Mise en évidence et caractérisation de nouveaux facteurs de communication intercellulaire (les microparticules endothéliales cornéennes. Implications potentielles en greffe de cornée)

BESANCON-BU Médecine pharmacie (250562102) / SudocSudocFranceF

Choix d'une technique de typage des dysglobulinémies monoclonales adaptée à l'activité du laboratoire d'immunologie de l'établissement français du sang Bourgogne-Franche-Comté, site de Besançon

BESANCON-BU Médecine pharmacie (250562102) / SudocSudocFranceF

MISE AU POINT D'UNE METHODE DE DOSAGE DES IMMUNOGLOBULINES DANS LES SECRETIONS MUQUEUSES (INTERET POUR L'EXPLORATION DE L'IMMUNITE DU TRACTUS GENITAL FEMININ (DES PHARMACIE SPECIALISEE))

BESANCON-BU Médecine pharmacie (250562102) / SudocSudocFranceF

Inhiber l'angiogenèse dans la dégénrescence maculaire liée à l'âge exdudative (intérêt des nouvelles molécules anti-vegf)

BESANCON-BU Médecine pharmacie (250562102) / SudocSudocFranceF

Risque de pandémie grippale en 2007 (rôle du pharmacien d'officine)

BESANCON-BU Médecine pharmacie (250562102) / SudocSudocFranceF

Intérêt et limites du dosage de la troponine en cardiologie (le test AccuTnI de Beckman Coulter)

BESANCON-BU Médecine pharmacie (250562102) / SudocSudocFranceF

Rôle des microparticules endothéliales sur l'activation des cellules dendritiques et applications potentielles dans les pathologies inflammatoires

BESANCON-BU Médecine pharmacie (250562102) / SudocSudocFranceF

Triazinic herbicide determination by gas chromatography-mass spectrometry in breast milk.

International audienceA solid-phase extraction procedure using a graphitized carbon black cartridge for extraction and cleaning of a series of five triazines (atrazine, deethylatrazine, deisopropylatrazine, ametryne and prometryne) from breast milk samples was developed. Using a chemometric methodology, the optimisation of both the analysis time and the triazinic herbicide separation by gas chromatography-mass spectrometry (GC-MS) was then carried out with only 18 experiments. Detection and quantification limits for 1ml breast milk sample were, respectively, 0.3 and 1 ppb for each studied compound. The variation coefficients were less than 5% over the concentration range from 1 to 100 ppb. The accuracy was between 98.63 and 104.62% for each triazinic herbicide. The recovery was between 58.64 and 63.22% for the concentration range from 1 to 100 ppb for each triazinic herbicide. The assay was successfully applied to the analysis of several breast milk samples

Phosphatidylserine-expressing cell by-products in transfusion: A pro-inflammatory or an anti-inflammatory effect?

International audienceLabile blood products contain phosphatidylserine-expressing cell dusts, including apoptotic cells and microparticles. These cell by-products are produced during blood product process or storage and derived from the cells of interest that exert a therapeutic effect (red blood cells or platelets). Alternatively, phosphatidylserine-expressing cell dusts may also derived from contaminating cells, such as leukocytes, or may be already present in plasma, such as platelet-derived microparticles. These cell by-products present in labile blood products can be responsible for transfusion-induced immunomodulation leading to either transfusion-related acute lung injury (TRALI) or increased occurrence of post-transfusion infections or cancer relapse. In this review, we report data from the literature and our laboratory dealing with interactions between antigen-presenting cells and phosphatidylserine-expressing cell dusts, including apoptotic leukocytes and blood cell-derived microparticles. Then, we discuss how these phosphatidylserine-expressing cell by-products may influence transfusion