Lipid and Lipoprotein Profiles in Youth With and Without Type 1 Diabetes: The SEARCH for Diabetes in Youth Case-Control Study

OBJECTIVE—The purpose of this study was to compare the lipid profile and the prevalence of lipid abnormalities in youth with and without type 1 diabetes and explore the role of glycemic control on the hypothesized altered lipid profile in youth with type 1 diabetes

Natural inhibitors of coagulation [Dogal koagülasyon inhibitörleri]

Protein C, protein S, and antithrombin III stimulate fibrinolysis by inactivating inhibitors of fibrinolysis, both in vivo and in vitro. In hereditary deficiencies of protein C, protein S and antithrombin III, risk of venous thromboembolic diseases increases significantly. Thrombosis is rarely seen among children. Thrombosis develops in women especially during pregnancy or after oral contraceptive use. In men, an injury or surgical procedure activates thrombosis, later it becomes recurrent and usually it is obstinate. In some patients, despite laboratory proof of persistent low grade hypercoagulability, prolonged asymptomatic intervals are distinctive. As a result this disorder is well known. Thrombotic manifestations become progressively more frequent with increasing age

Acute meningococcaemia complicated by toxic epidermal necrolysis and acute supurative parotitis

WOS: 000227673300016PubMed ID: 15790331

A rare case with myotania congenita [Miyotonia konjenita]

Congenital myotonia is an inherited disorder which is caused by a defect involving proximal portion of short arm of chromosome 19. This disease may present with absence of suckling and respiratory distress. Than weakness of hands, difficulty in walking and frequent fallings may develop. This myotonic disorder was first described by Asmus Julius Thomsen and was defined as a progressive and dominantly inherited disease. However, in 1950, Becker defined recessively inherited congenital myotonia in many families, and reported more prominent findings of myotonia in these families. With this study, by presenting a case with myotonia congenita, we aimed to emphasize to be careful in differential diagnosis of myotonic dystrophy and to prevent patients from invasive procedures like muscle biopsy, which has no role in diagnosis of myotonia congenita

Respiratory distress syndrome [Sikintili solunum sendromu]

Respiratory distress caused by surfactant deficiency and global immaturity of lungs is called "respiratory distress syndrome". Hyaline membrane disease is a pathologic diagnosis characterized by hyaline membrane formation due to alveolar injury and exudation which are caused by surfactant deficiency. All the infants, born before 28 weeks of gestation, and most of the infants, born prior to 32 weeks of gestation, develop RDS

Helicobacter pylori as an etiology of abdominal pain in childhood [Çocukluk çaginda karin agrisi etiyolojisinde Helicobacter pylori]

Helicobacter pylori (HP), that effects half of the population, is known to be the common etiological agent of chronic active gastritis and peptic ulcer disease both in children and adults. Previous studies have shown that the infection is predominantly acquired during childhood. The infection then persist for decades, unless the development of intestinal metaplasia of the gastric mucosa creates a hostile microenvironment for the bacterium. HP presents with abdominal pain on the epigastrium and vomiting. In the diagnosis of recurrent abdominal pain, HP must be taken into consideration

Childhood epilepsies-etiology, diagnosis, treatment, and prognosis [Çocukluk çagi epilepsilerinin etiyoloji, tani, tedavi ve prognozu]

Determination of etiology is important in the management of epilepsies. Todate although there are drugs to reduce the neuranal hiperactivity, non of these drugs can actually prevent epileptic activities. EEG and neuroradiodiagnostics are used in the diagnosis of epileptic foci. In children, seizure type, frequency, pattern, neurologic and mental deficit absence or presence and abnormal wave pattern in EEG are important for prognosis

The classification of epilepsy in childhood [Çocukluk çagi epilepsilerinin siniflandirilmasi]

Epilepsy is an episodic cerebral dysfunction which occurs due to abnormal electrical discharge of neuronal cells of the brain. Epilepsy, having prevalence of 0.5-1%, is the most important chronic disease of pediatric neurology. Epileptic seizure is not a disease, but is a symptom of different factors. Clinic and electrical findings depend on origin and spread of the episode. Classification and definition of epilepsy is difficult, and the term of epilepsy is not sufficient to explain the formation of seizures, clinical spectrum and numerous patterns of the disease. All these difficulties reveal that epilepsy is not an "all or nothing" phenomenon

Hemostasis of the newborn [Yenidoganda hemostaz]

Hemostasis is a series of events that keep bleeding and coagulation equilibrium in normal limits. It is a perfect balance that stops bleeding by vascular spasm and coagulation process, then, by dissolving the resultant clot, restoring damaged vessel to its previous smooth form, providing circulation of blood without clotting in the vessels. Because of the difference of newborn physiology let's review hemostasis of the newborn

Pseudotumor cerebri, after the withdrawal of steroid treatment [Steroid tedavisinin kesimi sonrasi gelişen psödotümör serebri]

Pseudotumor cerebri or benign idiopathic intracranial hypertension is a disease characterized by increased intracranial pressure without any lesion with mass effect or hydrocephaly. In etiology beside several factors, we want to present a case with pseudotumor cerebri after steroid withdrawal because its rarely seen