Can Adverse Effects of Poor Investor Protection Be Mitigated by Incoming Foreign Investment?

Anlegerschutz, Kleinaktionär, Direktinvestition, Regulierung, Investor protection, Small shareholders, Foreign direct investment, Regulation

Understanding Structure and Agency as Commercial Determinants of Health; Comment on “How Neoliberalism Is Shaping the Supply of Unhealthy Commodities and What This Means for NCD Prevention”

The limited success to date, by the public health community, to address the dramatic rise in non-communicable diseases (NCDs) has prompted growing attention to the commercial determinants of health. This has led to a much needed shift in attention, from metabolic and behavioural risk factors, to the production and consumption of health-harming products by the commercial sector. Building on Lencucha and Thow’s analysis of neoliberalism, in shaping the underlying policy environment favouring commercial interests, we argue for fuller engagement with structure and agency interaction when conceptualising, assessing, and identifying public health measures to address the commercial determinants of health

Cash Crop and Foodgrain Productivity in Senegal: Historical View, New Survey Evidence, and Policy Implications

Crop Production/Industries, Productivity Analysis, Downloads July 2008 - June 2009: 10,

Network positions in active learning environments in physics

This study uses positional analysis to describe the student interaction networks in four research-based introductory physics curricula. Positional analysis is a technique for simplifying the structure of a network into blocks of actors whose connections are more similar to each other than to the rest of the network. This method describes social structure in a way that is comparable between networks of different sizes and densities and can show large-scale patterns such as hierarchy or brokering among actors. We detail the method and apply it to class sections using Peer Instruction, SCALE-UP, ISLE, and context-rich problems. At the level of detail shown in the blockmodels, most of the curricula are more alike than different, showing a late-term tendency to form coherent subgroups that communicate actively among themselves but have few inter-position links. This pattern may be a network signature of active learning classes, but wider data collection is needed to investigate.Comment: 17 pages, 10 figures; supplemental 10 pages, 9 figure

The impact of xanthine oxidase (XO) on hemolytic diseases

Hemolytic diseases are associated with elevated levels of circulating free heme that can mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly by upregulating enzymatic sources of reactive species. A key enzymatic source of these reactive species is the purine catabolizing enzyme, xanthine oxidase(XO) as the oxidation of hypoxanthine to xanthine and subsequent oxidation of xanthine to uric acid generates superoxide (O2•-) and hydrogen peroxide (H2O2). While XO has been studied for over 120 years, much remains unknown regarding specific mechanistic roles for this enzyme in pathologic processes. This gap in knowledge stems from several interrelated issues including: 1) lethality of global XO deletion and the absence of tissue-specific XO knockout models have coalesced to relegate proof-of-principle experimentation to pharmacology; 2) XO is mobile and thus when upregulated locally can be secreted into the circulation and impact distal vascular beds by high-affinity association to the glycocalyx on the endothelium; and 3) endothelial-bound XO is significantly resistant (\u3e 50%) to inhibition by allopurinol, the principle compound used for XO inhibition in the clinic as well as the laboratory. While it is known that circulating XO is elevated in hemolytic diseases including sickle cell, malaria and sepsis, little is understood regarding its role in these pathologies. As such, the aim of this review is to define our current understanding regarding the effect of hemolysis (free heme) on circulating XO levels as well as the subsequent impact of XO-derived oxidants in hemolytic disease processes