Introduction to the analysis of delamination related fracture processes in composites

This research concerns the analysis and prediction of delamination damage that occurs in composite structures on the sublaminate scale - that is, the scale of individual plies or groups of plies. The objective was to develop analytical models for fixed-mode delamination in composites. These include: (1) the influence of residual thermal and moisture strains; (2) local or transverse crack tip delamination originating at the tip of transverse matrix cracks; and (3) delamination in tapered composite under tensile loading. Computer codes based on the analytical models were developed and comparisons of predictions with available experimental and analytical results in the literature were performed

Global Assessment Report on Disaster Risk Reduction 2019

The Global Assessment Report on Disaster Risk Reduction (GAR) is the flagship report of the United Nations on worldwide efforts to reduce disaster risk

Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity

Eight novel 2-(2,6-dioxopiperidin-3-yl)phthalimidine EM-12 dithiocarbamates 9 and 10, N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines 11-14 and 3-substituted 2,6-dioxopiperidines 16 and 18 were synthesized as tumor necrosis factor-α (TNF-α) synthesis inhibitors. Synthesis involved utilization of a novel condensation approach, a one-pot reaction involving addition, iminium rearrangement and elimination, to generate the phthalimidine ring required for the creation of compounds 9-14. Agents were, thereafter, quantitatively assessed for their ability to suppress the synthesis on TNF-α in a lipopolysaccharide (LPS)-challenged mouse macrophage-like cellular screen, utilizing cultured RAW 264.7 cells. Whereas compounds 9, 14 and 16 exhibited potent TNF-α lowering activity, reducing TNF-α by up to 48% at 30 μM, compounds 12, 17 and 18 presented moderate TNF-α inhibitory action. The TNF-α lowering properties of these analogs proved more potent than that of revlimid (3) and thalidomide (1). In particular, N-dithiophthalimidomethyl-3-(phthalimidin-2-yl)-2,6-dioxopiperidine 14 not only possessed the greatest potency of the analogs to reduce TNF-α synthesis, but achieved this with minor cellular toxicity at 30 μM. The pharmacological focus of the presented compounds is towards the development of well-tolerated agents to ameliorate the neuroinflammation, that is, commonly associated with neurodegenerative disorders, epitomized by Alzheimer's disease and Parkinson's disease

Transcervical endometrial resection

Study Objectives. To determine the safety and efficacy of endometrial resection, and to provide an indicator of the operative problems and treatment outcomes. Design. Prospective study. Setting. Academic practice tertiary care setting. Patients. One hundred twenty-six consecutive women undergoing endometrial resection because of menorrhagia, who wished to retain their uterus. Intervention. Hysteroscopic endometrial resection performed as a day procedure. Measurements and Main Results. In 126 women, 2 cases of uterine perforation were readily identified on the operating monitor screen; they had no serious sequelae. Three patients had heavy uterine bleeding, which was controlled by intrauterine tamponade. No women had other serious complications. Conclusion. Hysteroscopic endometrial resection is a safe, successful, and cost-effective treatment of menorrhagia