Deploying SDN architecture in Open Optical Transport Networks

Pro udrženı́ tempa s rostoucı́mi požadavky na přenosovou rychlost, latenci a bezpečnost je nutné zvážit současnou koncepci řı́zenı́ sı́tı́. Software-Defined Networking (SDN) je jedno z možných řešenı́, ke kterému telekomunikačnı́ průmysl směruje. Tato práce představuje současný stav Software-Defined Networking a zaměřuje se na vybraná open-source řešenı́ v oblasti SDN kontrolerů, jako je ONOS či OpenDaylight. Hlavnı́m cı́lem této části práce je vysvětlit, jak může SDN pomoci vyřešit rostoucı́ požadavky na rozšı́řenı́ automatizace v otevřených optických sı́tı́ch. Praktická část této práce je rozdělená do dvou oblastı́. V rámci prvnı́ oblasti jsem se zabýval rozšı́řenı́m funkčnosti SDN kontroleru pro umožněnı́ konfigurace a řı́zenı́ optických komunikačnı́ch zařı́zenı́. Hlavnı́m přı́nosem je implementace nových funkcionalit SDN driveru pro Nokia 1830 PSS (ROADM) a rozšı́řenı́ funkcionality driveru pro Nokia 1830 PSI-2T (optický transpondér). Ve druhé části práce jsem se zabýval problematikou korelace alarmů v otevřených optických sı́tı́ch. Výsledkem je funkce pro korelaci alarmů ve formě SDN aplikace, kterou jsem dále otestoval na emulovaných optických zařı́zenı́ch pro prokázánı́ funkčnosti celého konceptu.With the rising demands on the network throughput, latency and security, legacy control networking concepts should be reconsidered. Software-Defined Networking (SDN) is one of the possible solutions, to which telecommunication industry is moving. This work presents current state-of-the-art in Software-Defined Networking and focuses on some open-source solutions of SDN controllers, like ONOS and OpenDaylight. Main focus is to understand how SDN can help to solve increasing demand for broader automation in Optical Transport Networks. The practical section is divided in two parts. Within the first part I focused on extending functionality of SDN controller to facilitate more efficient configuration and control of optical network devices. Main contribution was to implement additional features to SDN drivers for Nokia 1830 PSS (ROADM) and extend functionality of Nokia 1830 PSI-2T (Optical Transponder) driver. Second part is dedicated to the Alarm Correlation problematic in open optical networks. We designed, developed an Alarm Correlation function as a SDN application then we tested it on emulated optical devices to prove the concept

Invariant Frechet algebras on bounded symmetric domains

Let D be a bounded domain in the complex vector space Cn . We say that D is symmetric iff, given any two points p, q ∈ D, there is a biholomorphism &phis;, which interchanges p and q. These domains were classified abstractly by Elie Cartan in his general study of symmetric spaces, and were canonically realized in Cn by Harish-Chandra. They include polydisks and Siegel domains. Let D be a bounded symmetric domain in Cn , and G be the largest connected group of biholomorphic automorphisms of D. The algebra C( D) of all continuous (not necessarily bounded) complex-valued functions on D with compact-open topology is a Frechet algebra. A closed subalgebra of C(D) is called an invariant algebra if it is closed under compositions with elements of G. We prove that if D is irreducible, then there are only three invariant algebras with identity with maximal ideal space D : C(D), the set of all holomorphic functions H(D) and the set of all antiholomorphic functions H¯(D). This result partially generalizes the Rudin\u27s classification of invariant algebras on unit ball in Cn . For the general symmetric bounded domain D we prove that the only invariant algebras are tensor products of invariant algebras on irreducible factors of D

Process control in the IoT concept

Tato práce se zabývá návrhem nízkonákladového systému v koncepci Internetu věcí pro dohled nad technologii galvanického vylučování kovů. Cílem je navrhnout funkční systém, který bude sbírat data a následně je zobrazovat. Součásti práce je též řešení problému spolehlivosti a bezpečnosti navrženého systému, včetně řešení problematiky ukládání dat v rámci omezené paměťové kapacity.This work deals with creating a system for controlling of electroforming process in IoT concept. The main aim is to create working system which can collect and show this data. Part of this work is also solving problem of reliability and security of created system and smart data storing in case of small memory capacity

bNAber: database of broadly neutralizing HIV antibodies.

