Beyond Unprecedented S3 Ep4: Inflation: Not Dead Yet

Over the past 24 months, inflation has soared in the United States, the United Kingdom, and elsewhere. Huw Pill, Chief Economist and Executive Director for Monetary Analysis and research for the Bank of England, discusses the factors driving high inflation and efforts to curb rising prices. (This episode was recorded on April 18, 2023.)https://scholarship.law.columbia.edu/beyond_unprecedented_3/1004/thumbnail.jp

Beyond Unprecedented S3 Ep3: Boardroom Ballot Battles and the Universal Proxy

The U.S. Securities and Exchange Commission recently adopted rules mandating the use of universal proxy cards for electing directors to the boards of public companies. Broadridge Financial Solutions Chief Legal Officer Keir Gumbs discusses the new rules and the potential repercussions of universal proxy card voting for investors and corporations.https://scholarship.law.columbia.edu/beyond_unprecedented_3/1003/thumbnail.jp

Iterative cross-coupling with MIDA boronates

Many small molecules targeted for synthesis in the laboratory are inherently modular in their construction. Harnessing this modularity towards a unified strategy for the synthesis of these compounds, this dissertation describes an approach to small molecule making based on the iterative cross-coupling (ICC) of bifunctional haloboronic acid building blocks. Realizing a general ICC approach in the context of small molecule synthesis required the discovery of a ligand with the capacity to attenuate the reactivity of boronic acids under Suzuki-Miyaura cross-coupling (SMC) conditions and then liberate this masked reactivity under mild conditions. Towards this end, N-methyliminodiacetic acid (MIDA) was discovered to be such a ligand, enabling an approach by which the reactivity of boronic acids is modulated via rehybridization of the boron center. Further, MIDA boronates, which result from the condensation of MIDA with boronic acids, were found to possess a number of enabling properties. Specifically, MIDA boronates are uniformly stable to SiO2 chromatography and to storage under ambient air at room temperature. MIDA boronates were also found to be compatible with a broad range of common reagents and reaction conditions, enabling an approach by which relatively simple MIDA boronates can be elaborated through multiple-step organic synthesis en route to structurally complex boronate building blocks. Through a process of rate-controlled in situ release of boronic acids from the corresponding MIDA boronates, MIDA boronates were found to serve as generally effective surrogates for otherwise unstable boronic acids in high-yielding Suzuki-Miyaura cross-coupling reactions with deactivated aryl chlorides. Enabled by these collective discoveries, and towards the goal of a simple and accessible approach to small molecule synthesis, a machine with the capacity to perform fully automated ICC syntheses was developed and was employed in the syntheses of several natural products

A Supervision of Pliable Presence during a Pandemic

supervision during a pandemic is aided with a flexible presence approach

Beyond Unprecedented S3 Ep2 ESG: Losing Its Cool

The corporate environmental, social, and governance (ESG) movement has come under fire. After many large corporations began to adopt specific ESG measures in response to shareholder pressure, other shareholder groups are trying to undo them. Inclusive Capital Partners co-founders Lynn Forester de Rothschild ’79 and Jeff Ubben discuss the rise in “anti-woke” shareholder activism, the politicization of ESG, and what lies ahead.https://scholarship.law.columbia.edu/beyond_unprecedented_3/1002/thumbnail.jp

The Genetic Age: Who Owns the Genome?: A Symposium on Intellectual Property and the Human Genome, 2 J. Marshall Rev. Intell. Prop. L. 6 (2002)

A Symposium on Intellectual Property Co-Sponsored by The Woodrow Wilson Center. Featuring the remarks of Scott A. Brown, J.D.; Q. Todd Dickinson, J.D.; Stephen P.A. Fodor, Ph.D.; Justin Gillis; Hon. Lee H. Hamilton; Eric S. Lander, Ph.D.; and Pilar Ossorio, Ph.D., J.D

Key Lessons Learned from Moffitt's Molecular Tumor Board: The Clinical Genomics Action Committee Experience

The increasing practicality of genomic sequencing technology has led to its incorporation into routine clinical practice. Successful identification and targeting of driver genomic alterations that provide proliferative and survival advantages to tumor cells have led to approval and ongoing development of several targeted cancer therapies. Within many major cancer centers, molecular tumor boards are constituted to shepherd precision medicine into clinical practice

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts