Saving Lives and Dollars Through Comprehensive Preventive Health Care

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68280/2/10_1111_j_1741-6248_1993_00163_x.pd

A screening, referral, and follow-up program for high blood pressure at Henry Ford Hospital: Part II. Results of referral and follow-up

This is the second of two articles on the Henry Ford Hospital screening, referral, and follow-up program for high blood pressure. The first reported on the screening results of the program, along with associated epidemiological findings. This article presents the results of referral and follow-up. During the period of March 27 through December 11, 1975, 808 people were screened; 196 (24%) were found to have uncontrolled high blood pressure and were referred to physicians for diagnosis and possible treatment for hypertension. The program is currently following up with these people and their physicians to insure successful referral and maintenance of treatment. This paper outlines the overall procedures used for screening, referral, and long-range follow-up. It also presents an evaluation of these procedures, along with outcome data after an average duration often months of follow-up. As of June, 1976, the success rates recorded by the program Include the following: (a) of all people referred for high blood pressure, 86% were successfully referred (had visited a physician for this condition); (b) of the group successfully referred, 90% had entered (or re-entered) treatment for hypertension; and (c) of those under treatment, 67% were showing successful treatment (blood pressure below 140/90) or progressing toward successful treatment (blood pressure below the screening levels of 160/96)

Worksite Follow-Up and Engagement Strategies for Initiating Health Risk Behavior Changes

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66663/2/10.1177_109019819001700409.pd

A family set method for estimating heredity and stress--I : A pilot survey of blood pressure among Negroes in high and low stress areas, Detroit, 1966-1967

A pilot survey designed to test the feasibility of measuring genetic and stress variables as they relate to blood pressure levels was carried out among Negroes residing in high and low stress census tracts in Detroit, 1966-1967. Fifty-six "family sets" or 280 persons were interviewed and blood pressure recordings were taken by trained nurses. Each family set was composed of an index, a spouse, a sibling and a first cousin of index, and an unrelated person in the census tract matched to index. The method and findings of obtaining such family sets is discussed and found to be encouraging enough to initiate a larger study. It was also found that proportions of persons with hypertensive levels were significantly greater in the high stress tract (32 per cent; N = 102) than in the low stress tract (19 per cent; N = 113).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32720/1/0000088.pd

Copper(II) complexes of functionalized 2,2’:6’,2’’-terpyridines and 2,6-di(thiazol-2-yl)pyridine : structure, spectroscopy, cytotoxicity and catalytic activity

Six new copper(II) complexes with 2,2’:6’,2’’-terpyridine (4’-Rn-terpy) [1 (R1 = furan-2-yl), 2 (R2 = thiophen- 2-yl), and 3 (R3 = 1-methyl-1H-pyrrol-2-yl)] and 2,6-di(thiazol-2-yl)pyridine derivatives (Rn-dtpy) [4 (R1), 5 (R2), and 6 (R3)] have been synthesized by a reaction between copper(II) chloride and the corresponding ligand. The complexes have been characterized by UV-vis and IR spectroscopy, and their structures have been determined by X-ray analysis. The antiproliferative potential of copper(II) complexes of 2,2’:6’,2’’-terpyridine and 2,6-di(thiazol-2-yl)pyridine derivatives towards human colorectal (HCT116) and ovarian (A2780) carcinoma as well as towards lung (A549) and breast adenocarcinoma (MCF7) cell lines was examined. Complex 1 and complex 6 were found to have the highest antiproliferative effect on A2780 ovarian carcinoma cells, particularly when compared with complex 2, 3 with no antiproliferative effect. The order of cytotoxicity in this cell line is 6 > 1 > 5 > 4 > 2 ≈ 3. Complex 2 seems to be much more specific towards colorectal carcinoma HCT116 and lung adenocarcinoma A549 cells. The viability loss induced by the complexes agrees with Hoechst 33258 staining and typical morphological apoptotic characteristics like chromatin condensation and nuclear fragmentation. The specificity towards different types of cell lines and the low cytotoxic activity towards healthy cells are of particular interest and are a positive feature for further developments. Complexes 1–6 were also tested in the oxidation of alkanes and alcohols with hydrogen peroxide and tert-butyl-hydroperoxide (TBHP). The most active catalyst 4 gave, after 120 min, 0.105 M of cyclohexanol + cyclohexanone after reduction with PPh3. This concentration corresponds to a yield of 23% and TON = 210. Oxidation of cis-1,2-dimethylcyclohexane with m-CPBA catalyzed by 4 in the presence of HNO3 gave a product of a stereoselective reaction (trans/cis = 0.47). Oxidation of secondary alcohols afforded the target ketones in yields up to 98% and TON = 630

