126 research outputs found
Impacts of the Teach For America Investing in Innovation Scale-Up
In 2010, Teach For America (TFA) launched a major expansion effort, funded in part by a five-year Investing in Innovation (i3) scale-up grant of $50 million from the U.S. Department of Education. Using a rigorous random assignment design to examine the effectiveness of TFA elementary school teachers in the second year of the i3 scale-up, Mathematica Policy Research found that first- and second-year corps members recruited and trained during the scale-up were as effective as other teachers in the same high-poverty schools in both reading and math. To estimate the effectiveness of TFA teachers relative to the comparison teachers, we compared end-of-year test scores of students assigned to the TFA teachers and those assigned to the comparison teachers. Because students in the study were randomly assigned to teachers, we can attribute systematic differences in achievement at the end of the study school year to the relative effectiveness of TFA and comparison teachers, rather than to the types of students taught by these two different groups of teachers. In addition to the impact analysis described in this report, the evaluation included an implementation analysis that describes key features of TFA's program model and its implementation of the i3 scale-up
Assessing the Effectiveness of Teach For America's Investing in Innovation Scale-Up
In 2010, TFA launched a major expansion effort, funded in part by a five-year Investing in Innovation (i3) scale-up grant of $50 million from the U.S. Department of Education. By the 2012 -- 2013 school year -- the second year of the scale-up -- TFA had expanded its placements of first- and second-year corps members by 25 percent. This study examines the effectiveness of TFA elementary school teachers hired during the first two years of the i3 scale-up, relative to other teachers in the same grades and school
Binary neutron stars: Equilibrium models beyond spatial conformal flatness
Equilibria of binary neutron stars in close circular orbits are computed
numerically in a waveless formulation: The full Einstein-relativistic-Euler
system is solved on an initial hypersurface to obtain an asymptotically flat
form of the 4-metric and an extrinsic curvature whose time derivative vanishes
in a comoving frame. Two independent numerical codes are developed, and
solution sequences that model inspiraling binary neutron stars during the final
several orbits are successfully computed. The binding energy of the system near
its final orbit deviates from earlier results of third post-Newtonian and of
spatially conformally flat calculations. The new solutions may serve as initial
data for merger simulations and as members of quasiequilibrium sequences to
generate gravitational wave templates, and may improve estimates of the
gravitational-wave cutoff frequency set by the last inspiral orbit.Comment: 4 pages, 6 figures, revised version, PRL in pres
Access to Effective Teaching for Disadvantaged Students
Recent federal initiatives in education, such as Race to the Top, the Teacher Incentive Fund, and the flexibility policy for the Elementary and Secondary Education Act are designed in part to ensure that disadvantaged students have equal access to effective teaching. The initiatives respond to the concern that disadvantaged students may be taught by less effective teachers and that this could contribute to the achievement gap between disadvantaged students and other students. To address the need for evidence on this issue, the Institute of Education Sciences at the U.S. Department of Education initiated a study to examine access to effective teaching for disadvantaged students in 29 diverse school districts. Mathematica Policy Research and its partner, the American Institutes for Research, conducted the study, which focused on English/ language arts (ELA) and math teachers in grades 4 through 8 from the 2008 -- 2009 to the 2010 -- 2011 school year
Non-conformally flat initial data for binary compact objects
A new method is described for constructing initial data for a binary
neutron-star (BNS) system in quasi-equilibrium circular orbit. Two formulations
for non-conformally flat data, waveless (WL) and near-zone helically symmetric
(NHS), are introduced; in each formulation, the Einstein-Euler system, written
in 3+1 form on an asymptotically flat spacelike hypersurface, is exactly solved
for all metric components, including the spatially non-conformally flat
potentials, and for irrotational flow. A numerical method applicable to both
formulations is explained with an emphasis on the imposition of a spatial gauge
condition. Results are shown for solution sequences of irrotational BNS with
matter approximated by parametrized equations of state that use a few segments
of polytropic equations of state. The binding energy and total angular momentum
of solution sequences computed within the conformally flat --
Isenberg-Wilson-Mathews (IWM) -- formulation are closer to those of the third
post-Newtonian (3PN) two point particles up to the closest orbits, for the more
compact stars, whereas sequences resulting from the WL/NHS formulations deviate
from the 3PN curve even more for the sequences with larger compactness. We
think it likely that this correction reflects an overestimation in the IWM
formulation as well as in the 3PN formula, by cycle in the
gravitational wave phase during the last several orbits. The work suggests that
imposing spatial conformal flatness results in an underestimate of the
quadrupole deformation of the components of binary neutron-star systems in the
last few orbits prior to merger.Comment: 22 pages, 7 figure
Last orbits of binary strange quark stars
We present the first relativistic calculations of the final phase of inspiral
of a binary system consisting of two stars built predominantely of strange
quark matter (strange quark stars). We study the precoalescing stage within the
Isenberg-Wilson-Mathews approximation of general relativity using a multidomain
spectral method. A hydrodynamical treatment is performed under the assumption
that the flow is either rigidly rotating or irrotational, taking into account
the finite density at the stellar surface -- a distinctive feature with respect
to the neutron star case. The gravitational-radiation driven evolution of the
binary system is approximated by a sequence of quasi-equilibrium configurations
at fixed baryon number and decreasing separation. We find that the innermost
stable circular orbit (ISCO) is given by an orbital instability both for
synchronized and irrotational systems. This constrasts with neutron stars for
which the ISCO is given by the mass-shedding limit in the irrotational case.
The gravitational wave frequency at the ISCO, which marks the end of the
inspiral phase, is found to be 1400 Hz for two irrotational 1.35 Msol strange
stars and for the MIT bag model of strange matter with massless quarks and a
bag constant B=60 MeV/fm^3. Detailed comparisons with binary neutrons star
models, as well as with third order Post-Newtonian point-mass binaries are
given.Comment: 11 pages, 10 figures, improved conclusion and figures, references
added, accepted for publication in Phys. Rev.
attainment of treat to target endpoints in sle patients with high disease activity in the atacicept phase 2b address ii study
Abstract
Objective
Low disease activity (LDA) and remission are emerging treat-to-target (T2T) endpoints in SLE. However, the rates at which these endpoints are met in patients with high disease activity (HDA) are unknown. Atacicept, which targets B lymphocyte stimulator and a proliferation-inducing ligand, improved disease outcomes in SLE patients with HDA (SLEDAI-2K ≥10) at baseline in the phase 2b ADDRESS II study. This is a post hoc analysis of T2T endpoints in these patients.
Methods
Patients received weekly atacicept (75 or 150 mg s.c.) or placebo for 24 weeks (1:1:1 randomization). Attainment of three T2T endpoints, LDA (SLEDAI-2K ≤ 2), Lupus Low Disease Activity State (LLDAS) and remission (clinical SLEDAI-2K = 0, prednisone-equivalent ≤5mg/day and Physician's Global Assessment <0.5), was assessed and compared with SLE Responder Index (SRI)-4 and SRI-6 response.
Results
Of 306 randomized patients, 158 (51.6%) had baseline HDA. At week 24, 37 (23.4%) HDA patients attained LDA, 25 (15.8%) LLDAS and 17 (10.8%) remission. Each of these endpoints was more stringent than SRI-4 (n = 87; 55.1%) and SRI-6 (n = 67; 42.4%). Compared with placebo (n = 52), at week 24, patients treated with atacicept 150 mg (n = 51) were more likely to attain LDA [odds ratio (OR) 3.82 (95% CI: 1.44, 10.15), P = 0.007], LLDAS [OR 5.03 (95% CI: 1.32, 19.06), P = 0.018] or remission [OR 3.98 (95% CI: 0.78, 20.15), P = 0.095].
Conclusion
At week 24, LDA, LLDAS and remission were more stringent than SRI-4 and SRI-6 response, were attainable in the HDA population and discriminated between treatment with atacicept 150 mg and placebo. These results suggest that T2T endpoints are robust outcome measures in SLE clinical trials and support further evaluation of atacicept in SLE.
Trail registration
ClinicalTrials.gov, http://clinicaltrials.gov, NCT01972568
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