2 research outputs found
Direct Heteroarylation of Tautomerizable Heterocycles into Unsymmetrical and Symmetrical Biheterocycles via Pd/Cu-Catalyzed Phosphonium Coupling
The direct cross-coupling of tautomerizable heterocycles with various unfunctionalized heteroarenes has been achieved through PyBroP-mediated and Pd/Cu-catalyzed sequential C–OH/C–H activation. The methodology allows a facile entry into novel diazine-azole biheterocyclic frameworks. Moreover, an unprecedented Pd-catalyzed phosphonium homocoupling of tautomerizable heterocycles was also developed to afford a direct synthetic route to symmetrical 1,2-, 1,3-, and 1,4-bidiazine units
Pd/Cu-Catalyzed C–H Arylation of 1,3,4-Thiadiazoles with (Hetero)aryl Iodides, Bromides, and Triflates
The direct C–H arylation of 1,3,4-thiadiazoles
with a wide range of (hetero)Âaryl iodides, bromides, and triflates
is described using a Pd/Cu-catalyzed protocol. The methodology is
compatible with substrates possessing electron-donating or electron-withdrawing
substituents and also tolerates sterically hindered aryl halides.
The utility of the developed protocol is demonstrated by a one-pot
C–H arylation-Suzuki coupling sequence