Evaluation of the Linear Relationship Between Pulse Arrival Time and Blood Pressure in ICU Patients: Potential and Limitations

A variety of techniques based on the indirect measurement of blood pressure (BP) by Pulse Transit Time (PTT) have been explored over the past few years. Such an approach has the potential in providing continuous and non-invasive beat to beat blood pressure without the use of a cuff. Pulse Arrival Time (PAT) which includes the cardiac pre-ejection period has been proposed as a surrogate of PTT, however, the balance between its questioned accuracy and measurement simplicity has yet to be established. The present work assessed the degree of linear relationship between PAT and blood pressure on 96 h of continuous electrocardiography and invasive radial blood pressure waveforms in a group of 11 young ICU patients. Participants were selected according to strict exclusion criteria including no use of vasoactive medications and presence of clinical conditions associated with cardiovascular diseases. The average range of variation for diastolic BP was 60 to 79 mmHg while systolic BP varied between 123 and 158 mmHg in the study database. The overall Pearson correlation coefficient for systolic and diastolic blood pressure was −0.5 and −0.42, respectively, while the mean absolute error was 3.9 and 7.6 mmHg. It was concluded that the utilization of PAT for the continuous non-invasive blood pressure estimation is rather limited according to the experimental setup, nonetheless the correlation coefficient performed better when the range of variation of blood pressure was high over periods of 30 min suggesting that PAT has the potential to be used as indicator of changes relating to hypertensive or hypotensive episodes

Applications and identification of surface correlations

We compare theoretical, experimental, and computational approaches to random rough surfaces. The aim is to produce rough surfaces with desirable correlations and to analyze the correlation functions extracted from the surface profiles. Physical applications include ultracold neutrons in a rough waveguide, lateral electronic transport, and scattering of longwave particles and waves. Results provide guidance on how to deal with experimental and computational data on rough surfaces. A supplemental goal is to optimize the neutron waveguide for GRANIT experiments. The measured correlators are identified by fitting functions or by direct spectral analysis. The results are used to compare the calculated observables with theoretical values. Because of fluctuations, the fitting procedures lead to inaccurate physical results even if the quality of the fit is very good unless one guesses the right shape of the fitting function. Reliable extraction of the correlation function from the measured surface profile seems virtually impossible without independent information on the structure of the correlation function. Direct spectral analysis of raw data rarely works better than the use of a "wrong" fitting function. Analysis of surfaces with a large correlation radius is hindered by the presence of domains and interdomain correlations

Testing lorentz and CPT invariance with ultracold neutrons

In this paper we investigate, within the standard model extension framework, the influence of Lorentz- and CPT-violating terms on gravitational quantum states of ultracold neutrons. Using a semiclassical wave packet, we derive the effective nonrelativistic Hamiltonian which describes the neutrons vertical motion by averaging the contributions from the perpendicular coordinates to the free falling axis. We compute the physical implications of the Lorentz- and CPT-violating terms on the spectra. The comparison of our results with those obtained in the GRANIT experiment leads to an upper bound for the symmetries-violation c(mu nu)(n) coefficients. We find that ultracold neutrons are sensitive to the a(i)(n) and e(i)(n) coefficients, which thus far are unbounded by experiments in the neutron sector. We propose two additional problems involving ultracold neutrons which could be relevant for improving our current bounds; namely, gravity-resonance spectroscopy and neutron whispering gallery wave.CONACyT [234745, 234774