743 research outputs found
Impact of Gene-Gender Effects of Adrenergic Polymorphisms on Hypothalamic-Pituitary-Adrenal Axis Activity in Depressed Patients
Objective: There is overwhelming evidence that activation of the hypothalamic-pituitary-adrenal (HPA) system plays a major role in depression and cardiovascular disease in genetically susceptible individuals. We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major depression. Methods: Using the dexamethasone/corticotrophin-releasing hormone (DEX/CRH) test, we investigated the association of alpha 2-adrenoceptor (ADRA2A -1291C -> G) and the beta 2-adrenoceptor gene (ADRB2 Arg16Gly) in 189 patients with major depression during the acute state of the disease and after remission. Results: Male ADRA2A -1291G allele homozygotes showed significant pretreatment HPA axis hyperactivity, with increased adrenocorticotropin (ACTH; F = 4.9, d.f. = 2, p = 0.009) and cortisol responses (F = 6.4, d.f. = 2, p = 0.003). In contrast, female ADRB2 Arg/Arg homozygotes had increased pretreatment ACTH (F = 7.17, d.f. = 2, p = 0.001) and cortisol (F = 8.95, d.f. = 2, p = 0.000) levels. Interestingly, in the respective genotypes, the stress hormones remained elevated in the second DEX/CRH test, despite a reduction in depressive symptoms. Conclusions: This study provides evidence that, depending on gender and polymorphisms, there is continuous HPA axis overdrive in a proportion of patients irrespective of the status of depression. Considering the importance of stress hormones for cardiovascular disorders, our data might suggest that these patients are at high risk of comorbidity between depression and cardiovascular disorders. Copyright (c) 2008 S. Karger AG, Base
Binomial Ideals and Congruences on Nn
Producción CientÃficaA congruence on Nn is an equivalence relation on Nn that is compatible with the additive structure. If k is a field, and I is a binomial ideal in k[X1,…,Xn] (that is, an ideal generated by polynomials with at most two terms), then I induces a congruence on Nn by declaring u and v to be equivalent if there is a linear combination with nonzero coefficients of Xu and Xv that belongs to I. While every congruence on Nn arises this way, this is not a one-to-one correspondence, as many binomial ideals may induce the same congruence. Nevertheless, the link between a binomial ideal and its corresponding congruence is strong, and one may think of congruences as the underlying combinatorial structures of binomial ideals. In the current literature, the theories of binomial ideals and congruences on Nn are developed separately. The aim of this survey paper is to provide a detailed parallel exposition, that provides algebraic intuition for the combinatorial analysis of congruences. For the elaboration of this survey paper, we followed mainly (Kahle and Miller Algebra Number Theory 8(6):1297–1364, 2014) with an eye on Eisenbud and Sturmfels (Duke Math J 84(1):1–45, 1996) and Ojeda and Piedra Sánchez (J Symbolic Comput 30(4):383–400, 2000).National Science Foundation (grant DMS-1500832)Ministerio de EconomÃa, Industria y Competitividad (project MTM2015-65764-C3-1)Junta de Extremadura (grupo de investigación FQM-024
Solution of the Bosonic and Algebraic Hamiltonians by using AIM
We apply the notion of asymptotic iteration method (AIM) to determine
eigenvalues of the bosonic Hamiltonians that include a wide class of quantum
optical models. We consider solutions of the Hamiltonians, which are even
polynomials of the fourth order with the respect to Boson operators. We also
demonstrate applicability of the method for obtaining eigenvalues of the simple
Lie algebraic structures. Eigenvalues of the multi-boson Hamiltonians have been
obtained by transforming in the form of the single boson Hamiltonian in the
framework of AIM
The Size of the Narrow-Line Emitting Region in the Seyfert 1 Galaxy NGC 5548 from Emission-Line Variability
The narrow [O III] 4959, 5007 emission-line fluxes in the spectrum of the
well-studied Seyfert 1 galaxy NGC 5548 are shown to vary with time. From this
we show that the narrow line-emitting region has a radius of only 1-3 pc and is
denser (n ~ 10^5 cm^{-3}) than previously supposed. The [O III] line width is
consistent with virial motions at this radius given previous determinations of
the black hole mass.Since the [O III] emission-line flux is usually assumed to
be constant and is therefore used to calibrate spectroscopic monitoring data,
the variability has ramifications for the long-term secular variations of
continuum and emission-line fluxes, though it has no effect on shorter-term
reverberation studies. We present corrected optical continuum and broad Hbeta
emission-line light curves for the period 1988 to 2008.Comment: 11 pages, 5 figures, 6 tables. Accepted for publication in Ap
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Mediating punitiveness: understanding public attitudes towards work-related fatality cases
