Regulatory networks related to competence development in Bacillus subtilis.

Na de voltooiing van het sequencen van het gehele genoom van de Gram-positieve bacterie Bacillus subtilis, werd een collectie van mutanten gemaakt voor alle genen met een onbekende functie. Als een onderdeel van een spin-off project van dit Bacillus subtilis genfunctie analyse project, het BACELL Netwerk project, hebben we de algemene regulatoire gen-netwerken bestudeerd, die deze bacterie in staat stellen te reageren op veranderende omstandigheden in haar milieu. We hebben ons specifiek gericht op één van deze adaptaties: het genetisch bepaalde vermogen om transformeerbaar te worden (genaamd competentie). Zie: Samenvatting

Impact of early childhood caries and its treatment under general anesthesia on orofacial function and quality of life : a prospective comparative study

Early Childhood Caries (ECC) has become a major public health concern worldwide, mostly affecting children from disadvantaged families in increasingly severe forms. This condition has been frequently reported to alter children?s nutrition, growth and general development. It negatively impacts their quality of life, through painful episodes and severe eating difficulties. While this period is crucial for oral praxes development, the impact of dental state on oro-facial functions is poorly documented. This study evaluated the impact of ECC and its treatment under general anesthesia on oro-facial functions and quality of life in pre-school children. The dysfunction and quality of life scores from 25 children with ECC were evaluated before treatment (T0), one month (T1) and three months after treatment (T2), using the Nordic Orofacial Test-Screening (NOT-S) and the Early Childhood Oral Health Impact Scale (ECOHIS), respectively, in comparison with 16 caries-free children. The number and extent of inter-arch dental contacts were also observed. The pre-operative higher NOT-S score observed in children with ECC decreased to reach the control level at T2. The mastication item was the most affected in the ECC group throughout the study. Their mean ECOHIS score also significantly decreased post-operatively and differences remaining between both groups were no longer clinically relevant. In addition, in children with ECC, values of functional inter-arch surfaces tended to increase over the follow-up period. Oro-facial functions and quality of life, altered by ECC, could be restored through a conservative treatment approach. Relations between dental state, orofacial functions and particularly chewing, and nutrition should be investigated further

Can the new French Case Mix identify patients requiring Special Care Dentistry?

International audienc

A qualitative study of the impact of an undergraduate clinical module in Special Care Dentistry on student learning and subsequent professional practice

International audienc

Identifying people requiring special care dentistry: A scoping review

International audienceAbstract Aims This scoping review aimed to document tools designed to identify persons requiring special care dentistry (SCD) and to provide a better understanding of the factors that justify adaptation in the provision of care. Methods A scoping review methodology was applied. An electronic search was performed in April 2021 using Pubmed and Embase. Additional tools were sought using hand searches and informal professional networking. Results Ten tools were identified that either predict the complexity of dental management or that retrospectively judge the complexity of care, of which two are as yet unpublished. Some had been developed for a specific population (e.g., patients with Alzheimer's disease, with learning disability, elderly persons) whilst others were applicable for any population (case mix tools). Factors considered included the patient's medical history, ability to cooperate, physical and cognitive autonomy, communication skills, anxiety, need for sedation, oral risk factors, ability to consent and the administrative burden for the dentist. Conclusion Identifying persons requiring SCD is possible by looking at various factors that influence the provision of dental care. There may be need for adaptation of tools to local circumstances and to the intended usage of the tool at a health services, systems or policy level

Étude de l’accès à un parcours de soins spécifique pour les personnes vulnérables.

National audienc

Evolution fonctionnelle et staturopondérale des enfants traités pour caries précoces

National audienc

Identifying Persons with Special Healthcare Needs in Dentistry—Development and Validation of the French Case Mix Tool

Providing dental care for certain patient groups is complicated due to difficulties with cooperation, communication, health conditions, and social context, amongst others. The majority of dentists in France work within a public fee-per-item system. A new measure has been introduced providing a financial supplement to dentists for each episode of care for a patient with a severe disability. This supplement is justified by completion of the French Case Mix tool (FCM), a new measure designed to retrospectively identify episodes of dental care that have required adaptation and additional time or expertise. The aim of this study was to investigate the validity and psychometric properties of the FCM. The content validity of the tool was improved at each round of pilot development, involving 392 patient encounters. Test–retest data at 2 weeks for 12 fictional patient treatment episodes were collected from 51 dentists. This phase confirmed inter- and intra-dentist reproducibility, criterion validity, and interpretability. Retrospective analysis of 4814 treatment episodes nationally demonstrated high reliability, internal consistency, and construct validity. Overall, the FCM showed high validity and good psychometric properties. However, the impact of providing a financial supplement on improving access to care for persons with special needs has yet to be evaluated

Improvement of masticatory capability after full-mouth comprehensive dental treatment under general anesthesia for severe early childhood caries

International audienc