Home Energy Management System. Moreover, usefulness (0.551) has a bigger effect on intention to use than ease of use (0.338) does. Based on this, it is desirable for the Korean government to pursue a public relations strategy that emphasizes the economic benefits, social contributions, and environmental responsibility that will be gained when introducing the Home Energy Management System. It is effective to focus on consumers who are inclined to accept innovation. In addition, more effective results can be obtained by referring to the usefulness of the Home Energy Management System rather than referring to ease of use

The effect of Hallyu on tourism in Korea

The purposes of the study are to estimate inbound tourism demand and to analyze the effect of the Korean Wave and Economic indicators on it. For these purposes, we examined the influence of Korean Wave, GDP, CPI and exchange rate on inbound tourism demand for foreign tourists from the USA, China, Japan and Hong Kong to Korea. In order to measure the Korean wave, the export amount of Hallyu related contents exported to each of the four countries is used. GDP means the GDP of each of the four countries. However, the CPI and the exchange rate are relative to Korea. Penal data on tourism demand, Korean Wave, and Economic indicators from 1997 to 2014 are collected for analysis. Through the various tests for panel analysis model selection, the best fit model proved to be a random effect model. As a result, Korean Wave, GDP, and exchange rate have a statistically significant impact on tourism demand. Therefore, it can be seen that the Korean Wave is one of the important factors for attracting foreign tourists to Korea in four countries. Also, the results show that overseas tourism increases when the economic income of the country is high and the exchange rate is favorable. However, CPI does not appear to have a statistically significant impact on tourism demand. This indicates that tourists are not overly concerned about the cost of the travel country when planning a trip