RELIABILITY AND VALIDITY OF THE READINESS FOR INTERPROFESSIONAL LEARNING SCALE (RIPLS) IN TURKISH SPEAKING HEALTH CARE STUDENTS

WOS: 000434980000042Objectives: The purpose of the study was to provide psychometric evaluation of the Turkish version of the Readiness for Interprofessional Learning Scale (RIPLS). Material and methods: This cross-sectional study was carried out with 213 students at the Faculty of Medicine, Faculty of Dentistry and Faculty of Health Sciences. The construct validity of the Turkish version of the scale was analyzed with confirmatory factor analysis (CFA). To determine the reliability of the scale, the Cronbach's alpha coefficient was calculated. In addition, for the assessment of the discrimination of each item on the scale, the top and bottom 27 % from the groups that received the lowest and highest scores from the scale were compared. Results: Standardized coefficients determined with the CFA in the Turkish version of the scale ranged between 0.34 and 0.85 in the students (Except for Item 18). The explained variance values for the items other than item 18 ranged from 0.11 to 0.72. t-values of all the factor loadings were significant. According to the reliability studies of the RIPLS, the internal consistency of Cronbach's Alpha was 0.85 for the overall scale. The t-test results showed that all the items significantly discriminated between students of high and low performance (t: 99.57; p=0.01). Conclusion: As a result, it can be said that the validity and reliability study of the RIPLS administered to Turkish healthcare students indicated that the scale was capable of measuring the Turkish-speaking students' readiness for interprofessional education

Protective role of nebivolol via AKT1/Hif-1?/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model

Methotrexate (MTX) is an antineoplastic and anti-inflammatory agent, which is used in severe diseases. Its use should be limited due to side effects such as nephrotoxicity, myelotoxicity, and hepatotoxicity. Nebivolol (NBV), which is a beta-blocker used in the treatment of hypertension, also contributes to vasodilation in tissues by activating the endothelial nitric oxide synthase (eNOS) enzyme. The purpose of this study is to research the effect of NBV on MTX-induced nephrotoxicity through the AKT1/hypoxia-inducible factor 1-alpha (Hif-1 alpha)/eNOS signaling pathway. The rats were randomly divided into three groups of eight each. The groups were control, MTX, and MTX + NBV. A single dose of 20 mg/kg MTX was given intraperitoneally to the rats on the first day of the study and 10 mg/kg NBV was given orally to the treatment group for 7 days. At the end of the study, rats' blood and kidney tissues were taken for histopathological, immunohistochemical, and biochemical examinations. MTX administration significantly decreased the expression levels of AKT1, eNOS, and Hif-1 alpha compared with the control group (p < 0.001 for all), and NBV treatment increased these values compared with the MTX group (p < 0.001 for all). In conclusion, NBV treatment ameliorated the MTX-induced nephrotoxicity via AKT1/Hif-1 alpha/eNOS signaling pathway

The role of atopy in the pathogenesis of bleomycin pulmonary toxicity.

Introduction: Bleomycin pulmonary toxicity (BPT) is a potentially life-threatening consequence of bleomycin usage in patients. An overproduction of epithelium-derived cytokines, habitually linked to allergic inflammation, has been recently revealed in experimental models of BPT