Additional file 1: of Opportunities and challenges in incorporating ancillary studies into a cancer prevention randomized clinical trial

Consort diagram for primary analysis of SELECT. (PDF 9 kb

Amyloid in dementia associated with familial FTLD: not an innocent bystander

<div><p>Patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case–control study compared clinical features, fluorodeoxyglucose-positron emission tomography metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or Pittsburgh compound B-PET. Compared to the amyloid-negative patients, the amyloid-positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Our results suggest that in FTLD amyloid positivity is associated with a more Alzheimer’s disease-like pattern of neurodegeneration.</p></div

Vitamin-D related single nucleotide polymorphisms (SNPs) with p-values <0.05 and risk of pancreatic cancer from PanScan I-III (3,583 cases and 7,053 controls).

<p>^a After bonferroni correction (0.05/213) p-values < 0.0002 were considered significant</p><p>^b Odds ratios (ORs) were adjusted for age (≤50, 51–60, 61–70, 71–80, ≥81 years), sex, study, and population stratification by 5 eigenvectors for ethnic ancestry.</p><p>^c Odds ratios (ORs) are for the number of copies of the minor allele.</p><p>^d Phase refers to participation in PanScan I, II or III. For rs4668123 data was available only from PanScan phases II and III.</p><p>Vitamin-D related single nucleotide polymorphisms (SNPs) with p-values <0.05 and risk of pancreatic cancer from PanScan I-III (3,583 cases and 7,053 controls).</p

Pathway analysis for risk of pancreatic cancer and gene sets in the vitamin D pathway (3,583 cases and 7,053 controls)

<p>^aP-values account for number of SNPs within genes or within the overall pathway, but not for the total number of genes; Models were adjusted for age (≤50, 51–60, 61–70, 71–80, ≥81 years), sex, study and population stratification by 5 eigenvectors for ethnic ancestry.</p><p>Pathway analysis for risk of pancreatic cancer and gene sets in the vitamin D pathway (3,583 cases and 7,053 controls)</p

Novel and previously identified BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in African ancestry discovery and replication samples, and European ancestry replication samples.

<p>Novel and previously identified BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in African ancestry discovery and replication samples, and European ancestry replication samples.</p

Additional novel BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in sex-stratified analyses of African ancestry discovery and replication samples.

<p>Additional novel BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in sex-stratified analyses of African ancestry discovery and replication samples.</p