Acompañar(nos) desde el sentir

Construir redes desde adentro, desde y para les estudiantes, se torna una necesidad en un contexto donde prevalecen valores como el individualismo, la meritocracia, entre otros tantos que nos encierran; donde predomina el aumento de las desigualdades debido a la crisis económica y sociosanitaria, que se traduce en mayor deserción estudiantil en nuestra universidad pública.Este trabajo forma parte de la revista: Cuadernos de Coyuntura, número 5, editada por la Facultad de Ciencias Sociales de la Universidad Nacional de Córdoba, fue publicado el 23 de junio de 2021. Se encuentra dedicado a los: “Jóvenes. Pensar y sentir la pandemia”. Los trabajos han sido escritos por estudiantes de grado y las presentaciones por docentes de la misma Facultad. Es un espacio que nos permite escuchar las voces y los sentires de los jóvenes, en este particular momento que vive la sociedad toda. NDLR. Enlace al Portal de Revistas de la Universidad Nacional de Córdoba https://revistas.unc.edu.ar/index.php/CuadernosConyuntura/issue/view/2316publishedVersionFil: Nieto, María Ana. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Escudero Romano, Catalina. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field