401 research outputs found

    Social partnership and professional education

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    Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ рассматриваСтся влияниС ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… процСссов, происходящих Π² ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ, Π½Π° качСство прСдоставляСмых услуг. Π‘ΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠ΅ партнСрство способствуСт комплСксному Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΡŽ ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΈ ΠΏΠΎΠ²Ρ‹ΡˆΠ°Π΅Ρ‚ Ρ€Π΅ΠΉΡ‚ΠΈΠ½Π³ ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ Π² Π³Π»Π°Π·Π°Ρ… стСйкхолдСров. Π‘ΠΎΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹ΠΉ Π°ΡƒΠ΄ΠΈΡ‚ ΠΏΠ°Ρ€Ρ‚Π½Π΅Ρ€ΠΎΠ² ΡƒΠ²Π΅Π»ΠΈΡ‡ΠΈΠ²Π°Π΅Ρ‚ Ρ€Π΅ΠΏΡƒΡ‚Π°Ρ†ΠΈΠΎΠ½Π½Ρ‹ΠΉ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π». Π‘ΠΎΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹ΠΉ Π΄ΠΈΠ°Π»ΠΎΠ³, основанный Π½Π° ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠΌ Π°ΡƒΠ΄ΠΈΡ‚Π΅, позволяСт ΠΎΡ‚ дСкларативности ΠΏΠ΅Ρ€Π΅Ρ…ΠΎΠ΄ΠΈΡ‚ΡŒ ΠΊ Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌ.In the paper the influence of the social processes in the organization on the reputation opportunities of the organization is considered. The social partnership enhances complex development of the organization and raises an organization value for stakeholders. The social audit of partners increases reputation potential. The social dialogue based on social audit allows one to implement the programs better

    ПСнсионноС страхованиС Π² России: соврСмСнноС состояниС ΠΈ возмоТности трансформации

