943 research outputs found

    Platelet count as a prognostic marker in intensive care

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    Ten-fold spectral resolution boosting using TEDI at the Mt. Palomar NIR Triplespec spectrograph

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    An optical technique called "interferometric spectral reconstruction" (ISR) is capable of increasing a spectrograph's resolution and stability by large factors, well beyond its classical limits. We have demonstrated a 6- to 11-fold increase in the Triplespec effective spectral resolution (R=2,700) to achieve R=16,000 at 4100 cm-^(1) to 30,000 at 9600 cm^(-1) by applying special Fourier processing to a series of exposures with different delays (optical path differences) taken with the TEDI interferometer and the near-infrared Triplespec spectrograph at the Mt. Palomar Observatory 200 inch telescope. The TEDI is an externally dispersed interferometer (EDI) used for Doppler radial velocity measurements on M-stars, and now also used for ISR. The resolution improvement is observed in both stellar and telluric features simultaneously over the entire spectrograph bandwidth (0.9-2.45 μm). By expanding the delay series, we anticipate achieving resolutions of R=45,000 or more. Since the delay is not continuously scanned, the technique is advantageous for measuring time-variable phenomena or in varying conditions (e.g. planetary fly-bys). The photon limited signal to noise ratio can be 100 times better than a classic Fourier Transform Spectrometer (FTS) due to the benefit of dispersion

    Proton-Neutron Interaction near Closed Shells

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    Odd-odd nuclei around double shell closures are a direct source of information on the proton-neutron interaction between valence nucleons. We have performed shell-model calculations for doubly odd nuclei close to 208^{208}Pb, 132^{132}Sn and 100^{100}Sn using realistic effective interactions derived from the CD-Bonn nucleon-nucleon potential. The calculated results are compared with the available experimental data, attention being focused on particle-hole and particle-particle multiplets. While a good agreement is obtained for all the nuclei considered, a detailed analysis of the matrix elements of the effective interaction shows that a stronger core-polarization contribution seems to be needed in the particle-particle case.Comment: 8 pages, 6 figures, Proccedings of the International Conference "Nuclear Structure and Related Topics", Dubna, Russia, September 2-6, 2003, to be published in Yadernaia Fizika (Physics of Atomic Nuclei

    Carrier-Induced Magnetic Circular Dichloism in the Magnetoresistive Pyrochlore Tl2Mn2O7

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    Infrared magnetic circular dichloism (MCD), or equivalently magneto-optical Kerr effect, has been measured on the Tl2Mn2O7 pyrochlore, which is well known for exhibiting a large magnetoresistance around the Curie temperature T_C ~ 120 K. A circularly polarized, infrared synchrotron radiation is used as the light source. A pronounced MCD signal is observed exactly at the plasma edge of the reflectivity near and below T_c. However, contrary to the conventional behavior of MCD for ferromagnets, the observed MCD of Tl2Mn2O7 grows with the applied magnetic field, and not scaled with the internal magnetization. It is shown that these results can be basically understood in terms of a classical magnetoplasma resonance. The absence of a magnetization-scaled MCD indicates a weak spin-orbit coupling of the carriers in Tl2Mn2O7. We discuss the present results in terms of the microscopic electronic structures of Tl2Mn2O7.Comment: 5 pages, 5 figures, submitted to J. Phys. Soc. Jp

    Best practice considerations on the assessment of robotic assisted surgical systems:results from an international consensus expert panel

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    Background Health technology assessments (HTAs) of robotic assisted surgery (RAS) face several challenges in assessing the value of robotic surgical platforms. As a result of using different assessment methods, previous HTAs have reached different conclusions when evaluating RAS. While the number of available systems and surgical procedures is rapidly growing, existing frameworks for assessing MedTech provide a starting point, but specific considerations are needed for HTAs of RAS to ensure consistent results. This work aimed to discuss different approaches and produce guidance on evaluating RAS. Methods A consensus conference research methodology was adopted. A panel of 14 experts was assembled with international experience and representing relevant stakeholders: clinicians, health economists, HTA practitioners, policy makers, and industry. A review of previous HTAs was performed and seven key themes were extracted from the literature for consideration. Over five meetings, the panel discussed the key themes and formulated consensus statements. Results A total of ninety-eight previous HTAs were identified from twenty-five total countries. The seven key themes were evidence inclusion and exclusion, patient- and clinician-reported outcomes, the learning curve, allocation of costs, appropriate time horizons, economic analysis methods, and robotic ecosystem/wider benefits. Conclusions Robotic surgical platforms are tools, not therapies. Their value varies according to context and should be considered across therapeutic areas and stakeholders. The principles set out in this paper should help HTA bodies at all levels to evaluate RAS. This work may serve as a case study for rapidly developing areas in MedTech that require particular consideration for HTAs.</p

    Polymorphisms in PTK2 are associated with skeletal muscle specific force: an independent replication study

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    Purpose The aim of the study was to investigate two single nucleotide polymorphisms (SNP) in PTK2 for associations with human muscle strength phenotypes in healthy men. Methods Measurement of maximal isometric voluntary knee extension (MVCKE) torque, net MVCKE torque and vastus lateralis (VL) specific force, using established techniques, was completed on 120 Caucasian men (age = 20.6 ± 2.3 year; height = 1.79 ± 0.06 m; mass = 75.0 ± 10.0 kg; mean ± SD). All participants provided either a blood (n = 96) or buccal cell sample, from which DNA was isolated and genotyped for the PTK2 rs7843014 A/C and rs7460 A/T SNPs using real-time polymerase chain reaction. Results Genotype frequencies for both SNPs were in Hardy–Weinberg equilibrium (X 2 ≤ 1.661, P ≥ 0.436). VL specific force was 8.3% higher in rs7843014 AA homozygotes than C-allele carriers (P = 0.017) and 5.4% higher in rs7460 AA homozygotes than T-allele carriers (P = 0.029). No associations between either SNP and net MVCKE torque (P ≥ 0.094) or peak MVCKE torque (P ≥ 0.107) were observed. Conclusions These findings identify a genetic contribution to the inter-individual variability within muscle specific force and provides the first independent replication, in a larger Caucasian cohort, of an association between these PTK2 SNPs and muscle specific force, thus extending our understanding of the influence of genetic variation on the intrinsic strength of muscle.Published versio

    Western Irish Sea Nephrops Grounds (FU15) 2019 UWTV Survey Report and catch options for 2020

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    This report provides the main results and findings of the 17th annual underwater television survey on the ‘Irish sea west Nephrops grounds’ ICES assessment area, Functional Unit 15. The survey was multi-disciplinary in nature collecting UWTV and other ecosystem data. The 2019 design consisted of a randomised isometric grid of 100 stations at 4.5 nautical mile intervals out over the full known extent the stock. The resulting krigged burrow abundance estimate was 4.4 billion burrows. This was a similar result of that obtained in 2015, but a 10% lower than the abundance in 2018. In contrast to 2017 the spatial distribution of burrows shows a high density band on the central western area of the survey ground. The abundance remains within previously observed ranges and is above MSY Btrigger. The CV (or relative standard error) of 3% is in line with previous estimates and well below the upper limit of 20% recommended by SGNEPS 2012. Total catches and landings options at various different fishing mortalities were calculated and fishing at Fmsy in 2020 implies a total catch option at Fmsy (=Fmax) of 10,377 tonnes estimated to result in landings of no more than 8,546 tonnes. Sea-pens were observed at 21% of stations with high densities observed in the south-west of the ground. Trawl marks were noted at 15% of the UWTV stations

    Entropy-Dominated Dissipation in Sapphire Shock-Compressed up to 400 GPa (4 Mbar)

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    Sapphire (single-crystal Al2O3) is a representative Earth material and is used as a window and/or anvil in shock experiments. Pressure, for example, at the core-mantle boundary is about 130 gigapascals (GPa). Defects induced by 100-GPa shock waves cause sapphire to become opaque, which precludes measuring temperature with thermal radiance. We have measured wave profiles of sapphire crystals with several crystallographic orientations at shock pressures of 16, 23, and 86 GPa. At 23 GPa plastic-shock rise times are generally quite long (~100 ns) and their values depend sensitively on the direction of shock propagation in the crystal lattice. The long rise times are probably caused by the high strength of inter-atomic interactions in the ordered three-dimensional sapphire lattice. Our wave profiles and recent theoretical and laser-driven experimental results imply that sapphire disorders without significant shock heating up to about 400 GPa, above which Al2O3 is amorphous and must heat. This picture suggests that the characteristic shape of shock compression curves of many Earth materials at 100 GPa pressures is caused by a combination of entropy and temperature.Comment: 12 pages, 4 figure

    Half-metallic ferromagnets and their magneto-optical properties

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    We have calculated the electronic structure of PtMnSb in order to explain the very high magneto-optical Kerr effect (over 2.5° at 720 nm at room-temperature) of this compound. It is shown that this behavior is related to the unusual electronic properties of PtMnSb: it is a half-metallic ferromagnet like NiMnSb. The extreme asymmetry in the electronic structure of these compounds—metallic behavior for one spin direction and at the same time semiconducting behavior for the other spin direction—is responsible for the unusual magneto-optical properties
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