Repräsentative SMART-Nachhaltigkeitsbewertung der Bio Suisse-Betriebe. Kurzbericht 2018

Die Knospe gilt als Garant für eine nachhaltige Landwirtschaft. Doch wie nachhaltig wirtschaften die Knospe-Höfe tatsächlich,was läuft gut, wo gibt es Verbesserungspotential? Diesen Fragen gingen das FiBL und die SFS im Auftrag von Bio Suisse auf den Grund. Zum Einsatz kam dabei SMART (Sustainability Monitoring and Assessment RouTine), ein Instrument, welches das FiBL zur ganzheitlichen Nachhaltigkeitsanalyse und Bewertung von landwirtschaftlichen Betrieben und Lebensmittelunternehmen entwickelt hat. Die Bewertung beruht auf einer Betriebsbesichtigung und einem etwa zwei- bis dreistündigen Interview mit den Betriebsleitern zu verschiedenen für die Landwirtschaft relevanten Themenbereichen. Innerhalb von drei Jahren wurden so 185 Höfe auf ihre Nachhaltigkeit hin untersucht. Die Stichprobe wurde so gewählt, dass alle Betriebstypen und Landwirtschaftszonen abgebildet wurden. Zu den Projektzielen gehörten: - Repräsentative Bewertung der Nachhaltigkeitsleistungen der Knospe-Betriebe durch eine externe Institution. - Ermöglichung der kontinuierlichen Entwicklung der Betriebe und Sicherstellung der Zukunftsfähigkeit der Bio Suisse Betriebe sowie der Marke Knospe. - Erarbeitung einer glaubwürdigen Informationsbasis zur Kommunikation der Nachhaltigkeit von Knospe-Betrieben. Die Ergebnisse sollen sowohl für die Verbesserung des Beratungs- und Schulungsangebots im Bereich Nachhaltigkeit als auch für die strategische Weiterentwicklung des Verbands genutzt werden

The potential of retrofitting existing coal power plants: a case study for operation with green iron

Storing electrical energy for long periods and transporting it over long distances is an essential task of the necessary transition to a CO$_2$-free energy economy. An oxidation-reduction cycle based on iron and its oxides represents a very promising technology in this regard. The present work assesses the potential of converting an existing modern coal-fired power plant to operation with iron. For this purpose, a systematic retrofit study is carried out, employing a model that balances all material and energy fluxes in a state-of-the-art coal-fired power plant. Particular attention is given to components of the burner system and the system$'$s heat exchanger. The analysis provides evidence that main components such as the steam generator and steam cycle can be reused with moderate modifications. Major modifications are related to the larger amounts of solids produced during iron combustion, for instance in the particle feeding and removal systems. Since the high particle densities and lower demand for auxiliary systems improve the heat transfer, the net efficiencies of iron operation can be one to two percentage points better than coal operation, depending on operating conditions. This new insight can significantly accelerate the introduction of this innovative technology by guiding future research and the development of the retrofit option.Comment: Applied Energy Journa

Experimental Study of the Influence of Gas Flow Rate on Hydrodynamic Characteristics of Sieve Trays and Their Effect on CO₂ Absorption

An experimental study was conducted in the sieve tray column to investigate the influence of gas flow rate on the hydrodynamic characteristics of the sieve tray, such as total tray pressure drop, wet tray pressure drop, dry tray pressure drop, clear liquid height, liquid holdup, and froth height. The hydrodynamic characteristics of the sieve tray were investigated for the gas/water system at different gas flow rates from 12 to 24 Nm³/h and at different pressures of 0.22, 0.24, and 0.26 MPa. In this study, a simulated waste gas was used that consisted of 30% CO₂ and 70% air. The inlet volumetric flow rate of the water was 0.148 m³/h. The temperature of the inlet water was 19.5°C. The results showed that the gas flow rate has a significant effect on the hydrodynamic characteristics of the tray. The authors investigated the effect of changing these hydrodynamic characteristics on the performance of a tray column used for CO₂ capture

Macromolecule Translocation across the Intestinal Mucosa of HIV-Infected Patients by Transcytosis and through Apoptotic Leaks