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    Β The article examines and analyzes the essence of pension relations in modern Russia. The aim of the article is to study and test the hypothesis that an important factor in ensuring the effectiveness of the Russian pension system is a clear definition of the essence of economic relations in it, as well as adequate legal and organizational formalization of these relations. The scientific novelty of the study lies in the analysis of the validity and adequacy of applying (from terminological to organizational and practical levels) the classical insurance principles in the organization of the pension system, as well as the possibilities of increasing the efficiency of this system on the basis of the insurance sector. The research methodology is based on the analysis of the genesis and current state of the Russian pension system. The results of the study indicate that the structure of the Russian pension system requires serious reorganization, in particular, a clear distinction between the insurance (pension insurance) and non-insurance (pension provision) segments. The authors substantiated that pension insurance should be based on the classical principles of life insurance, and insurers who have an appropriate license obtained under the Law β€œOn the organization of insurance business in the Russian Federation” should be involved in the implementation of this insurance. At the same time, non-state pension funds must either be transformed into life insurers, or acquire new functionality within the framework of pension provision (the non-insurance part of the pension system). The practical implementation of the research results and related recommendations will allow, according to the authors, to organically structure the insurance and non-insurance segments of the Russian pension system and increase its efficiency. The authors conclude that the construction of pension insurance on the basis of the classical principles of life insurance will make it possible to fully use the accumulated global and domestic experience of using life insurance as a reliable instrument for financing pensions. At the same time, it is necessary to extend to pension relations the norms of regulation of the insurance market and state insurance supervision, which have proven their effectiveness.  Авторы Π°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΡƒΡŽΡ‚ ΡΡƒΡ‰Π½ΠΎΡΡ‚ΡŒ пСнсионных ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΉ Π² соврСмСнной России. ЦСль исслСдования β€” ΠΏΡ€ΠΎΠ²Π΅Ρ€ΠΊΠ° Π³ΠΈΠΏΠΎΡ‚Π΅Π·Ρ‹ ΠΎ Ρ‚ΠΎΠΌ, Ρ‡Ρ‚ΠΎ Π²Π°ΠΆΠ½Ρ‹ΠΌ Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠΌ обСспСчСния эффСктивности российской пСнсионной систСмы являСтся Ρ‡Π΅Ρ‚ΠΊΠΎΠ΅ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ сущности экономичСских ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΉ Π²Π½ΡƒΡ‚Ρ€ΠΈ Π½Π΅Π΅, Π° Ρ‚Π°ΠΊΠΆΠ΅ ΠΈΡ… Π°Π΄Π΅ΠΊΠ²Π°Ρ‚Π½ΠΎΠ΅ ΠΏΡ€Π°Π²ΠΎΠ²ΠΎΠ΅ ΠΈ ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠ΅ ΠΎΡ„ΠΎΡ€ΠΌΠ»Π΅Π½ΠΈΠ΅. Научная Π½ΠΎΠ²ΠΈΠ·Π½Π° исслСдования Π·Π°ΠΊΠ»ΡŽΡ‡Π°Π΅Ρ‚ΡΡ Π² Π°Π½Π°Π»ΠΈΠ·Π΅ обоснованности ΠΈ адСкватности использования (ΠΎΡ‚ тСрминологичСского Π΄ΠΎ ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΎΠ½Π½ΠΎ-практичСского ΡƒΡ€ΠΎΠ²Π½Π΅ΠΉ) классичСских страховых ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏΠΎΠ² Π² ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ пСнсионной систСмы, Π° Ρ‚Π°ΠΊΠΆΠ΅ возмоТностСй ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΡΒ  эффСктивности этой систСмы Π½Π° основС страхового Π΄Π΅Π»Π°. Π’ основС ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ исслСдования Π»Π΅ΠΆΠΈΡ‚ Π°Π½Π°Π»ΠΈΠ· гСнСзиса ΠΈ соврСмСнного состояния российской пСнсионной систСмы. Показано, Ρ‡Ρ‚ΠΎ структура российской пСнсионной систСмы Ρ‚Ρ€Π΅Π±ΡƒΠ΅Ρ‚ ΡΠ΅Ρ€ΡŒΠ΅Π·Π½ΠΎΠΉ Ρ€Π΅ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ, Π² частности Ρ‡Π΅Ρ‚ΠΊΠΎΠ³ΠΎ разграничСния страхового (пСнсионноС страхованиС) ΠΈ нСстрахового (пСнсионноС обСспСчСниС) сСгмСнтов. Обосновано, Ρ‡Ρ‚ΠΎ пСнсионноС страхованиС Π΄ΠΎΠ»ΠΆΠ½ΠΎ ΠΎΡΠ½ΠΎΠ²Ρ‹Π²Π°Ρ‚ΡŒΡΡ Π½Π° классичСских ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏΠ°Ρ… страхования ΠΆΠΈΠ·Π½ΠΈ, Π° Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠ΅ΠΉ Π΄Π°Π½Π½ΠΎΠ³ΠΎ страхования Π΄ΠΎΠ»ΠΆΠ½Ρ‹ Π·Π°Π½ΠΈΠΌΠ°Ρ‚ΡŒΡΡ страховщики, ΠΈΠΌΠ΅ΡŽΡ‰ΠΈΠ΅ ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΡƒΡŽ Π»ΠΈΡ†Π΅Π½Π·ΠΈΡŽ, ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½ΡƒΡŽ Π² Ρ€Π°ΠΌΠΊΠ°Ρ… Π—Π°ΠΊΠΎΠ½Π°Β  «Об ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ страхового Π΄Π΅Π»Π° Π² Π Π€Β». ΠŸΡ€ΠΈ этом нСгосударствСнныС пСнсионныС Ρ„ΠΎΠ½Π΄Ρ‹ Π΄ΠΎΠ»ΠΆΠ½Ρ‹ Π»ΠΈΠ±ΠΎ Π±Ρ‹Ρ‚ΡŒ ΠΏΡ€Π΅ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½Ρ‹ Π² страховщиков ΠΆΠΈΠ·Π½ΠΈ, Π»ΠΈΠ±ΠΎ приобрСсти Π½ΠΎΠ²Ρ‹ΠΉ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π» Π²Β  Ρ€Π°ΠΌΠΊΠ°Ρ… пСнсионного обСспСчСния (нСстраховой части пСнсионной систСмы). ΠŸΡ€Π°ΠΊΡ‚ΠΈΡ‡Π΅ΡΠΊΠ°Ρ рСализация  Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² исслСдования ΠΈ связанных с Π½ΠΈΠΌΠΈ Ρ€Π΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°Ρ†ΠΈΠΉ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚, ΠΏΠΎ мнСнию Π°Π²Ρ‚ΠΎΡ€ΠΎΠ², ΠΎΡ€Π³Π°Π½ΠΈΡ‡Π½ΠΎ ΡΡ‚Ρ€ΡƒΠΊΡ‚ΡƒΡ€ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ страховой ΠΈ нСстраховой Π±Π»ΠΎΠΊΠΈ российской пСнсионной систСмы ΠΈΒ  повысит Π΅Π΅ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ. Авторы Π΄Π΅Π»Π°ΡŽΡ‚ Π²Ρ‹Π²ΠΎΠ΄, Ρ‡Ρ‚ΠΎ построСниС пСнсионного страхования Π½Π° Π±Π°Π·Π΅ классичСских ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏΠΎΠ² страхования ΠΆΠΈΠ·Π½ΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚ Π² ΠΏΠΎΠ»Π½ΠΎΠΉ ΠΌΠ΅Ρ€Π΅ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Ρ‚ΡŒ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½Ρ‹ΠΉ ΠΌΠΈΡ€ΠΎΠ²ΠΎΠΉ ΠΈ отСчСствСнный ΠΎΠΏΡ‹Ρ‚ использования страхования ΠΆΠΈΠ·Π½ΠΈ ΠΊΠ°ΠΊ Π½Π°Π΄Π΅ΠΆΠ½ΠΎΠ³ΠΎ инструмСнта финансирования пСнсий. ΠŸΡ€ΠΈ этом Π½Π° пСнсионныС ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎ Ρ€Π°ΡΠΏΡ€ΠΎΡΡ‚Ρ€Π°Π½ΠΈΡ‚ΡŒ ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€Π΄ΠΈΠ²ΡˆΠΈΠ΅ свою ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Π½ΠΎΡ€ΠΌΡ‹ рСгулирования страхового Ρ€Ρ‹Π½ΠΊΠ° ΠΈ государствСнного страхового Π½Π°Π΄Π·ΠΎΡ€Π°.

