A Europa e a diáspora evangélica: As pedras angulares do protestantismo como contribuição à casa européia

No artigo é constatado que “há pouca inquietação protestante na Europa” na atualidade. Contextualizando o significado dos conceitos “evangélico” e “protestante” no âmbito da Reforma do século XVI, o autor defende a idéia de uma identidade do protestante de maior inquietação, inconformidade e testemunho do Evangelho em prol do “desenvolvimento social da justiça, paz e liberdade reconciliada”.Esta palestra foi proferida por ocasião do Congresso “Ser protestante na Europa hoje”, ocorrido de 1-3 de setembro de 2004, em Espira. Este congresso foi promovido pelo AGDE em conjunto com a Igreja Evangélica do Palatinado. Título original: Europa und die evangelische Diaspora: Die Ecksteine des Protestantismus als Beitrag zum europäischen Haus. Tradução de Renate Gierus.En el articulo es constatado que “hay poca inquietud protestante em Europa” en la actualidad. Contextualizando el significado de los conceptos “evangélico” y “protestante” en el ámbito de la Reforma del siglo XVI, el autor defiende la idea de una identidad del protestante de mayor inquietud, inconformidad y testimonio del Evangelio en pro del desenvolvimiento social de la justicia, paz y libertad reconciliada.The article points out that “there is little Protestant unrest in Europe” in current times. Contextualizing the meaning of the concepts “Evangelical” and “Protestant” from the perspective of the Reformation in the XVI century, the author defends the idea of a Protestant identity of greater unrest, non-conformity and witness of the Gospel in favor of the “social development of justice, peace and reconciled freedom”

Die Mission der Kirchen in einem säkularisierten Europa

(VLID)97959

Nachweis und Interpretation von Grundwasserschwankungen in einem flussnahen Trinkwasserfördergebiet mittels multivariater Analyse

Hydrogeologie der Nordwestschweiz, Grundwasse

Hemoglobin Kirklareli (α H58L), a New Variant Associated with Iron Deficiency and Increased CO Binding

International audienceMutations in hemoglobin can cause a wide range of pheno-typic outcomes, including anemia due to protein instability and red cell lysis. Uncovering the biochemical basis for these phenotypes can provide new insights into hemoglobin structure and function as well as identify new therapeutic opportunities. We report here a new hemoglobin ␣ chain variant in a female patient with mild anemia, whose father also carries the trait and is from the Turkish city of Kirklareli. Both the patient and her father had a His-58(E7) 3 Leu mutation in ␣1. Surprisingly, the patient's father is not anemic, but he is a smoker with high levels of HbCO (ϳ16%). To understand these phenotypes, we examined recombinant human Hb (rHb) Kirklareli containing the ␣ H58L replacement. Mutant ␣ subunits containing Leu-58(E7) autoxidize ϳ8 times and lose hemin ϳ200 times more rapidly than native ␣ subunits, causing the oxygenated form of rHb Kirklareli to denature very rapidly under physiological conditions. The crystal structure of rHb Kirklareli shows that the ␣ H58L replacement creates a completely apolar active site, which prevents electrostatic stabilization of bound O 2 , promotes autoxidation, and enhances hemin dissociation by inhibiting water coordination to the Fe(III) atom. At the same time, the mutant ␣ subunit has an ϳ80,000-fold higher affinity for CO than O 2 , causing it to rapidly take up and retain carbon monoxide , which prevents denaturation both in vitro and in vivo and explains the phenotypic differences between the father, who is a smoker, and his daughter