Relationship of atherosclerosis and atrial fibrillation predictors with body composition in obese individuals

Aim: To investigate the markers that may predict both atrial fibrillation (AF) and atherosclerosis in obese patients. Method: This study was conducted on 108 participants (54 women and 54 men) with a body mass index (i.e., BMI) of at least 30. In addition to the electrocardiogram (ECG) and transthoracic echocardiography (TTE) findings, we also analyzed the findings of body composition by means of the bioelectric impedance analysis method using the Tanita MC 780 MA analyzer in all participants. Results: We found that the minimal area of the left atrium (LA) had a very strong (r = 0.978, p = 0.022) correlation with visceral adiposity and a weak positive correlation with waist circumference. Aortic stiffness had a weak positive correlation with visceral adiposity ratio (p = 0.022) and fat mass (r = 0.323, p = 0.001). The diameter of LA had weak positive correlations with visceral adiposity (p = 0.018), waist circumference (r = 0.336, p < 0.001), fat-free mass (r = 0.323, p = 0.001), muscle mass (r = 0.324, p = 0.001), liquid mass (r = 0.323, p = 0.001) and metabolic age (r = 0.364, p < 0.001). Again, we found weak positive correlations of epicardial fat tissue with visceral adiposity (r = 0.459, p = 0.018) and metabolic age (r = 0.350, p < 0.001). Conclusions: In our study, it has been noted that obese patients may have different levels of risk for AF and atherosclerosis, and there may be a more risky subgroup in which the distribution of some anthropometric and body tissue components differs

A Case of Adrenal Incidentaloma: Diagnosed Pheochromocytoma during Uncontrolled Diabetes Mellitus Follow-up [Bir Adrenal Insidentaloma Olgusu: Kontrolsuz Diabetes Mellitus Takibinde Feokromositoma Tanisi]

Adrenal incidentalomas are serendipitously discovered by radiologic examination. Whether malignant mass and hormonal activity are two basic questions that need to be explained. Obtained radiological imaging features are very important and they are also guiding for diagnosis. Diagnostic biopsy of the lesion can be done but not used in routine. Although the majority of lesions in terms of hormonal activity are nonfunctional, patients can have different signs and symptoms. Therefore, they cant attract the attention of the clinician until incidentally detected mass. Despite treatment modifications, we can not be achieved diabetic control in our case. We detected adrenal incidentaloma during follow-up, we are faced with an asymptomatic cases of pheochromocytoma. Surgical treatment was provided with both laboratory and clinical stabilization of the patients. [Med-Science 2016; 5(2.000): 683-92

Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes

<div><p>ABSTRACT Objective To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. Subjects and methods Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed. Results Serum nesfatin-1 levels were found to be lower in women with gestational diabetes compared to the pregnant women in the control sample (p = 0.020). Multiple linear regression analysis revealed that nesfatin-1 was lower in participants with gestational diabetes independently from gestational age, BMI, HOMA-IR, fasting plasma glucose, and age. In correlation analysis, the only variable that was found to have a statistically significant correlation with nesfatin-1 was gestational age (p = 0.015, r = 0.30). Conclusion Lower nesfatin-1 levels in women with gestational diabetes compared to the control group at 24-28 weeks of gestation draws attention to nesfatin-1 levels in gestational diabetes and motivates further research in this area.</p></div

The acromegaly registry of ten different centers in Turkey

Objectives: To describe biochemical and clinical features, and therapeutic outcomes of acromegaly patients in Turkey