    OperonDB: a comprehensive database of predicted operons in microbial genomes

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    The fast pace of bacterial genome sequencing and the resulting dependence on highly automated annotation methods has driven the development of many genome-wide analysis tools. OperonDB, first released in 2001, is a database containing the results of a computational algorithm for locating operon structures in microbial genomes. OperonDB has grown from 34 genomes in its initial release to more than 500 genomes today. In addition to increasing the size of the database, we have re-designed our operon finding algorithm and improved its accuracy. The new database is updated regularly as additional genomes become available in public archives. OperonDB can be accessed at: http://operondb.cbcb.umd.ed

    A. Megill: the Danger of Sacralizing Memory

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    Π‘Ρ‚Π°Ρ‚ΡŒΡ поступила Π² Ρ€Π΅Π΄Π°ΠΊΡ†ΠΈΡŽ 15.12.2021; ΠΎΠ΄ΠΎΠ±Ρ€Π΅Π½Π° послС рСцСнзирования 25.12.2021; принята ΠΊ ΠΏΡƒΠ±Π»ΠΈΠΊΠ°Ρ†ΠΈΠΈ 30.12.2021.The article was submitted 15.12.2021; approved after reviewing 25.12.2021; accepted for publication 30.12.2021.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ рассматриваСтся вопрос ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡΡ… памяти ΠΈ историчСской Π½Π°ΡƒΠΊΠΈ Π² ΠΊΠΎΠ½Ρ†Π΅ΠΏΡ†ΠΈΠΈ историчСской эпистСмологии амСриканского историка Аллана МСгилла. На основС ΠΏΡ€ΠΎΠ΄Π΅Π»Π°Π½Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΠΎΠΊΠ°Π·Π°Π½Π° ΠΎΠΏΠ°ΡΠ½ΠΎΡΡ‚ΡŒ процСсса сакрализации историчСской памяти. ΠžΠ±ΡΡƒΠΆΠ΄Π°Π΅Ρ‚ΡΡ Ρ‚Π°ΠΊΠΆΠ΅ вопрос послСдствий, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡŽΡ‰ΠΈΠΉ с ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ΠΌ цСнности ΠΊΠΎΠ»Π»Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΠΉ историчСской памяти.The article discusses the relationship between memory and historical science in the concept of historical epistemology by American historian Allan Megill. Based on the analysis done, the danger of the process of sacralization of historical memory is shown. The article discusses the issue of consequences arising with the increase in the value of collective historical memory

