2 research outputs found
Informe cient铆fico de Beca de Entrenamiento: Espector, Natalia Mercedes (2014-2015)
La Terapia por Captura Neutrónica de Boro (BNCT) es una metodología en desarrollo para el tratamiento de tumores que responden pobremente ante las terapias convencionales (Coderre et al., 2003, Barth et al., 2012; Moss, 2014).
La misma se basa en la alta sección eficaz de captura del isótopo para neutrones t茅rmicos, produci茅ndose la reacci贸n $latex ^{10}B(n,\alpha) ^{7}Li
Evaporation process in histological tissue sections for neutron autoradiography
The analysis of the distribution and density of nuclear tracks forming an autoradiography in a nuclear track detector (NTD) allows the determination of 10B atoms concentration and location in tissue samples from Boron Neutron Capture Therapy (BNCT) protocols. This knowledge is of great importance for BNCT dosimetry and treatment planning. Tissue sections studied with this technique are obtained by cryosectioning frozen tissue specimens. After the slicing procedure, the tissue section is put on the NTD and the sample starts drying. The thickness varies from its original value allowing more particles to reach the detector and, as the mass of the sample decreases, the boron concentration in the sample increases. So in order to determine the concentration present in the hydrated tissue, the application of corrective coefficients is required. Evaporation mechanisms as well as various factors that could affect the process of mass variation are outlined in this work. Mass evolution for tissue samples coming from BDIX rats was registered with a semimicro analytical scale and measurements were analyzed with software developed to that end. Ambient conditions were simultaneously recorded, obtaining reproducible evaporation curves. Mathematical models found in the literature were applied for the first time to this type of samples and the best fit of the experimental data was determined. The correlation coefficients and the variability of the parameters were evaluated, pointing to Page鈥檚 model as the one that best represented the evaporation curves. These studies will contribute to a more precise assessment of boron concentration in tissue samples by the Neutron Autoradiography technique.Fil: Espector, Natalia. Universidad Favaloro; Argentina. Provincia de Buenos Aires. Gobernaci贸n. Comisi贸n de Investigaciones Cient铆ficas; ArgentinaFil: Portu, Agustina Mariana. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas; Argentina. Comisi贸n Nacional de Energ铆a At贸mica; ArgentinaFil: Santa Cruz, Gustavo Alberto. Comisi贸n Nacional de Energ铆a At贸mica; ArgentinaFil: Saint Martin, Mar铆a Laura Gisela. Comisi贸n Nacional de Energ铆a At贸mica; Argentina. Universidad Nacional de San Mart铆n. Instituto Sabato; Argentin