Governments under influence: Country interactions in discretionary fiscal policy

We investigate the interactions between countries of the discretionary component of national fiscal policies (i.e. the cyclically- and interest-adjusted part of fiscal policy), therefore observing and investigating the part of public spending and tax receipts on which governments keep full discretion. Our sample covers 18 OECD countries, during the 1974-2008 period. First, we build a measure of such discretionary fiscal policy, considered as the residual component of a VAR model, and compute the measure for the full sample. Drawing on this new dataset, the second step provides estimates of discretionary fiscal policy interactions between countries of the sample. Our results highlight the existence of interactions between neighboring countries' public decisions, where neighborhood is defined by economic leadership as well as geography. We also find evidence of an opportunistic behavior of OECD countries' governments for the discretionary public spending. Finally, the disciplining device of the European Union fiscal framework is shown to be ineffective.Fiscal policy; discretion; interactions; VAR; spatial econometrics

Impact of sub-inhibitory antibiotics on fibronectin-mediated host cell adhesion and invasion by Staphylococcus aureus

<p>Abstract</p> <p>Background</p> <p><it>Staphylococcus aureus </it>is a well-armed pathogen prevalent in severe infections such as endocarditis and osteomyelitis. Fibronectin-binding proteins A and B, encoded by <it>fnb</it>A/B, are major pathogenesis determinants in these infections through their involvement in <it>S. aureus </it>adhesion to and invasion of host cells. Sub-minimum inhibitory concentrations (sub-MICs) of antibiotics, frequently occurring <it>in vivo </it>because of impaired drug diffusion at the infection site, can alter <it>S. aureus </it>phenotype. We therefore investigated their impact on <it>S. aureus </it>fibronectin-mediated adhesiveness and invasiveness.</p> <p>Methods</p> <p>After <it>in vitro </it>challenge of <it>S. aureus </it>8325-4 and clinical isolates with sub-MICs of major anti-staphylococcal agents, we explored <it>fnb</it>A/B transcription levels, bacterial adhesiveness to immobilised human fibronectin and human osteoblasts in culture, and bacterial invasion of human osteoblasts.</p> <p>Results</p> <p>Oxacillin, moxifloxacin and linezolid led to the development of a hyper-adhesive phenotype in the fibronectin adhesion assay that was consistent with an increase in <it>fnb</it>A/B transcription. Conversely, rifampin treatment decreased fibronectin binding in all strains tested without affecting <it>fnb</it>A/B transcription. Gentamicin and vancomycin had no impact on fibronectin binding or <it>fnb</it>A/B transcription levels. Only oxacillin-treated <it>S. aureus </it>displayed a significantly increased adhesion to cultured osteoblasts, but its invasiveness did not differ from that of untreated controls.</p> <p>Conclusion</p> <p>Our findings demonstrate that several antibiotics at sub-MICs modulate fibronectin binding in <it>S. aureus </it>in a drug-specific fashion. However, hyper- and hypo- adhesive phenotypes observed in controlled <it>in vitro </it>conditions were not fully confirmed in whole cell infection assays. The relevance of adhesion modulation during <it>in vivo </it>infections is thus still uncertain and requires further investigations.</p

Identification of equivalent topography in an open channel flow using Lagrangian data assimilation

International audienceWe present a Lagrangian data assimilation experiment in an open channel flow above a broad-crested weir. The observations consist of trajectories of particles transported by the flow and extracted from a video film, in addition to classical water level measurements. However, the presence of vertical recirculations on both sides of the weir actually conducts to the identification of an equivalent topography corresponding to the lower limit of a surface jet. In addition, results on the identification of the Manning coefficient may allow to detect the presence of bottom recirculations

Methicillin-Resistant Staphylococcus capitis with Reduced Vancomycin Susceptibility Causes Late-Onset Sepsis in Intensive Care Neonates

isolated from the blood of NICU infants and compared these data to adult patients. element, and constantly showed either vancomycin resistance (37.5%) or heteroresistance (62.5%). Conversely, the isolates that were collected outside of the NICU were genetically diverse and displayed much lower rates of vancomycin resistance and heteroresistance (7.7% and 23.1%, respectively). strains has spread into several French NICUs. These isolates exhibit reduced susceptibility to vancomycin, which is the most widely used antimicrobial agent in the NICU setting

Community-associated Methicillin-resistant Staphylococcus aureus, Singapore

10.3201/eid1102.040782Emerging Infectious Diseases112341-34

Teaching Real-Time Scheduling Analysis with Cheddar

National audienceThis article is a presentation of the Cheddar toolset.Cheddar is a GPL open-source scheduling analysis tool.It has been designed and distributed to allow students to understand the main concepts of the real-time scheduling theory.The tool is built around a simplified ADL (Architecture Description Language)devoted to real-time scheduling theory. Students can directly build their real-time systems models with this ADL andits associated editor, however, it is expected that they use modeling tools to illustrate how scheduling analysis fits in an engineering process.In this article, we introduce the Cheddar ADL and the scheduling analysis features of Cheddar. We alsopresent how Cheddar is implemented and how it can be adapted to specific requirements.Two examples of use of Cheddar are then described.Finally, in the annex of this article, teachers may find a sample of hand-outs that may be used to illustrate real-time scheduling theory with their students