This paper concerns an empirical investigation into public attitudes towards work-related fatality cases, where organizational offenders cause the death of workers or members of the public. This issue is particularly relevant following the introduction of the Corporate Manslaughter and Corporate Homicide Act 2007 into UK law. Here, as elsewhere, the use of criminal law against companies reflects governmental concerns over public confidence in the law’s ability to regulate risk. The empirical findings demonstrate that high levels of public concern over these cases do not translate into punitive attitudes. Such cases are viewed rationally and constructively, and lead to instrumental rather than purely expressive enforcement preferences
Characterization of deposits formed on diesel injectors in field test and from thermal oxidative degradation of n-hexadecane in a laboratory reactor
Solid deposits from commercially available high-pressure diesel injectors (HPDI) were analyzed to study the solid deposition from diesel fuel during engine operation. The structural and chemical properties of injector deposits were compared to those formed from the thermal oxidative stressing of a diesel fuel range model compound, n-hexadecane at 160°C and 450 psi for 2.5 h in a flow reactor. Both deposits consist of polyaromatic compounds (PAH) with oxygen moieties. The similarities in structure and composition of the injector deposits and n-hexadecane deposits suggest that laboratory experiments can simulate thermal oxidative degradation of diesel in commercial injectors. The formation of PAH from n-hexadecane showed that aromatization of straight chain alkanes and polycondensation of aromatic rings was possible at temperatures as low as 160°C in the presence of oxygen. A mechanism for an oxygen-assisted aromatization of cylcoalkanes is proposed
POEMMA: Probe Of Extreme Multi-Messenger Astrophysics
The Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) mission is being
designed to establish charged-particle astronomy with ultra-high energy cosmic
rays (UHECRs) and to observe cosmogenic tau neutrinos (CTNs). The study of
UHECRs and CTNs from space will yield orders-of-magnitude increase in
statistics of observed UHECRs at the highest energies, and the observation of
the cosmogenic flux of neutrinos for a range of UHECR models. These
observations should solve the long-standing puzzle of the origin of the highest
energy particles ever observed, providing a new window onto the most energetic
environments and events in the Universe, while studying particle interactions
well beyond accelerator energies. The discovery of CTNs will help solve the
puzzle of the origin of UHECRs and begin a new field of Astroparticle Physics
with the study of neutrino properties at ultra-high energies.Comment: 8 pages, in the Proceedings of the 35th International Cosmic Ray
Conference, ICRC217, Busan, Kore
Neuroactive steroids in depression and anxiety disorders: Clinical studies
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor. During major depression, there is a disequilibrium of 3 alpha-reduced neuroactive steroids, which is corrected by clinically effective pharmacological treatment. To investigate whether these alterations are a general principle of successful antidepressant treatment, we studied the impact of nonpharmacological treatment options on neuroactive steroid concentrations during major depression. Neither partial sleep deprivation, transcranial magnetic stimulation, nor electroconvulsive therapy affected neuroactive steroid levels irrespectively of the response to these treatments. These studies suggest that the changes in neuroactive steroid concentrations observed after antidepressant pharmacotherapy more likely reflect distinct pharmacological properties of antidepressants rather than the clinical response. In patients with panic disorder, changes in neuroactive steroid composition have been observed opposite to those seen in depression. However, during experimentally induced panic induction either with cholecystokinine-tetrapeptide or sodium lactate, there was a pronounced decline in the concentrations of 3 alpha-reduced neuroactive steroids in patients with panic disorder, which might result in a decreased GABAergic tone. In contrast, no changes in neuroactive steroid concentrations could be observed in healthy controls with the exception of 3 alpha,5 alpha-tetrahydrodeoxycorticosterone. The modulation of GABA(A) receptors by neuroactive steroids might contribute to the pathophysiology of depression and anxiety disorders and might offer new targets for the development of novel anxiolytic compounds. Copyright (c) 2006 S. Karger AG, Basel
Influence of bisphosphonate therapy on bone geometry, volumetric bone density and bone strength of femoral shaft in postmenopausal women with rheumatoid arthritis
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