The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous impetus to the HIV vaccine research and to entire immunology. The bNAber database at http://bNAber.org provides open, user-friendly access to detailed data on the rapidly growing list of HIV bNAbs, including neutralization profiles, sequences and three-dimensional structures (when available). It also provides an extensive list of visualization and analysis tools, such as heatmaps to analyse neutralization data as well as structure and sequence viewers to correlate bNAbs properties with structural and sequence features of individual antibodies. The goal of the bNAber database is to enable researchers in this field to easily compare and analyse available information on bNAbs thereby supporting efforts to design an effective vaccine for HIV/AIDS. The bNAber database not only provides easy access to data that currently is scattered in the Supplementary Materials sections of individual papers, but also contributes to the development of general standards of data that have to be presented with the discovery of new bNAbs and a universal mechanism of how such data can be shared

CT-guided Celiac Plexus Neurolysis in the Management of Severe Upper Abdominal Pain

Abdominal pain is a significant problem in patients with malignant tumors of the abdominal cavity, which dramatically affects the quality of life and survival. Chronic pain is experienced by about half of all cancer patients and more than 70  % in the late stages of the disease, the prevalence is even higher in patients with pancreatic cancer. Usually, pain management in a given cohort of patients is a very difficult issue, often requiring the chronic use of high doses of narcotic and non-narcotic analgesics or a combination thereof. Opioids are more effective, relieve pain, but have several side effects, causing nausea and vomiting, constipation, itching, dry mouth, severe sedation or delusions, hallucinogenic effects, the need to increase the dose as tolerance develops, and also intolerance to drugs. Inadequate pain management not only negatively impacts the quality of life but also correlates with poorer clinical survival rates for patients.The work deals with the anatomy of the celiac plexus (CP), features of innervation, comparison of different techniques of CP neurolysis, practical aspects of performing, indications and contraindications, possible complications, as well as recommendations for the successful conduct of CT-guided sympatholysis.Sympatholysis is a safe and effective way of treating severe pain in patients with malignant neoplasms of the upper half of the abdominal cavity. CP neurolysis should be used as one of the key techniques for a multidisciplinary approach to treatment, which provides significant relief of the pain syndrome intensity, reduces the use of opioid drugs and, thus, their side effects. A thorough understanding of the various methods and techniques allows the interventionist to optimize the approach for each patient and thus successfully carry out sympatholysis while minimizing complications

Черезшкірна радіочастотна селективна ризотомія гассерового вузла у лікуванні невралгії трійчастого нерва і кластерного головного болю

Мета: підвищити ефективність лікування пацієнтів при невралгії трійчастого нерва (НТН) та кластерному головному болю шляхом використання черезшкірної радіочастотної селективної ризотомії (ЧРСР) гассерового вузла. Матеріали і методи. Проаналізовано результати лікування 267 хворих з приводу НТН методом ЧРСР у період з 2011 по 2015 рр.; тривалість захворювання від 1 до 43 років. Також ЧРСР з приводу інтенсивного кластерного головного болю виконана у 4 хворих; тривалість захворювання від 2 до 27 років. Тривала консервативна терапія виявилася неефективною, що вимагало виконання хірургічного втручання. Результати. Після ЧРСР у 99 % хворих з НТН досягнуте цілковите усунення больового синдрому (БС). До кінця 1-ї доби після операції у 3 пацієнтів (1,1 %) виник рецидив болю. ЧРСР виконана повторно, досягнута виражена гіпалгезія, повний регрес БС. Ранні рецидиви БС, як правило, спостерігали у хворих, у яких під час ЧРСР не вдалося досягти достатнього рівня гіпестезії в зоні іннервації ураженої гілки трійчастого нерва (ТН). Проте при надмірно вираженій гіпестезії, яка сягає рівня аналгезії, виникала дизестезія, що вимагало відповідної корекції. Використання ЧРСР дозволило досягти стійкого регресу БС у 75 % хворих при кластерному головному болі у трирічний термін спостереження. Висновки. Перевагами міні-інвазивного методу ЧРСР при НТН і кластерному головному болі є безкровність і безпечність, скорочення тривалості втручання, застосування місцевої анестезії, відсутність вікових обмежень, висока ефективність

Artificial Epitope-Based Immunogens in HIV-Vaccine Design

One of the promising approaches for designing HIV vaccines is construction of synthetic polyepitope HIV-1 immunogen using a wide range of conservative T- and B-cell epitopes of the main virus antigens. In theory this approach helps cope with HIV-1 antigenic variability, focuses immune responses on protective determinants and enables to exclude from the vaccine compound adverse regions of viral proteins that can induce autoantibodies or antibodies enhancing infectivity of virus. The paper presents the experience of our team in development of artificial polyepitope HIV-1 immunogens, which can induce both a humoral response, and responses of cytotoxic (CD8 + CTL) and helpers (CD4 + Th) T-cells. The design of HIV-immunogens has been done using our original software, TEpredict and PolyCTLDesigner. We describe development of the candidate HIV-1/AIDS vaccine – CombiHIVvac, which included two artificial polyepitope immunogens TBI and TCI for stimulating humoral and cellular responses. The results of the specific activity and safety of CombiHIVvac vaccine, obtained during preclinical and clinical trials, are presented