    Features of Semantic Translation of Collective Historical Memory

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    The article was submitted 15.09.2022; approved after reviewing 30.09.2022; accepted for publication 15.10.2022.Π‘Ρ‚Π°Ρ‚ΡŒΡ поступила Π² Ρ€Π΅Π΄Π°ΠΊΡ†ΠΈΡŽ 15.09.2022; ΠΎΠ΄ΠΎΠ±Ρ€Π΅Π½Π° послС рСцСнзирования 30.09.2022; принята ΠΊ ΠΏΡƒΠ±Π»ΠΈΠΊΠ°Ρ†ΠΈΠΈ 15.10.2022.The article is devoted to the methodological problem of the interaction of individual and collective in the phenomenon of historical memory. The identification of specific features of collective memory, the nature and dynamics of collective memories allows, on the one hand, to conceptualize collective memory, to substantiate its ontological status, on the other, to reveal the features of the mechanisms of collective memories. The article analyzes such features of collective memory as conventionality, tradition, repeatability, selectivity, etc. The thesis about the ambivalent nature of collective historical memory as a process is defended.Π‘Ρ‚Π°Ρ‚ΡŒΡ посвящСна мСтодологичСской ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠ΅ взаимодСйствия ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΈ ΠΊΠΎΠ»Π»Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ Π² Ρ„Π΅Π½ΠΎΠΌΠ΅Π½Π΅ историчСской памяти. ВыявлСниС спСцифичСских особСнностСй ΠΊΠΎΠ»Π»Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΠΉ памяти, ΠΏΡ€ΠΈΡ€ΠΎΠ΄Ρ‹ ΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΊΠΎΠ»Π»Π΅ΠΊΡ‚ΠΈΠ²Π½Ρ‹Ρ… воспоминаний позволяСт, с ΠΎΠ΄Π½ΠΎΠΉ стороны, ΠΊΠΎΠ½Ρ†Π΅ΠΏΡ‚ΡƒΠ°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ ΠΊΠΎΠ»Π»Π΅ΠΊΡ‚ΠΈΠ²Π½ΡƒΡŽ ΠΏΠ°ΠΌΡΡ‚ΡŒ, ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Ρ‹Π²Π°Ρ‚ΡŒ Π΅Π΅ онтологичСский статус, с Π΄Ρ€ΡƒΠ³ΠΎΠΉ β€” Ρ€Π°ΡΠΊΡ€Ρ‹Π²Π°Ρ‚ΡŒ особСнности ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΠΎΠ² Ρ€Π°Π±ΠΎΡ‚Ρ‹ ΠΊΠΎΠ»Π»Π΅ΠΊΡ‚ΠΈΠ²Π½Ρ‹Ρ… воспоминаний. Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Ρ‚Π°ΠΊΠΈΡ… особСнностСй ΠΊΠΎΠ»Π»Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΠΉ памяти, ΠΊΠ°ΠΊ ΠΊΠΎΠ½Π²Π΅Π½Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ, Ρ‚Ρ€Π°Π΄ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅, ΠΏΠΎΠ²Ρ‚ΠΎΡ€ΡΠ΅ΠΌΠΎΡΡ‚ΡŒ, ΡΠ΅Π»Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΈ Ρ‚. Π΄. ΠžΡ‚ΡΡ‚Π°ΠΈΠ²Π°Π΅Ρ‚ΡΡ тСзис ΠΎΠ± Π°ΠΌΠ±ΠΈΠ²Π°Π»Π΅Π½Ρ‚Π½ΠΎΠΉ ΠΏΡ€ΠΈΡ€ΠΎΠ΄Π΅ ΠΊΠΎΠ»Π»Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΠΉ историчСской памяти ΠΊΠ°ΠΊ процСсса

    Astrocyte-induced positive integrated information in neuron-astrocyte ensembles

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    Integrated information is a quantitative measure from information theory of how tightly all parts of a system are interconnected in terms of information exchange. In this study we show that astrocytes, playing an important role in regulation of information transmission between neurons, may contribute to a generation of positive integrated information in neuronal ensembles. Analytically and numerically we show that the presence of astrocytic regulation of neurotransmission may be essential for this information attribute in neuroastrocytic ensembles. Moreover, the proposed β€œspiking-bursting” mechanism of generating positive integrated information is shown to be generic and not limited to neuron-astrocyte networks and is given a complete analytic description

