Urban regeneration: thirty years of change on Plymouth’s waterfront

Waterfront revitalisation has become one of the main areas of concentration and activity in urban regeneration as former port, military and resort sites seek new and appropriate uses. Various regeneration approaches have been implemented over the years, with most involving central-government funding, but with different levels of partnership with the private sector and/or the local community. This paper explores in detail the transformation of the waterfront in the English city of Plymouth from its former functions as a naval port and dockyard, with both military and commercial port activities, to its predominantly post-industrial focus on residential, leisure, tourism, and heritage uses. It is a process that has gained momentum over the last thirty years and is now central to the city’s vision of its future

Understanding the planning challenges of brownfield development in coastal urban areas of England

Available in Pearl https://pearl.plymouth.ac.uk/handle/10026.1/4528 deposited 20/4/1

The challenge of urban design in securing post-event legacies of Olympic Parks

Olympic Parks demand a very distinctive built environment in order to function for their primary purpose, namely to host major sporting competitions. These spaces, however, require substantial reconfiguration in the post-event mode to ensure viable, mixed use and liveable places. This paper evaluates the challenges of transforming Olympic Parks, using evidence from four past hosts: Munich (1972), Sydney (2000), London (2012) and Rio de Janeiro (2016). The discussion raises questions about retaining the ceremonial focus of the Olympic Park and whether a more decentralised model might make the associated urban design and planning legacies more deliverable for future host cities

A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A

This is the author accepted manuscript. The final version is available from American Association for the Advancement of Science via the DOI in this record.The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1