Synthesis and reactivity of new heterocyclic systems derived from 5-chloro-1H-indole-2,3-dione

In this article, we described the synthesis of various derivatives of 5-Chloroisatin by the action of halogenated mono channels, benzyl chloride and methyl iodide under the conditions of phase transfer catalysis (PTC), which are widely used as a starting material for the synthesis of heterocyclic compounds and as substrates for the synthesis of drugs. In order to multiply the family heterocyclic compound from 5-Chloro-1H-indole-2,3-dione using the N-alkylation reaction which is answered in the field of organic chemistry and on which several studies were performed. The various products were determined by 1H NMR, and 13C NMR spectroscopy with good yield

SYNTHESIS OF NEW 5-BROMO-1H-INDOLE-2,3-DIONE DERIVATIVES BY 1,3-DIPOLAR CYCLOADDITION

To contribute to the development of the chemistry of 5-bromo-isatin, we have synthesized new heterocyclic systems, using alkylation reactions under conditions of phase transfer catalysis to be then subjected to cycloaddition reactions dipolar involving 1,3-dipoles. The structures of the various products obtained were determined by 1H NMR, 13C NMR spectroscopy

Imidazo[4,5-b]pyridines as a New Class of Corrosion Inhibitors for Mild Steel: Experimental and DFT Approach

6-Bromo-2-methyl-1H-imidazo[4,5-b]pyridine (P1), was investigated for its adsorption and corrosion inhibition traits for mild steel corrosion in 1.0 M HCl solution. Gravimetric, potentiodynamic polarization and electrochemical impedance spectroscopy methods, were used to test the nature of adsorption and the inhibition effect of P1 on the mild steel in acidic media. It was found that the inhibition efficiency improved with the increase of P1 concentration in the acid solution (1.0 M HCl). The adsorption of P1 favored Langmuir adsorption isotherm. The results of corrosion tests confirmed that P1 could serve as an efficient corrosion inhibitor for the mild steel in 1.0 M HCl solution, yielding a high efficiency and low risk of environmental pollution. The theoretical quantum chemical calculations were in good correlation with the experimental result

Synthesis of 6-chloro-2-oxo-1,2-dihydroquinoline-4-carbohydrazide

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1H and 13C \NMR\ spectra of condensed benzimidazole and imidazobenzodiazepines

International audienceBenzimidazoles are heterocyclic compounds that have awakened great interest during the last few years because of their proven biological activity as antiviral, antimicrobial, and antitumoral agents. For this reason, the development of a systematic \NMR\ study of condensed benzimidazole compounds constitutes a significant tool in understanding the molecular dynamics and the structural parameters that govern their behavior. The 1H and 13C \NMR\ spectra of new imidazobenzodiazepines were investigated. Based on the study of \NMR\ chemical shifts, we discuss the environmental effect of the nucleus 13C. The correlation 1H-13C proved to be a useful method for distinguishing the assignment of carbon

Ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin -3-yl)methyl]-1H-1,2,3-triazol-1-yl}acetate

The reaction of 1,5-dibenzyl-3-propargyl-1,5-benzodiazepine-2,4-dione with ethyl azidoacetate in the presence of copper sulfate pentahydrate and sodium ascorbate leads to the formation of the title regioisomer, C(30)H(29)N(5)O(4), which features a phenylene ring fused with a seven-membered diazepinyl ring. The latter ring adopts a boat conformation (with the methyltriazolylacetate-bearing C atom as the prow and the fused-ring C atoms as the stern). The benzyl groups connected to the diazepinyl ring jprotrude from the sides; the methyltriazolylacetate substituent occupies an axial position

6-Bromo-1,3-dimethyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The non-H atoms of the two independent molecules in the asymmetric unit of the title compound, C(8)H(8)BrN(3)O, are planar (r.m.s. deviations = 0.015 and 0.019 A). In the crystal, the molecules are linked into a zigzag chain along the c axis by C-H...O hydrogen bonds