    Evaluation of the effect of the furazane fragment on the NH acidity of 4- and 5-picrylaminobenzofurazanes in DMF and DMSO

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    The products of the reactions of picryl chloride with isomeric aminobenzofurazanes in DMF and DMSO were studied by means of nonaquoeus potentiometric titration. The effect of the position of the furazane fragment in 4- and 5-picrylaminobenzofurazanes on the NH acidity is considered. The electron-acceptor properties of the furazane fragment were evaluated via inclusion of the resulting data into the pK a-Οƒ correlation for 2,4,6-trinitrodiphenylamines. On this basis, conventional Hammett Οƒ constants were calculated for the furazane fragment located in the immediate vicinity of the N-H center and one position distant from it. Β© 2005 Pleiades Publishing, Inc

    The effect of voluntary hypoventilation in yoga breathing exercises on gas exchange and EEG activity in healthy trained subjects

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    Objective: to assess the effect of voluntary hypoventilation during yoga breathing exercises on gas exchange and EEG activity in a group of healthy, trained practitioners.Materials and methods: 25 volunteers (21 men and 4 women, average age 42.96 Β± 9.19 years) performed hypoventilation yoga exercises with a decrease in respiratory rate to 1–1.5 times/minute. Registration of respiratory rate, tidal volume and minute volume of breathing, gas analysis of exhaled air (PetCO2, FeO2) and spectral analysis of electroencephalogram (EEG) in gICA model were carried out during breathing with a frequency of 1–1.5 times/minute and during relatively free breathing with mental calculation.Results: Breathing with a frequency of 1–1.5 times/minute causes a decrease in minute volume of breathing, the development of alveolar hypoxia and hypercapnia, which leads to an increase in the power of some local components in the slow delta, theta and alpha EEG bands. In addition, breathing with a frequency of 1–1.5 times/minute is accompanied by a decrease in the alpha- and beta-power of some components, the sources of which are located in the motor areas of the cortex, but is also accompanied by an increase in the power of components with widespread scalp topography in beta and gamma bands.Conclusion: Voluntary hypoventilation during yoga breathing exercises leads to the development of alveolar hypoxia and hypercapnia, accompanied by an increase in the power of local components in the slow EEG bands. At the same time, the alpha and beta powers of components localized in the motor areas of the cortex decrease, which may be a consequence of muscle tension during slow breathing

    Influence of the material of weighing bottles on loss-on-drying reproducibility

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    One of the factors influencing the uncertainty of residual moisture measurements in biological medicinal products is the accumulation of electrostatic charge on the surfaces of weighing bottles and laboratory balances, which results in poor weighing reproducibility. The authors believe that the simplest and most economical solution to this problem is to use weighing bottles made of a conductive material, e.g. metal. The aim of the work was to evaluate the influence of the material of weighing bottles on the reproducibility of loss-on-drying (LOD) methods. Materials and methods: Model samples for the study were prepared from a sucrose-gelatin medium by lyophilisation and subsequent moisture sorption to achieve a certain residual moisture content. The authors assessed the samples’ mass uniformity using Shewhart’s X-charts, and analysed their residual moisture content using a loss-on-drying procedure with glass and metal weighing bottles. Statistical processing of the results was carried out by calculating the main statistical indicators: Student’s t-test and Fisher’s F-test. Results: Four batches of model samples were prepared and standardised in terms of average mass using Shewhart’s charts. The effect of weighing bottle materials was most pronounced at low residual moisture contents (less than 0.5%), with the relative standard deviation (RSD) values for the results obtained with glass and metal weighing bottles reaching 76% and 35%, respectively. For the samples with a higher residual moisture content (2–5%), the minimum RSDs with glass and metal weighing bottles were 15% and 6%, respectively. Conclusions: The study allowed for evaluating the influence of the material of weighing bottles on the results of LOD measurements and demonstrated a higher reproducibility with metal weighing bottles. This confirms the possibility of using metal weighing bottles in quality assessment of biological medicinal products for human use with LOD methods
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