Enhancement of rainfall and runoff upstream from irrigation location in a climate model of West Africa

This study investigates the impact of potential medium-scale irrigation (about 60,000 km²) on the climate of West Africa using the MIT Regional Climate Model. We find that irrigation at this scale induces an atmospheric response similar to that of large-scale irrigation (about 400,000km²) which was considered in our previous theoretical study. While the volume of water needed for large-scale irrigation is about 230–270 km³, the medium-scale irrigation requires about 50 km³, and the annual flow of the Niger river in the relevant section is about 70 km³. The remote response of rainfall distribution to local irrigation exhibits a significant sensitivity to the latitudinal location of irrigation. The nature of this response is such that irrigation from the Niger River around latitude 18°N induces significant increase in rainfall of order 100% in the upstream sources of the Niger River and results in significant increase in runoff of order 50%. This additional runoff can potentially be collected by the river network and delivered back toward the irrigation area. By selecting the location of irrigation carefully, the positive impacts of irrigation on rainfall distribution can be maximized. The approach of using a regional climate model to investigate the impact of location and size of irrigation schemes, explored in this study, may be the first step in incorporating land-atmosphere interactions in the design of location and size of irrigation projects. However, this theoretical approach is still in early stages of development and further research is needed before any practical application in water resources planning

Numerical simulation of the heavy rainfall caused by a convection band over Korea: a case study on the comparison of WRF and CReSS

This study investigates the capability of two numerical models, namely the Weather Research and Forecasting (WRF) and Cloud Resolving Storm Simulator (CReSS), to simulate the heavy rainfall that occurred on September 21, 2010 in the middle of the Korean peninsula. This event was considered part of the typical rainfall caused by intense quasi-stationary convection band, leading to a large accumulated rainfall amount within a narrow area. To investigate the relevant characteristics of this heavy rainfall and the feasibility of the numerical models to simulate them, the experiments using both numerical models were designed with a focus on Korea with a horizontal grid spacing of 2 km. The initial and later boundary conditions were interpolated using the output of the mesoscale model of Japan Meteorological Agency and integration spanned the 24-h period from 2100 UTC on September 20, 2010 when the rainfall started in the Yellow Sea. Generally, the spatial distribution and temporal evolution of the rainfall simulated by CReSS are closer than those of the WRF to the in situ observations (655 stations). The WRF simulation reveals the deficiency in capturing the unusual stagnant behavior of this event. The spatial and vertical patterns of reflectivity are consistent with the rainfall pattern, supporting that strong reflectivity coincides with the convective activity that accompanies excessive rainfall. The thermodynamic structure is the main driver of the different behavior between both simulations. The higher equivalent potential temperature, deep moist absolutely unstable layer and strong veering wind shear seen in the CReSS simulation play a role in the development of a favorable environment for inducing convection.National Institute of Meteorological Research (Korea) (Grant (NIMR-2012-B-7))Korea. Meteorological Administratio

Higher Hydroclimatic Intensity with Global Warming

Abstract Because of their dependence on water, natural and human systems are highly sensitive to changes in the hydrologic cycle. The authors introduce a new measure of hydroclimatic intensity (HY-INT), which integrates metrics of precipitation intensity and dry spell length, viewing the response of these two metrics to global warming as deeply interconnected. Using a suite of global and regional climate model experiments, it is found that increasing HY-INT is a consistent and ubiquitous signature of twenty-first-century, greenhouse gas–induced global warming. Depending on the region, the increase in HY-INT is due to an increase in precipitation intensity, dry spell length, or both. Late twentieth-century observations also exhibit dominant positive HY-INT trends, providing a hydroclimatic signature of late twentieth-century warming. The authors find that increasing HY-INT is physically consistent with the response of both precipitation intensity and dry spell length to global warming. Precipitation intensity increases because of increased atmospheric water holding capacity. However, increases in mean precipitation are tied to increases in surface evaporation rates, which are lower than for atmospheric moisture. This leads to a reduction in the number of wet days and an increase in dry spell length. This analysis identifies increasing hydroclimatic intensity as a robust integrated response to global warming, implying increasing risks for systems that are sensitive to wet and dry extremes and providing a potential target for detection and attribution of hydroclimatic changes

The Impacts of Role Overload and Role Conflict on Physicians\u27 Technology Adoption

Technology adoption is an important solution for physicians to increase work efficiency, and thus deal with role conflict among their multiple job roles. Prior studies have not investigated how multiple job roles and role conflict influence physicians’ technology adoption intentions. Based on role strain theory and role identity theory, we present a model of physicians’ technology adoption intentions to support their primary (clinical care) versus secondary (teaching or research) job roles. We test the model using surveys with 156 physicians at nine medical schools in Korea. The results of our data analysis largely support our hypotheses. Role overload in each of their job roles increases role conflict between any pair of associated roles. Furthermore, role conflict between a physician’s primary and secondary role is affected more by role overload in the secondary role than by overload in the primary role. Moreover, the impact of role conflict on technology adoption intentions is also influenced by the hierarchical relationship between two roles. This study contributes to technology adoption research by demonstrating how physicians’ job characteristics affect technology adoption

Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo

BACKGROUND: Drug transporters play important roles in the absorption, distribution, and elimination of drugs and thereby, modulate drug efficacy and toxicity. With a growing use of poly pharmacy, concurrent administration of herbal extracts that modulate transporter activities with drugs can cause serious adverse reactions. Therefore, prediction and evaluation of drug-drug interaction potential is important in the clinic and in the drug development process. DA-9801, comprising a mixed extract of Dioscoreae rhizoma and Dioscorea nipponica Makino, is a new standardized extract currently being evaluated for diabetic peripheral neuropathy in a phase II clinical study. METHOD: The inhibitory effects of DA-9801 on the transport functions of organic cation transporter (OCT)1, OCT2, organic anion transporter (OAT)1, OAT3, organic anion transporting polypeptide (OATP)1B1, OATP1B3, P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) were investigated in HEK293 or LLC-PK1 cells. The effects of DA-9801 on the pharmacokinetics of relevant substrate drugs of these transporters were also examined in vivo in rats. RESULTS: DA-9801 inhibited the in vitro transport activities of OCT1, OCT2, OAT3, and OATP1B1, with IC(50) values of 106, 174, 48.1, and 273 μg/mL, respectively, while the other transporters were not inhibited by 300 μg/mL DA-9801. To investigate whether this inhibitory effect of DA-9801 on OCT1, OCT2, and OAT3 could change the pharmacokinetics of their substrates in vivo, we measured the pharmacokinetics of cimetidine, a substrate for OCT1, OCT2, and OAT3, and of furosemide, a substrate for OAT1 and OAT3, by co-administration of DA-9801 at a single oral dose of 1,000 mg/kg. Pre-dose of DA-9801 5 min or 2 h prior to cimetidine administration decreased the C(max) of cimetidine in rats. However, DA-9801 did not affect the elimination parameters such as half-life, clearance, or amount excreted in the urine, suggesting that it did not inhibit elimination process of cimetidine, which is governed by OCT1, OCT2, and OAT3. Moreover, DA-9801 did not affect the pharmacokinetic characteristics of furosemide, as evidenced by its unchanged pharmacokinetic parameters. CONCLUSION: Inhibitory effects of DA-9801 on OCT1, OCT2, and OAT3 observed in vitro may not necessarily translate into in vivo herb-drug interactions in rats even at its maximum effective dose

Correction to: Emergence of robust anthropogenic increase of heat stress-related variables projected from CORDEX-CORE climate simulations

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A Pilot Study for the Neuroprotective Effect of Gongjin-dan on Transient Middle Cerebral Artery Occlusion-Induced Ischemic Rat Brain

In this study, we investigated whether gongjin-dan improves functional recovery and has neuroprotective effects on reducing the infarct volume after transient middle cerebral artery occlusion (MCAo). Infarct volume was measured using TTC staining and glucose utilization by F-18 FDG PET. Functional improvement was evaluated with the Rota-rod, treadmill, Garcia score test, and adhesive removal test. At 14 days after MCAo, neuronal cell survival, astrocytes expansion, and apoptosis were assessed by immunohistofluorescence staining in the peri-infarct region. Also, the expression of neurotrophic factors and inflammatory cytokines such as VEGF, BDNF, Cox-2, TNF-α, IL-1β, and IL-1α was measured in ischemic hemisphere regions. The gongjin-dan-treated group showed both reduced infarct volume and increased glucose utilization. Behavior tests demonstrated a significant improvement compared to the control. Also in the gongjin-dan treated group, NeuN-positive cells were increased and number of astrocytes, microglia, and apoptotic cells was significantly decreased compared with the control group in the ischemic peri-infarct area. Furthermore, the expression of VEGF and BDNF was increased and level of Cox-2, TNF-α, IL-1β, and IL-1α was decreased. These results suggest that gongjin-dan may improve functional outcome through the rapid restoration of metabolism and can be considered as a potential neuroprotective agent

Robust late twenty-first century shift in the regional monsoons in RegCM-CORDEX simulations

AbstractWe use an unprecedented ensemble of regional climate model (RCM) projections over seven regional CORDEX domains to provide, for the first time, an RCM-based global view of monsoon changes at various levels of increased greenhouse gas (GHG) forcing. All regional simulations are conducted using RegCM4 at a 25 km horizontal grid spacing using lateral and lower boundary forcing from three General Circulation Models (GCMs), which are part of the fifth phase of the Coupled Model Inter-comparison Project (CMIP5). Each simulation covers the period from 1970 through 2100 under two Representative Concentration Pathways (RCP2.6 and RCP8.5). Regional climate simulations exhibit high fidelity in capturing key characteristics of precipitation and atmospheric dynamics across monsoon regions in the historical period. In the future period, regional monsoons exhibit a spatially robust delay in the monsoon onset, an increase in seasonality, and a reduction in the rainy season length at higher levels of radiative forcing. All regions with substantial delays in the monsoon onset exhibit a decrease in pre-monsoon precipitation, indicating a strong connection between pre-monsoon drying and a shift in the monsoon onset. The weakening of latent heat driven atmospheric warming during the pre-monsoon period delays the overturning of atmospheric subsidence in the monsoon regions, which defers their transitioning into deep convective states. Monsoon changes under the RCP2.6 scenario are mostly within the baseline variability

The Spectrum of Benign Esophageal Lesions: Imaging Findings

Benign esophageal lesions occur in various diseases. Barium studies are useful for the evaluation of mucosal surface lesions but provide little information about the extramucosal extent of disease. Computed tomography and magnetic resonance imaging, on the other hand, permit the assessment of wall thickness, mediastinal involvement, adjacent lymphadenopathy, and distant spread. In diseases such as fibrovascular polyps, duplication cysts, scleroderma, trauma, caustic esophagitis, hiatal hernia, esophageal diverticulum, achalasia, and paraesophageal varices, the findings of imaging studies are specific, obviating the need for further invasive diagnostic work-up. The advent of helical computed tomography and its volume data set allows the acquisition of multiplanar images, and magnetic resonance imaging is useful both for this and for tissue characterization. Thus, multiplanar cross-sectional imaging further extends the role of imaging modalities to the evaluation of benign esophageal lesions. Through an awareness of the multiplanar cross-sectional appearances of various benign esophageal lesions, the radiologist can play an important role in the detection, diagnosis, further diagnostic planning, and treatment of the diseases in which they occur