Pd/Cu-Catalyzed C–H
Arylation of 1,3,4-Thiadiazoles with (Hetero)aryl Iodides, Bromides,
and Triflates
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Abstract
The direct C–H arylation of 1,3,4-thiadiazoles
with a wide range of (hetero)aryl iodides, bromides, and triflates
is described using a Pd/Cu-catalyzed protocol. The methodology is
compatible with substrates possessing electron-donating or electron-withdrawing
substituents and also tolerates sterically hindered aryl halides.
The utility of the developed protocol is demonstrated by a one-pot
C–H arylation-Suzuki coupling sequence