A family set method for estimating heredity and stress--II : Preliminary results of the genetic methodology in a pilot survey of Negro blood pressure, Detroit, 1966-1967

A prior article described in detail a pilot survey designed to measure the effects of heredity and stress on blood pressures among Negroes residing in high and low stress census tracts in Detroit. This report outlines the construction of a genetic variable to analyze the heritable component in blood pressure variability using a family set composed of an index and spouse, a sibling and a first cousin of index, and an unrelated person in the tract matched to index. Given the theoretical proportions describing the degree to which genes are shared between siblings and first cousins, then it follows that variability of a given trait will increase predictably within each family set. Findings from a limited sample of 56 family sets indicate support for a genetic distance scale when measured against variables such as height and skin color; however, the relationship with blood pressure levels is inconclusive. A study now underway will more critically test the tentative findings from this pilot survey.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32721/1/0000089.pd

Deep Learning for Identification of Acute Illness and Facial Cues of Illness

Background: The inclusion of facial and bodily cues (clinical gestalt) in machine learning (ML) models improves the assessment of patients' health status, as shown in genetic syndromes and acute coronary syndrome. It is unknown if the inclusion of clinical gestalt improves ML-based classification of acutely ill patients. As in previous research in ML analysis of medical images, simulated or augmented data may be used to assess the usability of clinical gestalt. Objective: To assess whether a deep learning algorithm trained on a dataset of simulated and augmented facial photographs reflecting acutely ill patients can distinguish between healthy and LPS-infused, acutely ill individuals. Methods: Photographs from twenty-six volunteers whose facial features were manipulated to resemble a state of acute illness were used to extract features of illness and generate a synthetic dataset of acutely ill photographs, using a neural transfer convolutional neural network (NT-CNN) for data augmentation. Then, four distinct CNNs were trained on different parts of the facial photographs and concatenated into one final, stacked CNN which classified individuals as healthy or acutely ill. Finally, the stacked CNN was validated in an external dataset of volunteers injected with lipopolysaccharide (LPS). Results: In the external validation set, the four individual feature models distinguished acutely ill patients with sensitivities ranging from 10.5% (95% CI, 1.3–33.1% for the skin model) to 89.4% (66.9–98.7%, for the nose model). Specificity ranged from 42.1% (20.3–66.5%) for the nose model and 94.7% (73.9–99.9%) for skin. The stacked model combining all four facial features achieved an area under the receiver characteristic operating curve (AUROC) of 0.67 (0.62–0.71) and distinguished acutely ill patients with a sensitivity of 100% (82.35–100.00%) and specificity of 42.11% (20.25–66.50%). Conclusion: A deep learning algorithm trained on a synthetic, augmented dataset of facial photographs distinguished between healthy and simulated acutely ill individuals, demonstrating that synthetically generated data can be used to develop algorithms for health conditions in which large datasets are difficult to obtain. These results support the potential of facial feature analysis algorithms to support the diagnosis of acute illness

Impact of rough substrates on hydrogen doped indium oxides for the application in CIGS devices

Indium oxide based transparent conductive oxides TCOs are promising contact layers in solar cells due totheir outstanding electrical and optical properties. However, when applied in Cu In,Ga Se2or Si hetero junctionsolar cells the specific roughness of the material beneath can affect the growth and the properties of the TCO.We investigated the electrical properties of hydrogen doped and hydrogen tungsten co doped indium oxidesgrown on rough Cu In,Ga Se2samples as well as on textured and planar glass. At sharp ridges and V shapedvalleys crack shaped voids form inside the indium oxide films, which limit the effective electron mobilityof the In2O3 H and In2O3 H,W thin films. This was found for films deposited by magnetron sputtering andreactive plasma deposition at several deposition parameters, before as well as after annealing and solid phasecrystallization. This suggests universal behavior that will have a wide impact on solar cell device