Hemoprotozoa of domestic animals in France: Prevalence and molecular characterization

Very limited information is available on epizootiology of haematozoan infections in French domestic animals. In an attempt to address this issue, prevalence of piroplasmida was studied in carnivores and ruminants, whereas prevalence of Hepatozoon spp. was only investigated in carnivores. In total, 383 animals were included in the survey (namely 116 cats, 108 dogs, 91 sheep and 68 cows). Parasite diagnosis was carried out using molecular methods such as PCR and sequencing of the 18S rRNA gene. In addition, ruminant samples were analyzed with the reverse line blotting technique (RLB). Results of RLB and PCR plus sequencing were in total agreement. In carnivores, haematozoan prevalence was close to 1%. Two cats were infected by H. canis (1.7% prevalence) and one of them was co-infected by Cytauxzoon sp. (0.8%). This represents the first finding of both pathogens in French cats. One dog was infected by H. canis (0.9%) and another by Babesia canis vogeli (0.9%). In ruminants, haematozoan prevalence (piroplasmida) was significantly higher than in carnivores (4.8% in sheep and 8.8% in cow). Theileria ovis was found in 1 sheep, Theileria sp. in 2 sheep, Theileria buffeli in 5 cows and B. major in 1 cow. Evidence presented in this contribution indicates that haematic protozoa are not widely distributed in domestic mammal populations of France

Phase I and pharmacokinetic study of XR11576, an oral topoisomerase I and II inhibitor, administered on days 1–5 of a 3-weekly cycle in patients with advanced solid tumours

XR11576 is an oral topoisomerase I and II inhibitor. The objectives of this phase I study were to assess the dose-limiting toxicities (DLTs), to determine the maximum tolerated dose (MTD) and to describe the pharmacokinetics (PKs) of XR11576 when administered orally on days 1-5 every 3 weeks to patients with advanced solid tumours. Patients were treated with escalating doses of XR11576 at doses ranging from 30

Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review

Abstract BACKGROUND: The current article is a systematic review concerning the efficacy and safety of aripiprazole in the treatment of bipolar disorder. METHODS: A systematic Medline and repositories search concerning the usefulness of aripiprazole in bipolar disorder was performed, with the combination of the words 'aripiprazole' and 'bipolar'. RESULTS: The search returned 184 articles and was last updated on 15 April 2009. An additional search included repositories of clinical trials and previous systematic reviews specifically in order to trace unpublished trials. There were seven placebo-controlled randomised controlled trials (RCTs), six with comparator studies and one with add-on studies. They assessed the usefulness of aripiprazole in acute mania, acute bipolar depression and during the maintenance phase in comparison to placebo, lithium or haloperidol. CONCLUSION: Aripiprazole appears effective for the treatment and prophylaxis against mania. The data on bipolar depression are so far negative, however there is a need for further study at lower dosages. The most frequent adverse effects are extrapyramidal signs and symptoms, especially akathisia, without any significant weight gain, hyperprolactinaemia or laboratory test changes

Impact of volatile phenols and their precursors on wine quality and control measures of Brettanomyces/Dekkera yeasts

Volatile phenols are aromatic compounds and one of the key molecules responsible for olfactory defects in wine. The yeast genus Brettanomyces is the only major microorganism that has the ability to covert hydroxycinnamic acids into important levels of these compounds, especially 4-ethylphenol and 4-ethylguaiacol, in red wine. When 4-ethylphenols reach concentrations greater than the sensory threshold, all wine’s organoleptic characteristics might be influenced or damaged. The aim of this literature review is to provide a better understanding of the physicochemical, biochemical, and metabolic factors that are related to the levels of p-coumaric acid and volatile phenols in wine. Then, this work summarizes the different methods used for controlling the presence of Brettanomyces in wine and the production of ethylphenols

Développement d'un robot autonome pour l'acquisition active et le traitement d'images

Ce projet se situe dans la continuité des travaux menés en 2016, consistant à développer et à mettre en application un système robotisé destiné à acquérir des données images et à les traiter, dans des parcelles de betteraves sucrières de façon autonome. Deux systèmes robotisés ont été utilisés: un robot mobile et un bras manipulateur à 6 DDL, pour travailler respectivement sur des stades de levée peu avancés et très avancés

Génération d'harmoniques dans un système double faisceau en la présence d'un champ magnétique

The h. f. oscillations generated by a symmetric system of two counter-streaming beams in the présence of a magnetic field, have been studied. They consist of a spectrum of harmonies of half the electron gyromagnetic frequency and a spectrum related to the electron transit time.Les oscillations HF engendrées dans un système symétrique de deux faisceaux opposés en présence d'un champ magnétique ont été étudiées. Le spectre se compose de raies harmoniques de la demi-fréquence gyromagnétique électronique et de raies liées au temps de transit des électrons

Étude de faisceaux d'ions en présence d'un champ magnétique uniforme

The mechanisms of interaction of a neutralized beam of ions and also of two symmetric neutralized ion beams flowing parallel to a magnetic field, are described. The dispersion relation for obliquely propagating electrostatic waves is considered in relation to the following topics.1. A beam of cold ions neutralized by cold electrons at rest. — 2. Influence of a cold plasma. — 3. Role of the electron term. — 4. Expression of the relations previously obtained, allowing for a transverse thermal velocity. — 5. The case of two symmetric ion beams, neutralized by electrons at rest. We present results obtained in the EOS experiment, which was set up to study these interactions for the following cases : a) one beam ; b) two symmetric beams.Les mécanismes d'interaction d'un faisceau d'ions neutralisé et de deux faisceaux d'ions, symétriques, neutralisés, dirigés parallèlement à un champ magnétique sont discutés. Pour cela nous considérons la relation de dispersion des ondes électrostatiques à propagation oblique dans les situations suivantes : 1) Un faisceau d'ions froids neutralisé par un gaz d'électrons froids au repos. - 2) Influence d'un plasma froid. — 3) Rôle du terme électronique. — 4) Expression des relations précédemment obtenues en tenant compte d'une vitesse thermique perpendiculaire. — 5) Cas de deux faisceaux d'ions symétriques, neutralisés par des électrons au repos. Nous présentons des résultats obtenus dans l'expérience EOS construite pour l'étude de ces interactions dans les deux situations suivantes : a) un faisceau ; b) deux faisceaux symétriques