Based on indirect evidence, increased mucosal translocation of gut-derived microbial macromolecules has been proposed as an important pathomechanism in HIV infection. Here, we quantified macromolecule translocation across intestinal mucosa from treatment-naive HIV-infected patients, HIV-infected patients treated by combination antiretroviral therapy, and HIV-negative controls and analyzed the translocation pathways involved. Macromolecule permeability was quantified by FITC-Dextran 4000 (FD4) and horseradish peroxidase (HRP) flux measurements. Translocation pathways were addressed using cold inhibition experiments. Tight junction proteins were characterized by immunoblotting. Epithelial apoptosis was quantified and translocation pathways were further characterized by flux studies in T84 cell monolayers using inducers and inhibitors of apoptosis and endocytosis. In duodenal mucosa of untreated but not treated HIV-infected patients, FD4 and HRP permeabilities were more than a 4-fold increase compared to the HIV-negative controls. Duodenal macromolecule permeability was partially temperature-dependent and associated with epithelial apoptosis without altered expression of the analyzed tight junction proteins. In T84 monolayers, apoptosis induction increased, and both apoptosis and endocytosis inhibitors reduced macromolecule permeability. Using quantitative analysis, we demonstrate the increased macromolecule permeability of the intestinal mucosa in untreated HIV-infected patients. Combining structural and mechanistic studies, we identified two pathways of increased macromolecule translocation in HIV infection: transcytosis and passage through apoptotic leaks

Optimization of Integrated Gasification Combined-Cycle Power Plant for Polygeneration of Power and Chemicals

Efficient and flexible operation is essential for competitiveness in the energy market. However, the CO2 emissions of conventional power plants have become an increasingly significant environmental dilemma. In this study, the optimization of a steam power process of an IGCC was carried out, which improved the overall performance of the plant. CCPP with a subcritical HRSG was modelled using EBSILON Professional. The numerical results of the model were validated by measurements for three different load cases (100, 80, and 60%). The results are in agreement with the measured data, with deviations of less than 5% for each case. Based on the model validation, the model was modified for the use of syngas as feed and the integration of heat into an IGCC process. The integration was optimized with respect to the performance of the CCPP by varying the extraction points, adjusting the steam parameters of the extractions and modifying the steam cycle. For the 100% load case, a steam turbine power achieved increase of +34.2%. Finally, the optimized model was subjected to a sensitivity analysis to investigate the effects of varying the extraction mass flows on the output

Representative Farm-Based Sustainability Assessment of the Organic Sector in Switzerland Using the SMART-Farm Tool

The agricultural sector faces serious environmental, social and economic challenges. In response, there has been a proliferation of labels and certifications aiming to ensure minimum farm sustainability performance. Organic agriculture (OA) a prominent example, having received substantial research attention relating to agronomic and environmental performance. While international OA movements are evolving to include broader sustainability aspirations, limited research exists on the social and economic performance of OA. To address this, we conducted a representative farm-based assessment of the Swiss organic sector to evaluate its contribution to sustainability across a wide range of themes based on the FAO Sustainability of Agriculture and Food Assessment (SAFA) Guidelines. We assessed 185 farms using the Sustainability Assessment and Monitoring RouTine (SMART) Farm Tool, chosen through stratified random sampling by farm type and agricultural zone. The results indicate that the Swiss organic sector makes a substantially positive contribution to sustainability, with average scores for theme goal achievement of 62% (Good Governance), 77% (Environmental Integrity), 70% (Economic Resilience), and 87% (Social Well-being). A set of 45 influential indicators (28 for plant production/mix farms and 30 for livestock farms) were selected based on the ability to explain variance (using Principal Component Analysis) and importance for goal achievement. The indicator sets explained a large amount of variation (ca. 70% for both farm types) and revealed a snapshot of management topics relevant to sustainability performance across the sector. These covered socio-political engagement, emissions to air and water, biodiversity, animal welfare, profitability, vulnerability, product quality, local economy, capacity building, and workplace risks. The spread of results across the sample, and comparisons to secondary data (literature and official statistics), revealed the importance of both well-studied issues (e.g., wide spread of energy consumption, variable yield levels/stability, local value chain dynamics) and more novel insights (e.g., strong political engagement, variable price premiums, lacking social security of farming families, insecure land tenure). We propose these topics as a basis for deeper analysis, designing improvement measures and conducting comparative research. This would bring much-needed breadth into the typically narrow debate surrounding the relative merits of OA

PuraStat in gastrointestinal bleeding: results of a prospective multicentre observational pilot study

