Synthèse et Etude pharmacologique de la 4-phényl-l, 5-benzodiazépin-2-one et ses dérivés

L'étude de l’activité pharmacologique de la 4-phényl-1,5-benzodiazépin-2-one, 4-phényl-1,3,4,5-tétrahydro-1,5-benzodiazépin-2-one, 4-phényl-1,5-benzodiazépin-2-thiole synthétisées dans notre Laboratoire montrent que ces produits ne sont pas toxiques aux doses thérapeutiques et qu'ils sont doués d'effets sédatif, myorelaxant, anxiolytique mais, ne présentent pas d’effet hypnotique, ni cataleptique. Cependant, ces trois produits de synthèse potentialisent à des degrés différents l'effet hypnotique du Nesdonal.Mots clés: 1,5-benzodiazépine, synthèse, toxicité aiguë, activité psychotrope.The study of the pharmacological activity of the 4-phényl-1,5-benzodiazépin-2-one, 4-phényl-1,3,4,5-tétrahydro-1,5-benzodiazépin-2-one, 4-phényl-1,5-benzodiazépin-2-thiol synthesized in our laboratory showed that these products are not toxic at therapeutic doses and possess sedative, muscle relaxant, anxiolytic effects, but do not present any hypnotic, or catalepsy effect. However, these three products potentiate synthesis to different degrees of the hypnotic effect Nesdonal

Inhibitive effect of some 1,5-benzodiazepin 2-one derivatives on the corrosion of iron in 1M HCl

The effect of some 1,5-benzodiazepin 2-one derivatives on the corrosion behaviour of iron in 1M HCl has been investigated by gravimetric and electrochemical polarization methods. Both techniques gave the same order of inhibition efficiencies. Polarization data indicate that all of the compounds tested act as mixed-type inhibitors, without changing the mechanism of the cathodic hydrogen evolution reaction. The inhibition efficiency of the compounds tested has been found to decrease as follows: 7-methyl 4-phenyl 1,5-benzodiazepin 2-one > 4-phenyl 1,5-benzodiazepin 2-one > 3,7-dimethyl 1,5-benzodiazepin 2-one. These compounds are adsorbed on the iron surface according to a Frumkin isotherm. The inhibition efficiency and the mode of adsorption of these compounds have been explained on the basis of nature of substituents and stability of conformers in the seven-membered ring of 1,5- benzodiazepin 2-one. The effect of temperature in the range 18-50 °C indicates that the protection efficiency decreases very slightly when the temperature increases. Apparent activation energies were determined

Methyl 2-oxo-2,3-dihydro-1,3-benzothiazole-3-acetate

The title compound, C10H9NO3S, crystallizes with two molecules in the asymmetric unit. The crystal packing is stabilized by van der Waals forces

1-(1,3-Benzothiazol-2-yl)propan-2-ol

In the title compound, C10H11NOS, the asymmetric unit contains two molecules. The structure is stabilized by an intermolecular O-(HN)-N-... hydrogen bond