Background: A recently developed haemostatic peptide gel for endoscopic application has been introduced to improve the management of gastrointestinal bleeding. The aim of this pilot study was to evaluate the feasibility, safety, efficacy and indication profiles of PuraStat in a clinical setting. Methods: In this prospective observational multicentre pilot study, patients with acute non-variceal gastrointestinal bleeding (upper and lower) were included. Primary and secondary application of PuraStat was evaluated. Haemoglobin, prothrombin time, platelets and transfusion behaviour were documented before and after haemostasis. The efficacy of PuraStat was assessed during the procedure, at 3 days and 1 week after application. Results: 111 patients with acute gastrointestinal bleeding were recruited into the study. 70 percent (78/111) of the patients had upper gastrointestinal bleeding and 30% (33/111) had lower gastrointestinal bleeding. After primary application of PuraStat, initial haemostatic success was achieved in 94% of patients (74/79, 95% CI 88-99%), and in 75% of the patients when used as a secondary haemostatic product, following failure of established techniques (24/32, 95% CI 59-91%). The therapeutic success rates (absence of rebleeding) after 3 and 7 days were 91% and 87% after primary use, and 87% and 81% in all study patients. Overall rebleeding rate at 30 day follow-up was 16% (18/111). In the 5 patients who finally required surgery (4.5%), PuraStat allowed temporary haemostasis and stabilisation. Conclusions: PuraStat expanded the therapeutic toolbox available for an effective treatment of gastrointestinal bleeding sources. It could be safely applied and administered without complications as a primary or secondary therapy. PuraStat may additionally serve as a bridge to surgery in order to achieve temporary haemostasis in case of refractory severe bleeding, possibly playing a role in preventing immediate emergency surgery

Memory CD8+ T Cells Balance Pro- and Anti-inflammatory Activity by Reprogramming Cellular Acetate Handling at Sites of Infection.

Serum acetate increases upon systemic infection. Acutely, assimilation of acetate expands the capacity of memory CD8+ T cells to produce IFN-γ. Whether acetate modulates memory CD8+ T cell metabolism and function during pathogen re-encounter remains unexplored. Here we show that at sites of infection, high acetate concentrations are being reached, yet memory CD8+ T cells shut down the acetate assimilating enzymes ACSS1 and ACSS2. Acetate, being thus largely excluded from incorporation into cellular metabolic pathways, now had different effects, namely (1) directly activating glutaminase, thereby augmenting glutaminolysis, cellular respiration, and survival, and (2) suppressing TCR-triggered calcium flux, and consequently cell activation and effector cell function. In vivo, high acetate abundance at sites of infection improved pathogen clearance while reducing immunopathology. This indicates that, during different stages of the immune response, the same metabolite-acetate-induces distinct immunometabolic programs within the same cell type

A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments

PVP-capped silver nanoparticles with a diameter of the metallic core of 70 nm, a hydrodynamic diameter of 120 nm and a zeta potential of −20 mV were prepared and investigated with regard to their biological activity. This review summarizes the physicochemical properties (dissolution, protein adsorption, dispersability) of these nanoparticles and the cellular consequences of the exposure of a broad range of biological test systems to this defined type of silver nanoparticles. Silver nanoparticles dissolve in water in the presence of oxygen. In addition, in biological media (i.e., in the presence of proteins) the surface of silver nanoparticles is rapidly coated by a protein corona that influences their physicochemical and biological properties including cellular uptake. Silver nanoparticles are taken up by cell-type specific endocytosis pathways as demonstrated for hMSC, primary T-cells, primary monocytes, and astrocytes. A visualization of particles inside cells is possible by X-ray microscopy, fluorescence microscopy, and combined FIB/SEM analysis. By staining organelles, their localization inside the cell can be additionally determined. While primary brain astrocytes are shown to be fairly tolerant toward silver nanoparticles, silver nanoparticles induce the formation of DNA double-strand-breaks (DSB) and lead to chromosomal aberrations and sister-chromatid exchanges in Chinese hamster fibroblast cell lines (CHO9, K1, V79B). An exposure of rats to silver nanoparticles in vivo induced a moderate pulmonary toxicity, however, only at rather high concentrations. The same was found in precision-cut lung slices of rats in which silver nanoparticles remained mainly at the tissue surface. In a human 3D triple-cell culture model consisting of three cell types (alveolar epithelial cells, macrophages, and dendritic cells), adverse effects were also only found at high silver concentrations. The silver ions that are released from silver nanoparticles may be harmful to skin with disrupted barrier (e.g., wounds) and induce oxidative stress in skin cells (HaCaT). In conclusion, the data obtained on the effects of this well-defined type of silver nanoparticles on various biological systems clearly demonstrate that cell-type specific properties as well as experimental conditions determine the biocompatibility of and the cellular responses to an exposure with silver nanoparticles